Hedgehog Signaling in Organogenesis and Tumor Microenvironment
The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning. Several recent studies have shown that the aberrant activation of Hedgehog signaling is associated with...
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| Format: | Online |
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| Jezik: | engleski |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Teme: | |
| Online pristup: | ONIX_20210501_9783039362608_913 |
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| _version_ | 1869522018840346624 |
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| collection | Directory of Open Access Books |
| description | The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning. Several recent studies have shown that the aberrant activation of Hedgehog signaling is associated with neoplastic transformation, cancer cell proliferation, metastasis, multiple cancers’ drug resistance, and survival rates. This book focuses on several aspects of Hedgehog signaling in organogenesis and the tumor microenvironment, and presents reviews and original papers on recent efforts in the field of Hedgehog signaling. |
| format | Online |
| id | doab-20.500.12854ir-69167 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-691672024-03-30T23:22:57Z Hedgehog Signaling in Organogenesis and Tumor Microenvironment Shimo, Tsuyoshi Cyp26 enzymes congenital anomalies CRE/LoxP hedgehog signaling mouse models retinoic acid smoothened sonic hedgehog sonic hedgehog (SHH) oral squamous cell carcinoma (OSCC) tumor microenvironment (TME) tumor-associated macrophages (TAMs) cancer-associated fibroblasts (CAFs) tumor-associated angiogenesis hedgehog growth plate endochondral ossification chondrocyte osteoblast bone disease TMJ synovial joint articular disc Ihh PTHrP osteoarthritis epithelial–mesenchymal interaction (EMI) prostate cancer external genitalia androgen basement membrane bone morphogenetic protein stem cell animal experiment fracture healing cancer stem cells hypospadias urethra penis bone hedgehog signalling tooth development epithelial and mesenchymal interaction Gli1 mesenchymal stem cell lineage tracing analysis stem cell marker n/a thema EDItEUR::M Medicine and Nursing The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning. Several recent studies have shown that the aberrant activation of Hedgehog signaling is associated with neoplastic transformation, cancer cell proliferation, metastasis, multiple cancers’ drug resistance, and survival rates. This book focuses on several aspects of Hedgehog signaling in organogenesis and the tumor microenvironment, and presents reviews and original papers on recent efforts in the field of Hedgehog signaling. 2021-05-01T15:42:52Z 2021-05-01T15:42:52Z 2020 book ONIX_20210501_9783039362608_913 9783039362608 9783039362615 https://directory.doabooks.org/handle/20.500.12854/69167 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2939 https://mdpi.com/books/pdfview/book/2939 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03936-261-5 10.3390/books978-3-03936-261-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039362608 9783039362615 172 Basel, Switzerland open access |
| spellingShingle | Cyp26 enzymes congenital anomalies CRE/LoxP hedgehog signaling mouse models retinoic acid smoothened sonic hedgehog sonic hedgehog (SHH) oral squamous cell carcinoma (OSCC) tumor microenvironment (TME) tumor-associated macrophages (TAMs) cancer-associated fibroblasts (CAFs) tumor-associated angiogenesis hedgehog growth plate endochondral ossification chondrocyte osteoblast bone disease TMJ synovial joint articular disc Ihh PTHrP osteoarthritis epithelial–mesenchymal interaction (EMI) prostate cancer external genitalia androgen basement membrane bone morphogenetic protein stem cell animal experiment fracture healing cancer stem cells hypospadias urethra penis bone hedgehog signalling tooth development epithelial and mesenchymal interaction Gli1 mesenchymal stem cell lineage tracing analysis stem cell marker n/a thema EDItEUR::M Medicine and Nursing Hedgehog Signaling in Organogenesis and Tumor Microenvironment |
| title | Hedgehog Signaling in Organogenesis and Tumor Microenvironment |
| title_full | Hedgehog Signaling in Organogenesis and Tumor Microenvironment |
| title_fullStr | Hedgehog Signaling in Organogenesis and Tumor Microenvironment |
| title_full_unstemmed | Hedgehog Signaling in Organogenesis and Tumor Microenvironment |
| title_short | Hedgehog Signaling in Organogenesis and Tumor Microenvironment |
| title_sort | hedgehog signaling in organogenesis and tumor microenvironment |
| topic | Cyp26 enzymes congenital anomalies CRE/LoxP hedgehog signaling mouse models retinoic acid smoothened sonic hedgehog sonic hedgehog (SHH) oral squamous cell carcinoma (OSCC) tumor microenvironment (TME) tumor-associated macrophages (TAMs) cancer-associated fibroblasts (CAFs) tumor-associated angiogenesis hedgehog growth plate endochondral ossification chondrocyte osteoblast bone disease TMJ synovial joint articular disc Ihh PTHrP osteoarthritis epithelial–mesenchymal interaction (EMI) prostate cancer external genitalia androgen basement membrane bone morphogenetic protein stem cell animal experiment fracture healing cancer stem cells hypospadias urethra penis bone hedgehog signalling tooth development epithelial and mesenchymal interaction Gli1 mesenchymal stem cell lineage tracing analysis stem cell marker n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | Cyp26 enzymes congenital anomalies CRE/LoxP hedgehog signaling mouse models retinoic acid smoothened sonic hedgehog sonic hedgehog (SHH) oral squamous cell carcinoma (OSCC) tumor microenvironment (TME) tumor-associated macrophages (TAMs) cancer-associated fibroblasts (CAFs) tumor-associated angiogenesis hedgehog growth plate endochondral ossification chondrocyte osteoblast bone disease TMJ synovial joint articular disc Ihh PTHrP osteoarthritis epithelial–mesenchymal interaction (EMI) prostate cancer external genitalia androgen basement membrane bone morphogenetic protein stem cell animal experiment fracture healing cancer stem cells hypospadias urethra penis bone hedgehog signalling tooth development epithelial and mesenchymal interaction Gli1 mesenchymal stem cell lineage tracing analysis stem cell marker n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039362608_913 |