Matrix Metalloproteinases in Health and Disease
Matrix metalloproteinases (MMPs) are members of an enzyme family and are critical for maintaining tissue allostasis. MMPs can catalyze normal turnover of the extracellular matrix (ECM) together with other metalloproteinases such as ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin...
שמור ב:
| פורמט: | Online |
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| שפה: | אנגלית |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| נושאים: | |
| גישה מקוונת: | ONIX_20210501_9783039430529_808 |
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| _version_ | 1869524009343778816 |
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| collection | Directory of Open Access Books |
| description | Matrix metalloproteinases (MMPs) are members of an enzyme family and are critical for maintaining tissue allostasis. MMPs can catalyze normal turnover of the extracellular matrix (ECM) together with other metalloproteinases such as ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) families. MMP activity is also regulated by a group of endogenous proteins called tissue inhibitor of metalloproteinases (TIMPs). All these proteins have a pivotal role involving ECM remodelling in normal physiological processes such as wound healing, embryogenesis, angiogenesis, bone remodelling, immunity, and the female reproductive cycle. An imbalance in the expression or activity of MMPs can also have important consequences in diseases such as cancer, cardiovascular disease, peripheral vascular disease, chronic leg ulcers, and multiple sclerosis. In recent years, MMPs have been found to play an important role in the field of precision medicine, as they may serve as biomarkers that may predict an individual’s disease predisposition, state, or progression. MMPs are also thought to be a sensible target for molecular therapy. The aim of this Special Issue is to explore the most recent findings in this field that may have an impact in healthcare systems. |
| format | Online |
| id | doab-20.500.12854ir-69062 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-690622024-04-01T23:19:24Z Matrix Metalloproteinases in Health and Disease Serra, Raffaele hypersensitivity pneumonitis metalloproteinases genetic association autoantibodies MMP1 MMP2 SNPs MMPs TIMPs CKD peripheral vascular disease biomarkers proteinuria eGFR PAD. NGAL statins arterial aneurysms patients collagenases Crohn’s disease dental caries mouth periodontitis matrix metalloproteinase-9 dialysis on-line hemodiafiltration high-flux dialysis renal replacement therapy kidney transplantation Mac-1 CD147 leukocytes platelets adhesion integrin αMβ2 matrix metalloproteinases TIMP synthetic inhibitors RECK matrix metalloproteinase MAPKs ischemia/reperfusion eNOS iNOS inflammatory bowel disease inflammation NO MMP-9 cGMP Caco-2 matrix metalloproteinase-7 fibrosis acute kidney injury chronic kidney disease apoptosis health disease thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues Matrix metalloproteinases (MMPs) are members of an enzyme family and are critical for maintaining tissue allostasis. MMPs can catalyze normal turnover of the extracellular matrix (ECM) together with other metalloproteinases such as ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) families. MMP activity is also regulated by a group of endogenous proteins called tissue inhibitor of metalloproteinases (TIMPs). All these proteins have a pivotal role involving ECM remodelling in normal physiological processes such as wound healing, embryogenesis, angiogenesis, bone remodelling, immunity, and the female reproductive cycle. An imbalance in the expression or activity of MMPs can also have important consequences in diseases such as cancer, cardiovascular disease, peripheral vascular disease, chronic leg ulcers, and multiple sclerosis. In recent years, MMPs have been found to play an important role in the field of precision medicine, as they may serve as biomarkers that may predict an individual’s disease predisposition, state, or progression. MMPs are also thought to be a sensible target for molecular therapy. The aim of this Special Issue is to explore the most recent findings in this field that may have an impact in healthcare systems. 2021-05-01T15:40:16Z 2021-05-01T15:40:16Z 2020 book ONIX_20210501_9783039430529_808 9783039430529 9783039430536 https://directory.doabooks.org/handle/20.500.12854/69062 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2831 https://mdpi.com/books/pdfview/book/2831 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03943-053-6 10.3390/books978-3-03943-053-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039430529 9783039430536 196 Basel, Switzerland open access |
| spellingShingle | hypersensitivity pneumonitis metalloproteinases genetic association autoantibodies MMP1 MMP2 SNPs MMPs TIMPs CKD peripheral vascular disease biomarkers proteinuria eGFR PAD. NGAL statins arterial aneurysms patients collagenases Crohn’s disease dental caries mouth periodontitis matrix metalloproteinase-9 dialysis on-line hemodiafiltration high-flux dialysis renal replacement therapy kidney transplantation Mac-1 CD147 leukocytes platelets adhesion integrin αMβ2 matrix metalloproteinases TIMP synthetic inhibitors RECK matrix metalloproteinase MAPKs ischemia/reperfusion eNOS iNOS inflammatory bowel disease inflammation NO MMP-9 cGMP Caco-2 matrix metalloproteinase-7 fibrosis acute kidney injury chronic kidney disease apoptosis health disease thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues Matrix Metalloproteinases in Health and Disease |
| title | Matrix Metalloproteinases in Health and Disease |
| title_full | Matrix Metalloproteinases in Health and Disease |
| title_fullStr | Matrix Metalloproteinases in Health and Disease |
| title_full_unstemmed | Matrix Metalloproteinases in Health and Disease |
| title_short | Matrix Metalloproteinases in Health and Disease |
| title_sort | matrix metalloproteinases in health and disease |
| topic | hypersensitivity pneumonitis metalloproteinases genetic association autoantibodies MMP1 MMP2 SNPs MMPs TIMPs CKD peripheral vascular disease biomarkers proteinuria eGFR PAD. NGAL statins arterial aneurysms patients collagenases Crohn’s disease dental caries mouth periodontitis matrix metalloproteinase-9 dialysis on-line hemodiafiltration high-flux dialysis renal replacement therapy kidney transplantation Mac-1 CD147 leukocytes platelets adhesion integrin αMβ2 matrix metalloproteinases TIMP synthetic inhibitors RECK matrix metalloproteinase MAPKs ischemia/reperfusion eNOS iNOS inflammatory bowel disease inflammation NO MMP-9 cGMP Caco-2 matrix metalloproteinase-7 fibrosis acute kidney injury chronic kidney disease apoptosis health disease thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues |
| topic_facet | hypersensitivity pneumonitis metalloproteinases genetic association autoantibodies MMP1 MMP2 SNPs MMPs TIMPs CKD peripheral vascular disease biomarkers proteinuria eGFR PAD. NGAL statins arterial aneurysms patients collagenases Crohn’s disease dental caries mouth periodontitis matrix metalloproteinase-9 dialysis on-line hemodiafiltration high-flux dialysis renal replacement therapy kidney transplantation Mac-1 CD147 leukocytes platelets adhesion integrin αMβ2 matrix metalloproteinases TIMP synthetic inhibitors RECK matrix metalloproteinase MAPKs ischemia/reperfusion eNOS iNOS inflammatory bowel disease inflammation NO MMP-9 cGMP Caco-2 matrix metalloproteinase-7 fibrosis acute kidney injury chronic kidney disease apoptosis health disease thema EDItEUR::N History and Archaeology::NH History thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues |
| url | ONIX_20210501_9783039430529_808 |