Adipose-Derived Stromal/Stem Cells
Adipose tissue is a rich, ubiquitous, and easily accessible source for multipotent mesenchymal stromal/stem cells (MSCs), so-called adipose-derived stromal/stem cells (ASCs). Primary isolated ASCs are a heterogeneous preparation consisting of several subpopulations of stromal/stem and precursor cell...
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| フォーマット: | Online |
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| 言語: | 英語 |
| 出版事項: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| 主題: | |
| オンライン･アクセス: | ONIX_20210501_9783039432820_992 |
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| _version_ | 1869523614783504384 |
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| collection | Directory of Open Access Books |
| description | Adipose tissue is a rich, ubiquitous, and easily accessible source for multipotent mesenchymal stromal/stem cells (MSCs), so-called adipose-derived stromal/stem cells (ASCs). Primary isolated ASCs are a heterogeneous preparation consisting of several subpopulations of stromal/stem and precursor cells. Donor-specific differences in ASC isolations and the lack of culture standardization hinder the comparison of results from different studies. Nevertheless, ASCs are already being used in different in vivo models and clinical trials to investigate their ability to improve tissue and organ regeneration. Many questions concerning their counterparts and biology in situ, their differentiation potential in vitro and in vivo, and the mechanisms of regeneration (paracrine effects, including regeneration-promoting factors and extracellular vesicles, differentiation, and immunomodulation) are not completely understood or remain unanswered. This Special Issue covers research articles investigating various adipose tissues as a source for ASC isolation, specific cultures methods to enhance proliferation or viability, and the differentiation capacity. Furthermore, other studies highlight aspects of various diseases, the immunosuppressive potential of ASCs and their derivates, or the in vivo tracking of transplanted ASCs. This edition is complemented by a review that summarizes the current knowledge of spheroid culture system methods and applications for mesenchymal stem cells. |
| format | Online |
| id | doab-20.500.12854ir-69246 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-692462024-03-31T13:09:53Z Adipose-Derived Stromal/Stem Cells Baer, Patrick C. lipomas adipose tissue stem cells adipogenesis osteogenesis mesenchymal stem cells T-cells conditioned medium extracellular vesicles TLR INF-γ adipose-derived stromal cells equine metabolic syndrome metformin adipose-derived stem cells adipocytes differentiation collagen I adiponectin integrins discoidin domain-containing receptor ageing subcutaneous fat adipose tissue-derived mesenchymal stromal/stem cells (ASCs) cell differentiation volatile organic compounds metabolic monitoring adipose-derived stromal/stem cells chondrogenesis colony forming unit-fibroblast fetal bovine serum human platelet lysate mesenchymal stem cell regenerative medicine human adipose-derived stem cells stem cell proliferation signaling pathway adipose-derived mesenchymal stem cells migration secretion primary cilium sonic hedgehog signaling mesenchymal stromal/stem cells perirenal fat characterization stimulation lipopolysaccharide cytokines cytomegalovirus angiogenesis adipose derived mesenchymal cells Histogel 3D cell culture spheroid culture biomaterials phenotype secretory potential ankylosing spondylitis systemic lupus erythematosus systemic sclerosis mesenchymal stromal cells breast cancer tumor microenvironment perineural invasion adipose derived stem cells valproic acid protein interactions MAPK pathway JAK/STAT pathway mesenchymal stromal cell tissue of origin prolonged culture epigenetic memory tracking bio imaging bioluminescence qRT-PCR Ataxia telangiectasia Atm n/a thema EDItEUR::M Medicine and Nursing Adipose tissue is a rich, ubiquitous, and easily accessible source for multipotent mesenchymal stromal/stem cells (MSCs), so-called adipose-derived stromal/stem cells (ASCs). Primary isolated ASCs are a heterogeneous preparation consisting of several subpopulations of stromal/stem and precursor cells. Donor-specific differences in ASC isolations and the lack of culture standardization hinder the comparison of results from different studies. Nevertheless, ASCs are already being used in different in vivo models and clinical trials to investigate their ability to improve tissue and organ regeneration. Many questions concerning their counterparts and biology in situ, their differentiation potential in vitro and in vivo, and the mechanisms of regeneration (paracrine effects, including regeneration-promoting factors and extracellular vesicles, differentiation, and immunomodulation) are not completely understood or remain unanswered. This Special Issue covers research articles investigating various adipose tissues as a source for ASC isolation, specific cultures methods to enhance proliferation or viability, and the differentiation capacity. Furthermore, other studies highlight aspects of various diseases, the immunosuppressive potential of ASCs and their derivates, or the in vivo tracking of transplanted ASCs. This edition is complemented by a review that summarizes the current knowledge of spheroid culture system methods and applications for mesenchymal stem cells. 2021-05-01T15:44:38Z 2021-05-01T15:44:38Z 2020 book ONIX_20210501_9783039432820_992 9783039432820 9783039432837 https://directory.doabooks.org/handle/20.500.12854/69246 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3029 https://mdpi.com/books/pdfview/book/3029 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03943-283-7 10.3390/books978-3-03943-283-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039432820 9783039432837 286 Basel, Switzerland open access |
| spellingShingle | lipomas adipose tissue stem cells adipogenesis osteogenesis mesenchymal stem cells T-cells conditioned medium extracellular vesicles TLR INF-γ adipose-derived stromal cells equine metabolic syndrome metformin adipose-derived stem cells adipocytes differentiation collagen I adiponectin integrins discoidin domain-containing receptor ageing subcutaneous fat adipose tissue-derived mesenchymal stromal/stem cells (ASCs) cell differentiation volatile organic compounds metabolic monitoring adipose-derived stromal/stem cells chondrogenesis colony forming unit-fibroblast fetal bovine serum human platelet lysate mesenchymal stem cell regenerative medicine human adipose-derived stem cells stem cell proliferation signaling pathway adipose-derived mesenchymal stem cells migration secretion primary cilium sonic hedgehog signaling mesenchymal stromal/stem cells perirenal fat characterization stimulation lipopolysaccharide cytokines cytomegalovirus angiogenesis adipose derived mesenchymal cells Histogel 3D cell culture spheroid culture biomaterials phenotype secretory potential ankylosing spondylitis systemic lupus erythematosus systemic sclerosis mesenchymal stromal cells breast cancer tumor microenvironment perineural invasion adipose derived stem cells valproic acid protein interactions MAPK pathway JAK/STAT pathway mesenchymal stromal cell tissue of origin prolonged culture epigenetic memory tracking bio imaging bioluminescence qRT-PCR Ataxia telangiectasia Atm n/a thema EDItEUR::M Medicine and Nursing Adipose-Derived Stromal/Stem Cells |
| title | Adipose-Derived Stromal/Stem Cells |
| title_full | Adipose-Derived Stromal/Stem Cells |
| title_fullStr | Adipose-Derived Stromal/Stem Cells |
| title_full_unstemmed | Adipose-Derived Stromal/Stem Cells |
| title_short | Adipose-Derived Stromal/Stem Cells |
| title_sort | adipose derived stromal stem cells |
| topic | lipomas adipose tissue stem cells adipogenesis osteogenesis mesenchymal stem cells T-cells conditioned medium extracellular vesicles TLR INF-γ adipose-derived stromal cells equine metabolic syndrome metformin adipose-derived stem cells adipocytes differentiation collagen I adiponectin integrins discoidin domain-containing receptor ageing subcutaneous fat adipose tissue-derived mesenchymal stromal/stem cells (ASCs) cell differentiation volatile organic compounds metabolic monitoring adipose-derived stromal/stem cells chondrogenesis colony forming unit-fibroblast fetal bovine serum human platelet lysate mesenchymal stem cell regenerative medicine human adipose-derived stem cells stem cell proliferation signaling pathway adipose-derived mesenchymal stem cells migration secretion primary cilium sonic hedgehog signaling mesenchymal stromal/stem cells perirenal fat characterization stimulation lipopolysaccharide cytokines cytomegalovirus angiogenesis adipose derived mesenchymal cells Histogel 3D cell culture spheroid culture biomaterials phenotype secretory potential ankylosing spondylitis systemic lupus erythematosus systemic sclerosis mesenchymal stromal cells breast cancer tumor microenvironment perineural invasion adipose derived stem cells valproic acid protein interactions MAPK pathway JAK/STAT pathway mesenchymal stromal cell tissue of origin prolonged culture epigenetic memory tracking bio imaging bioluminescence qRT-PCR Ataxia telangiectasia Atm n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | lipomas adipose tissue stem cells adipogenesis osteogenesis mesenchymal stem cells T-cells conditioned medium extracellular vesicles TLR INF-γ adipose-derived stromal cells equine metabolic syndrome metformin adipose-derived stem cells adipocytes differentiation collagen I adiponectin integrins discoidin domain-containing receptor ageing subcutaneous fat adipose tissue-derived mesenchymal stromal/stem cells (ASCs) cell differentiation volatile organic compounds metabolic monitoring adipose-derived stromal/stem cells chondrogenesis colony forming unit-fibroblast fetal bovine serum human platelet lysate mesenchymal stem cell regenerative medicine human adipose-derived stem cells stem cell proliferation signaling pathway adipose-derived mesenchymal stem cells migration secretion primary cilium sonic hedgehog signaling mesenchymal stromal/stem cells perirenal fat characterization stimulation lipopolysaccharide cytokines cytomegalovirus angiogenesis adipose derived mesenchymal cells Histogel 3D cell culture spheroid culture biomaterials phenotype secretory potential ankylosing spondylitis systemic lupus erythematosus systemic sclerosis mesenchymal stromal cells breast cancer tumor microenvironment perineural invasion adipose derived stem cells valproic acid protein interactions MAPK pathway JAK/STAT pathway mesenchymal stromal cell tissue of origin prolonged culture epigenetic memory tracking bio imaging bioluminescence qRT-PCR Ataxia telangiectasia Atm n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039432820_992 |