Botulinum Toxin Treatment for Pain and Inflammation in Functional Urological Disorders
The botulinum toxin has been widely applied in the treatment of functional urological diseases, such as overactive bladder, neurogenic detrusor overactivity, interstitial cystitis, and chronic pelvic pain syndrome. Evidence has shown that the botulinum toxin not only affects the release of neuropept...
Պահպանված է:
| Ձևաչափ: | Online |
|---|---|
| Լեզու: | անգլերեն |
| Հրապարակվել է: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
|
| Խորագրեր: | |
| Առցանց հասանելիություն: | ONIX_20210501_9783039366705_909 |
| Ցուցիչներ: |
Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
|
| _version_ | 1869528322145255424 |
|---|---|
| collection | Directory of Open Access Books |
| description | The botulinum toxin has been widely applied in the treatment of functional urological diseases, such as overactive bladder, neurogenic detrusor overactivity, interstitial cystitis, and chronic pelvic pain syndrome. Evidence has shown that the botulinum toxin not only affects the release of neuropeptides from motor nerve endings, but also connects sensory nerves to the central nervous system. Inflammation in the central nervous system can be reduced after botulinum toxin treatment. The scope of therapeutic targets involves detrusor overactivity, sensory disorders, bladder pain and pelvic pain, and inflammatory disorders of the bladder, prostate, and bladder outlet. Although the actual pathophysiological mechanism of the action of the botulinum toxin has not been completely demonstrated, an anti-inflammation effect might be the predominant therapeutic mechanism for functional urological disorders such as an overactive bladder, bladder hypersensitivity, interstitial cystitis, chronic pelvic pain syndrome, chronic prostatitis, and lower urinary tract symptoms/benign prostatic hyperplasia. This Special Issue of Toxins covers the therapeutic potentials of the botulinum toxin on lower urinary tract dysfunctions, with emphasis on the mechanism of pharmacological action and clinical effects. |
| format | Online |
| id | doab-20.500.12854ir-69163 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-691632024-03-31T13:09:58Z Botulinum Toxin Treatment for Pain and Inflammation in Functional Urological Disorders Kuo, Hann-Chorng urethra onabotulinumtoxinA voiding therapeutic outcome lower urinary tract symptoms botulinum toxin benign prostatic hyperplasia prostatitis inflammation Botulinum toxin chronic prostatitis interstitial cystitis treatment bladder pain botulinum toxin A predictor maximal bladder capacity hydrodistention urethral sphincter urethral sphincter dysfunction urodynamics drug delivery overactive bladder painful bladder syndrome molecular mechanism chronic pelvic pain syndrome pelvic pain functional urology disorder human network meta-analysis OnabotulinumtoxinA peripheral tibial nerve stimulation sacral neuromodulation bladder sensation therapy pathophysiology diabetes mellitus mid-urethral sling antimuscarinics urinary incontinence functional urological disorders pain neurogenic detrusor overactivity thema EDItEUR::M Medicine and Nursing The botulinum toxin has been widely applied in the treatment of functional urological diseases, such as overactive bladder, neurogenic detrusor overactivity, interstitial cystitis, and chronic pelvic pain syndrome. Evidence has shown that the botulinum toxin not only affects the release of neuropeptides from motor nerve endings, but also connects sensory nerves to the central nervous system. Inflammation in the central nervous system can be reduced after botulinum toxin treatment. The scope of therapeutic targets involves detrusor overactivity, sensory disorders, bladder pain and pelvic pain, and inflammatory disorders of the bladder, prostate, and bladder outlet. Although the actual pathophysiological mechanism of the action of the botulinum toxin has not been completely demonstrated, an anti-inflammation effect might be the predominant therapeutic mechanism for functional urological disorders such as an overactive bladder, bladder hypersensitivity, interstitial cystitis, chronic pelvic pain syndrome, chronic prostatitis, and lower urinary tract symptoms/benign prostatic hyperplasia. This Special Issue of Toxins covers the therapeutic potentials of the botulinum toxin on lower urinary tract dysfunctions, with emphasis on the mechanism of pharmacological action and clinical effects. 2021-05-01T15:42:46Z 2021-05-01T15:42:46Z 2020 book ONIX_20210501_9783039366705_909 9783039366705 9783039366712 https://directory.doabooks.org/handle/20.500.12854/69163 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2935 https://mdpi.com/books/pdfview/book/2935 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03936-671-2 10.3390/books978-3-03936-671-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039366705 9783039366712 196 Basel, Switzerland open access |
| spellingShingle | urethra onabotulinumtoxinA voiding therapeutic outcome lower urinary tract symptoms botulinum toxin benign prostatic hyperplasia prostatitis inflammation Botulinum toxin chronic prostatitis interstitial cystitis treatment bladder pain botulinum toxin A predictor maximal bladder capacity hydrodistention urethral sphincter urethral sphincter dysfunction urodynamics drug delivery overactive bladder painful bladder syndrome molecular mechanism chronic pelvic pain syndrome pelvic pain functional urology disorder human network meta-analysis OnabotulinumtoxinA peripheral tibial nerve stimulation sacral neuromodulation bladder sensation therapy pathophysiology diabetes mellitus mid-urethral sling antimuscarinics urinary incontinence functional urological disorders pain neurogenic detrusor overactivity thema EDItEUR::M Medicine and Nursing Botulinum Toxin Treatment for Pain and Inflammation in Functional Urological Disorders |
| title | Botulinum Toxin Treatment for Pain and Inflammation in Functional Urological Disorders |
| title_full | Botulinum Toxin Treatment for Pain and Inflammation in Functional Urological Disorders |
| title_fullStr | Botulinum Toxin Treatment for Pain and Inflammation in Functional Urological Disorders |
| title_full_unstemmed | Botulinum Toxin Treatment for Pain and Inflammation in Functional Urological Disorders |
| title_short | Botulinum Toxin Treatment for Pain and Inflammation in Functional Urological Disorders |
| title_sort | botulinum toxin treatment for pain and inflammation in functional urological disorders |
| topic | urethra onabotulinumtoxinA voiding therapeutic outcome lower urinary tract symptoms botulinum toxin benign prostatic hyperplasia prostatitis inflammation Botulinum toxin chronic prostatitis interstitial cystitis treatment bladder pain botulinum toxin A predictor maximal bladder capacity hydrodistention urethral sphincter urethral sphincter dysfunction urodynamics drug delivery overactive bladder painful bladder syndrome molecular mechanism chronic pelvic pain syndrome pelvic pain functional urology disorder human network meta-analysis OnabotulinumtoxinA peripheral tibial nerve stimulation sacral neuromodulation bladder sensation therapy pathophysiology diabetes mellitus mid-urethral sling antimuscarinics urinary incontinence functional urological disorders pain neurogenic detrusor overactivity thema EDItEUR::M Medicine and Nursing |
| topic_facet | urethra onabotulinumtoxinA voiding therapeutic outcome lower urinary tract symptoms botulinum toxin benign prostatic hyperplasia prostatitis inflammation Botulinum toxin chronic prostatitis interstitial cystitis treatment bladder pain botulinum toxin A predictor maximal bladder capacity hydrodistention urethral sphincter urethral sphincter dysfunction urodynamics drug delivery overactive bladder painful bladder syndrome molecular mechanism chronic pelvic pain syndrome pelvic pain functional urology disorder human network meta-analysis OnabotulinumtoxinA peripheral tibial nerve stimulation sacral neuromodulation bladder sensation therapy pathophysiology diabetes mellitus mid-urethral sling antimuscarinics urinary incontinence functional urological disorders pain neurogenic detrusor overactivity thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039366705_909 |