Arteriogenesis and Therapeutic Neovascularization
For many years, arteriogenesis, also called collateral formation, has been regarded as being a beneficial process to restore blood flow to distal tissues in occluded arteries. Therefore, it is frequently referred to in relation to therapeutic angiogenesis. Despite the big clinical potential and the...
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| Materyal Türü: | Online |
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| Dil: | İngilizce |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Online Erişim: | ONIX_20210501_9783039365937_1002 |
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| _version_ | 1869519265754775552 |
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| collection | Directory of Open Access Books |
| description | For many years, arteriogenesis, also called collateral formation, has been regarded as being a beneficial process to restore blood flow to distal tissues in occluded arteries. Therefore, it is frequently referred to in relation to therapeutic angiogenesis. Despite the big clinical potential and the many promising clinical trials on arteriogenesis and therapeutic angiogenesis, the exact molecular mechanisms involved in the multifactorial processes of arteriogenesis are still not completely understood. A better understanding is needed in order to define successful clinical therapies. In this Special Issue, multiple aspects of arteriogenesis and therapeutic angiogenesis will be addressed, ranging from the role of inflammatory processes and immune cells, to growth factors, microRNAs and environmental factors like hypoxia. Therapeutic angiogenesis will also be discussed in relation to the atherosclerosis and intraplaque angiogenesis in hypoxic lesions, as well as specific forms of arteriogenesis in relation to spinal cord blood supply and aorta surgery. The effects of exercise, a frequently prescribed therapy for PAD patients, on arteriogenesis are also discussed. Overall, the papers in this Special Issue on arteriogenesis and therapeutic angiogenesis provide important new insights in the underlying pathophysiological mechanism of these complex processes and may be helpful to define a successful future intervention directed at therapeutic angiogenesis. |
| format | Online |
| id | doab-20.500.12854ir-69256 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-692562024-03-30T23:22:28Z Arteriogenesis and Therapeutic Neovascularization Deindl, Elisabeth Quax, Paul Waltenberger, Johannes Schmitz-Rixen, Thomas factor VII activating protease HABP2 VEGF matrigel neo-vascularization hind limb ischemia angiogenesis arteriogenesis ERK endothelial cells inflammation macrophages atherosclerosis pericyte rAAV capillary microRNA isomiRs epitranscriptome neovascularization A-to-I editing m6A RNA modifications RNA methylation lower extremity arterial disease peripheral arterial disease blood flow restriction activity-based benefits training effects effect mechanism hyperoxygenation vein graft disease vascular biology spinal cord ischemia paraplegia aortic disease TAAA collateral network paraspinous compartment NO NOTCH innate immunity mast cell GH and eNOS IGF-I oxidative stress and arterial inflammation vascular homeostasis GHAS trial collateral artery growth SMC proliferation potassium channel KV1.3 KCa3.1 FGFR-1 Egr-1 PDFG-R αSM-actin TLR2/6 femoral artery ligation blood flow recovery collateral growth VHL loss of function microRNA-212/132 n/a thema EDItEUR::M Medicine and Nursing For many years, arteriogenesis, also called collateral formation, has been regarded as being a beneficial process to restore blood flow to distal tissues in occluded arteries. Therefore, it is frequently referred to in relation to therapeutic angiogenesis. Despite the big clinical potential and the many promising clinical trials on arteriogenesis and therapeutic angiogenesis, the exact molecular mechanisms involved in the multifactorial processes of arteriogenesis are still not completely understood. A better understanding is needed in order to define successful clinical therapies. In this Special Issue, multiple aspects of arteriogenesis and therapeutic angiogenesis will be addressed, ranging from the role of inflammatory processes and immune cells, to growth factors, microRNAs and environmental factors like hypoxia. Therapeutic angiogenesis will also be discussed in relation to the atherosclerosis and intraplaque angiogenesis in hypoxic lesions, as well as specific forms of arteriogenesis in relation to spinal cord blood supply and aorta surgery. The effects of exercise, a frequently prescribed therapy for PAD patients, on arteriogenesis are also discussed. Overall, the papers in this Special Issue on arteriogenesis and therapeutic angiogenesis provide important new insights in the underlying pathophysiological mechanism of these complex processes and may be helpful to define a successful future intervention directed at therapeutic angiogenesis. 2021-05-01T15:45:06Z 2021-05-01T15:45:06Z 2020 book ONIX_20210501_9783039365937_1002 9783039365937 9783039365944 https://directory.doabooks.org/handle/20.500.12854/69256 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3044 https://mdpi.com/books/pdfview/book/3044 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03936-594-4 10.3390/books978-3-03936-594-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039365937 9783039365944 220 Basel, Switzerland open access |
| spellingShingle | factor VII activating protease HABP2 VEGF matrigel neo-vascularization hind limb ischemia angiogenesis arteriogenesis ERK endothelial cells inflammation macrophages atherosclerosis pericyte rAAV capillary microRNA isomiRs epitranscriptome neovascularization A-to-I editing m6A RNA modifications RNA methylation lower extremity arterial disease peripheral arterial disease blood flow restriction activity-based benefits training effects effect mechanism hyperoxygenation vein graft disease vascular biology spinal cord ischemia paraplegia aortic disease TAAA collateral network paraspinous compartment NO NOTCH innate immunity mast cell GH and eNOS IGF-I oxidative stress and arterial inflammation vascular homeostasis GHAS trial collateral artery growth SMC proliferation potassium channel KV1.3 KCa3.1 FGFR-1 Egr-1 PDFG-R αSM-actin TLR2/6 femoral artery ligation blood flow recovery collateral growth VHL loss of function microRNA-212/132 n/a thema EDItEUR::M Medicine and Nursing Arteriogenesis and Therapeutic Neovascularization |
| title | Arteriogenesis and Therapeutic Neovascularization |
| title_full | Arteriogenesis and Therapeutic Neovascularization |
| title_fullStr | Arteriogenesis and Therapeutic Neovascularization |
| title_full_unstemmed | Arteriogenesis and Therapeutic Neovascularization |
| title_short | Arteriogenesis and Therapeutic Neovascularization |
| title_sort | arteriogenesis and therapeutic neovascularization |
| topic | factor VII activating protease HABP2 VEGF matrigel neo-vascularization hind limb ischemia angiogenesis arteriogenesis ERK endothelial cells inflammation macrophages atherosclerosis pericyte rAAV capillary microRNA isomiRs epitranscriptome neovascularization A-to-I editing m6A RNA modifications RNA methylation lower extremity arterial disease peripheral arterial disease blood flow restriction activity-based benefits training effects effect mechanism hyperoxygenation vein graft disease vascular biology spinal cord ischemia paraplegia aortic disease TAAA collateral network paraspinous compartment NO NOTCH innate immunity mast cell GH and eNOS IGF-I oxidative stress and arterial inflammation vascular homeostasis GHAS trial collateral artery growth SMC proliferation potassium channel KV1.3 KCa3.1 FGFR-1 Egr-1 PDFG-R αSM-actin TLR2/6 femoral artery ligation blood flow recovery collateral growth VHL loss of function microRNA-212/132 n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | factor VII activating protease HABP2 VEGF matrigel neo-vascularization hind limb ischemia angiogenesis arteriogenesis ERK endothelial cells inflammation macrophages atherosclerosis pericyte rAAV capillary microRNA isomiRs epitranscriptome neovascularization A-to-I editing m6A RNA modifications RNA methylation lower extremity arterial disease peripheral arterial disease blood flow restriction activity-based benefits training effects effect mechanism hyperoxygenation vein graft disease vascular biology spinal cord ischemia paraplegia aortic disease TAAA collateral network paraspinous compartment NO NOTCH innate immunity mast cell GH and eNOS IGF-I oxidative stress and arterial inflammation vascular homeostasis GHAS trial collateral artery growth SMC proliferation potassium channel KV1.3 KCa3.1 FGFR-1 Egr-1 PDFG-R αSM-actin TLR2/6 femoral artery ligation blood flow recovery collateral growth VHL loss of function microRNA-212/132 n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039365937_1002 |