Stem Cell Research on Cardiology
Even today, cardiovascular diseases are the main cause of death worldwide, and therapeutic approaches are very restricted. Due to the limited regenerative capabilities of terminally differentiated cardiomyocytes post injury, new strategies to treat cardiac patients are urgently needed. Post myocardi...
Збережено в:
| Формат: | Online |
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| Мова: | Англійська |
| Опубліковано: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Предмети: | |
| Онлайн доступ: | ONIX_20210501_9783039431922_898 |
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| _version_ | 1869521095293403136 |
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| collection | Directory of Open Access Books |
| description | Even today, cardiovascular diseases are the main cause of death worldwide, and therapeutic approaches are very restricted. Due to the limited regenerative capabilities of terminally differentiated cardiomyocytes post injury, new strategies to treat cardiac patients are urgently needed. Post myocardial injury, resident fibroblasts begin to generate the extracellular matrix, resulting in fibrosis, and finally, cardiac failure. Recently, preclinical investigations and clinical trials raised hope in stem cell-based approaches, to be an effective therapy option for these diseases. So far, several types of stem cells have been identified to be promising candidates to be applied for treatment: cardiac progenitor cells, bone marrow derived stem cells, embryonic and induced pluripotent stem cells, as well as their descendants. Furthermore, the innovative techniques of direct cardiac reprogramming of cells offered promising options for cardiovascular research, in vitro and in vivo. Hereby, the investigation of underlying and associated mechanisms triggering the therapeutic effects of stem cell application is of particular importance to improve approaches for heart patients. This Special Issue of Cells provides the latest update in the rapidly developing field of regenerative medicine in cardiology. |
| format | Online |
| id | doab-20.500.12854ir-69152 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-691522024-03-28T03:33:32Z Stem Cell Research on Cardiology David, Robert Fabry disease human embryonic stem cells CRISPR/Cas9 genomic editing Mass spectrometry proteomic analysis hypertrophic cardiomyopathy disease model physical exercise cardiac cellular regeneration microRNA (miR) Akt signaling cardiomyocyte proliferation cardiac hypertrophy cardioprotection myocarditis inflammation leukocytes cardiomyocytes multi-electrode-array micro-electrode-array MEA drug/toxicity screening field potential arrhythmia electrocardiography cardiac regeneration stem cells iPSC PSC ESC cardiovascular disease regeneration cardiac progenitor cells induced pluripotent stem cells transdifferentiation direct reprogramming genetic engineering cardiac tissue engineering biomaterials 18F-FDG PET cardiac induced cells cardiac function non-invasive imaging human pluripotent stem cell ventricular maturation bone marrow stem cells angiogenesis myocardial infarction human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) iPS cells big conductance calcium activated potassium channel (BK) Maxi-K slo1 KCa1.1 iberiotoxin long QT syndrome mesenchymal stromal cells (MSC) mRNA miRNA cardiac reprogramming cardiac differentiation cardiovascular diseases adult stem cells myocardial infraction 3D printing 3D model bioprinting cardiovascular medicine heart myocardium heart valves vascular graft endothelialization tissue engineering decorin fibronectin electrospinning endothelial progenitor cells bioreactor biostable polyurethane MicroRNA Mir-133 coronary heart disease biomarker meta-analysis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Even today, cardiovascular diseases are the main cause of death worldwide, and therapeutic approaches are very restricted. Due to the limited regenerative capabilities of terminally differentiated cardiomyocytes post injury, new strategies to treat cardiac patients are urgently needed. Post myocardial injury, resident fibroblasts begin to generate the extracellular matrix, resulting in fibrosis, and finally, cardiac failure. Recently, preclinical investigations and clinical trials raised hope in stem cell-based approaches, to be an effective therapy option for these diseases. So far, several types of stem cells have been identified to be promising candidates to be applied for treatment: cardiac progenitor cells, bone marrow derived stem cells, embryonic and induced pluripotent stem cells, as well as their descendants. Furthermore, the innovative techniques of direct cardiac reprogramming of cells offered promising options for cardiovascular research, in vitro and in vivo. Hereby, the investigation of underlying and associated mechanisms triggering the therapeutic effects of stem cell application is of particular importance to improve approaches for heart patients. This Special Issue of Cells provides the latest update in the rapidly developing field of regenerative medicine in cardiology. 2021-05-01T15:42:17Z 2021-05-01T15:42:17Z 2020 book ONIX_20210501_9783039431922_898 9783039431922 9783039431939 https://directory.doabooks.org/handle/20.500.12854/69152 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2924 https://mdpi.com/books/pdfview/book/2924 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03943-193-9 10.3390/books978-3-03943-193-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039431922 9783039431939 356 Basel, Switzerland open access |
| spellingShingle | Fabry disease human embryonic stem cells CRISPR/Cas9 genomic editing Mass spectrometry proteomic analysis hypertrophic cardiomyopathy disease model physical exercise cardiac cellular regeneration microRNA (miR) Akt signaling cardiomyocyte proliferation cardiac hypertrophy cardioprotection myocarditis inflammation leukocytes cardiomyocytes multi-electrode-array micro-electrode-array MEA drug/toxicity screening field potential arrhythmia electrocardiography cardiac regeneration stem cells iPSC PSC ESC cardiovascular disease regeneration cardiac progenitor cells induced pluripotent stem cells transdifferentiation direct reprogramming genetic engineering cardiac tissue engineering biomaterials 18F-FDG PET cardiac induced cells cardiac function non-invasive imaging human pluripotent stem cell ventricular maturation bone marrow stem cells angiogenesis myocardial infarction human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) iPS cells big conductance calcium activated potassium channel (BK) Maxi-K slo1 KCa1.1 iberiotoxin long QT syndrome mesenchymal stromal cells (MSC) mRNA miRNA cardiac reprogramming cardiac differentiation cardiovascular diseases adult stem cells myocardial infraction 3D printing 3D model bioprinting cardiovascular medicine heart myocardium heart valves vascular graft endothelialization tissue engineering decorin fibronectin electrospinning endothelial progenitor cells bioreactor biostable polyurethane MicroRNA Mir-133 coronary heart disease biomarker meta-analysis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Stem Cell Research on Cardiology |
| title | Stem Cell Research on Cardiology |
| title_full | Stem Cell Research on Cardiology |
| title_fullStr | Stem Cell Research on Cardiology |
| title_full_unstemmed | Stem Cell Research on Cardiology |
| title_short | Stem Cell Research on Cardiology |
| title_sort | stem cell research on cardiology |
| topic | Fabry disease human embryonic stem cells CRISPR/Cas9 genomic editing Mass spectrometry proteomic analysis hypertrophic cardiomyopathy disease model physical exercise cardiac cellular regeneration microRNA (miR) Akt signaling cardiomyocyte proliferation cardiac hypertrophy cardioprotection myocarditis inflammation leukocytes cardiomyocytes multi-electrode-array micro-electrode-array MEA drug/toxicity screening field potential arrhythmia electrocardiography cardiac regeneration stem cells iPSC PSC ESC cardiovascular disease regeneration cardiac progenitor cells induced pluripotent stem cells transdifferentiation direct reprogramming genetic engineering cardiac tissue engineering biomaterials 18F-FDG PET cardiac induced cells cardiac function non-invasive imaging human pluripotent stem cell ventricular maturation bone marrow stem cells angiogenesis myocardial infarction human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) iPS cells big conductance calcium activated potassium channel (BK) Maxi-K slo1 KCa1.1 iberiotoxin long QT syndrome mesenchymal stromal cells (MSC) mRNA miRNA cardiac reprogramming cardiac differentiation cardiovascular diseases adult stem cells myocardial infraction 3D printing 3D model bioprinting cardiovascular medicine heart myocardium heart valves vascular graft endothelialization tissue engineering decorin fibronectin electrospinning endothelial progenitor cells bioreactor biostable polyurethane MicroRNA Mir-133 coronary heart disease biomarker meta-analysis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | Fabry disease human embryonic stem cells CRISPR/Cas9 genomic editing Mass spectrometry proteomic analysis hypertrophic cardiomyopathy disease model physical exercise cardiac cellular regeneration microRNA (miR) Akt signaling cardiomyocyte proliferation cardiac hypertrophy cardioprotection myocarditis inflammation leukocytes cardiomyocytes multi-electrode-array micro-electrode-array MEA drug/toxicity screening field potential arrhythmia electrocardiography cardiac regeneration stem cells iPSC PSC ESC cardiovascular disease regeneration cardiac progenitor cells induced pluripotent stem cells transdifferentiation direct reprogramming genetic engineering cardiac tissue engineering biomaterials 18F-FDG PET cardiac induced cells cardiac function non-invasive imaging human pluripotent stem cell ventricular maturation bone marrow stem cells angiogenesis myocardial infarction human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) iPS cells big conductance calcium activated potassium channel (BK) Maxi-K slo1 KCa1.1 iberiotoxin long QT syndrome mesenchymal stromal cells (MSC) mRNA miRNA cardiac reprogramming cardiac differentiation cardiovascular diseases adult stem cells myocardial infraction 3D printing 3D model bioprinting cardiovascular medicine heart myocardium heart valves vascular graft endothelialization tissue engineering decorin fibronectin electrospinning endothelial progenitor cells bioreactor biostable polyurethane MicroRNA Mir-133 coronary heart disease biomarker meta-analysis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20210501_9783039431922_898 |