Periodontitis
Periodontitis is an infection-induced inflammatory disease accounting for huge healthcare costs and socio-economic impacts. Bacteria from the indigenous oral flora colonize the interspace between the tooth and the connective tissue, which induces an inflammatory response. If the bacteria proliferate...
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| Ձևաչափ: | Online |
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| Լեզու: | անգլերեն |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Խորագրեր: | |
| Առցանց հասանելիություն: | ONIX_20210501_9783039435074_1043 |
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Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
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| _version_ | 1869525612270452736 |
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| collection | Directory of Open Access Books |
| description | Periodontitis is an infection-induced inflammatory disease accounting for huge healthcare costs and socio-economic impacts. Bacteria from the indigenous oral flora colonize the interspace between the tooth and the connective tissue, which induces an inflammatory response. If the bacteria proliferate and release virulence factors, they cause an imbalance in the host inflammatory response that induces degenerative processes in the surrounding tissues. This process is often slow, and the disease affects mainly older people, but the process could be rapid and affect young individuals if certain pathogens colonize the area. The two most studied periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, express virulence factors, including proteases and exotoxins. Periodontal bacteria and their products can be translocated to the peripheral circulation and are therefore linked to the risk pattern of several systemic diseases. However, it is not known if the increased risk for systemic disease associated with periodontitis is an effect of the invading bacteria and/or their released products, the release of components from the local inflammatory response, or a common host susceptibility pattern. The most studied periodontitis-associated systemic diseases are cardiovascular diseases and rheumatoid arthritis. Here, we want to shed light on mechanisms behind the associations of periodontal infections with systemic inflammation. |
| format | Online |
| id | doab-20.500.12854ir-69297 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-692972024-03-31T13:08:59Z Periodontitis Johansson, Anders apical periodontitis adaptive immunity saliva serum antibody Aggregatibacter actinomycetemcomitans invasiveness leukotoxin cytolethal distending toxin serum resistance outer membrane vesicles oral microbiome nitric oxide nitrate nitrite periodontal disease alveolar bone loss gingiva bacteria biofilm immunity inflammation smoking Rheumatoid arthritis Porphyromonas gingivalis periodontitis citrullination peptidylarginine deiminase ACPA anti-CCP host response infection oral microbiota virulence factors metabolites TREM-1 intervention LP17 IL-17 RANKL OPG cardiovascular diseases rheumatoid arthritis inflammatory response thema EDItEUR::M Medicine and Nursing Periodontitis is an infection-induced inflammatory disease accounting for huge healthcare costs and socio-economic impacts. Bacteria from the indigenous oral flora colonize the interspace between the tooth and the connective tissue, which induces an inflammatory response. If the bacteria proliferate and release virulence factors, they cause an imbalance in the host inflammatory response that induces degenerative processes in the surrounding tissues. This process is often slow, and the disease affects mainly older people, but the process could be rapid and affect young individuals if certain pathogens colonize the area. The two most studied periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, express virulence factors, including proteases and exotoxins. Periodontal bacteria and their products can be translocated to the peripheral circulation and are therefore linked to the risk pattern of several systemic diseases. However, it is not known if the increased risk for systemic disease associated with periodontitis is an effect of the invading bacteria and/or their released products, the release of components from the local inflammatory response, or a common host susceptibility pattern. The most studied periodontitis-associated systemic diseases are cardiovascular diseases and rheumatoid arthritis. Here, we want to shed light on mechanisms behind the associations of periodontal infections with systemic inflammation. 2021-05-01T15:46:06Z 2021-05-01T15:46:06Z 2020 book ONIX_20210501_9783039435074_1043 9783039435074 9783039435081 https://directory.doabooks.org/handle/20.500.12854/69297 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3087 https://mdpi.com/books/pdfview/book/3087 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03943-508-1 10.3390/books978-3-03943-508-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039435074 9783039435081 122 Basel, Switzerland open access |
| spellingShingle | apical periodontitis adaptive immunity saliva serum antibody Aggregatibacter actinomycetemcomitans invasiveness leukotoxin cytolethal distending toxin serum resistance outer membrane vesicles oral microbiome nitric oxide nitrate nitrite periodontal disease alveolar bone loss gingiva bacteria biofilm immunity inflammation smoking Rheumatoid arthritis Porphyromonas gingivalis periodontitis citrullination peptidylarginine deiminase ACPA anti-CCP host response infection oral microbiota virulence factors metabolites TREM-1 intervention LP17 IL-17 RANKL OPG cardiovascular diseases rheumatoid arthritis inflammatory response thema EDItEUR::M Medicine and Nursing Periodontitis |
| title | Periodontitis |
| title_full | Periodontitis |
| title_fullStr | Periodontitis |
| title_full_unstemmed | Periodontitis |
| title_short | Periodontitis |
| title_sort | periodontitis |
| topic | apical periodontitis adaptive immunity saliva serum antibody Aggregatibacter actinomycetemcomitans invasiveness leukotoxin cytolethal distending toxin serum resistance outer membrane vesicles oral microbiome nitric oxide nitrate nitrite periodontal disease alveolar bone loss gingiva bacteria biofilm immunity inflammation smoking Rheumatoid arthritis Porphyromonas gingivalis periodontitis citrullination peptidylarginine deiminase ACPA anti-CCP host response infection oral microbiota virulence factors metabolites TREM-1 intervention LP17 IL-17 RANKL OPG cardiovascular diseases rheumatoid arthritis inflammatory response thema EDItEUR::M Medicine and Nursing |
| topic_facet | apical periodontitis adaptive immunity saliva serum antibody Aggregatibacter actinomycetemcomitans invasiveness leukotoxin cytolethal distending toxin serum resistance outer membrane vesicles oral microbiome nitric oxide nitrate nitrite periodontal disease alveolar bone loss gingiva bacteria biofilm immunity inflammation smoking Rheumatoid arthritis Porphyromonas gingivalis periodontitis citrullination peptidylarginine deiminase ACPA anti-CCP host response infection oral microbiota virulence factors metabolites TREM-1 intervention LP17 IL-17 RANKL OPG cardiovascular diseases rheumatoid arthritis inflammatory response thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039435074_1043 |