Genomics and Models of Nerve Sheath Tumors
Nerve sheath tumors can be a significant cause of morbidity for many patients. These include benign tumors such as schwannomas, diffuse and plexiform neurofibromas, and atypical neurofibromas, as well as the aggressive soft tissue sarcoma known as the malignant peripheral nerve sheath tumor (MPNST)....
Na minha lista:
| Formato: | Online |
|---|---|
| Idioma: | inglês |
| Publicado em: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
|
| Assuntos: | |
| Acesso em linha: | ONIX_20210501_9783039434893_1046 |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|
| _version_ | 1869526103995973632 |
|---|---|
| collection | Directory of Open Access Books |
| description | Nerve sheath tumors can be a significant cause of morbidity for many patients. These include benign tumors such as schwannomas, diffuse and plexiform neurofibromas, and atypical neurofibromas, as well as the aggressive soft tissue sarcoma known as the malignant peripheral nerve sheath tumor (MPNST). Nerve sheath tumors occur sporadically and in the context of the clinical neuro-genetic tumor predisposition syndromes neurofibromatosis type 1 (NF1) and type 2 (NF2). Historically, the mainstay of treatment for nerve sheath tumors has been surgery. However, for both benign and malignant nerve sheath tumors, there is a high recurrence rate, highlighting the pressing need for novel therapies. As we have entered the genomic era, the hope is that an improved understanding of the genetics, and therefore the biology, of these tumors will ultimately lead to therapies that result in better outcomes. In this Special Issue, we include both review articles and original research related to the genomic understanding and modeling of schwannomas, plexiform and diffuse neurofibromas, atypical neurofibromas, and malignant peripheral nerve sheath tumors as well as genomic methods being developed and applied to advance our understanding of these tumors. |
| format | Online |
| id | doab-20.500.12854ir-69300 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-693002024-03-31T13:09:44Z Genomics and Models of Nerve Sheath Tumors Hirbe, Angela C. Pratilas, Christine A. Dodd, Rebecca D. neurofibromatosis type 1 nerve sheath tumor cancer latent variables machine learning supervised learning transfer learning random forest metaVIPER tumor deconvolution neurofibromatosis malignant peripheral nerve sheath tumor MPNST polycomb repressive complex PRC2 NF1 kinase kinome adaptation kinome reprogramming MET MEK doxorubicin capmatinib tram genomics tumor evolution pathology next generation sequencing clinical genetics malignant peripheral nerve sheath tumors plexiform neurofibromas Schwann cells neurofibromatosis type 1 syndrome neurofibromin 1 genetically engineered mouse models heterogeneity CRISPR/Cas9 mouse models sarcoma tumor microenvironment neurofibromatosis 1 (NF1) mebendazole (MBZ) COX-2 inhibitor malignancy chemoprevention nerve sheath tumors thema EDItEUR::M Medicine and Nursing Nerve sheath tumors can be a significant cause of morbidity for many patients. These include benign tumors such as schwannomas, diffuse and plexiform neurofibromas, and atypical neurofibromas, as well as the aggressive soft tissue sarcoma known as the malignant peripheral nerve sheath tumor (MPNST). Nerve sheath tumors occur sporadically and in the context of the clinical neuro-genetic tumor predisposition syndromes neurofibromatosis type 1 (NF1) and type 2 (NF2). Historically, the mainstay of treatment for nerve sheath tumors has been surgery. However, for both benign and malignant nerve sheath tumors, there is a high recurrence rate, highlighting the pressing need for novel therapies. As we have entered the genomic era, the hope is that an improved understanding of the genetics, and therefore the biology, of these tumors will ultimately lead to therapies that result in better outcomes. In this Special Issue, we include both review articles and original research related to the genomic understanding and modeling of schwannomas, plexiform and diffuse neurofibromas, atypical neurofibromas, and malignant peripheral nerve sheath tumors as well as genomic methods being developed and applied to advance our understanding of these tumors. 2021-05-01T15:46:10Z 2021-05-01T15:46:10Z 2020 book ONIX_20210501_9783039434893_1046 9783039434893 9783039434909 https://directory.doabooks.org/handle/20.500.12854/69300 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3090 https://mdpi.com/books/pdfview/book/3090 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03943-490-9 10.3390/books978-3-03943-490-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039434893 9783039434909 172 Basel, Switzerland open access |
| spellingShingle | neurofibromatosis type 1 nerve sheath tumor cancer latent variables machine learning supervised learning transfer learning random forest metaVIPER tumor deconvolution neurofibromatosis malignant peripheral nerve sheath tumor MPNST polycomb repressive complex PRC2 NF1 kinase kinome adaptation kinome reprogramming MET MEK doxorubicin capmatinib tram genomics tumor evolution pathology next generation sequencing clinical genetics malignant peripheral nerve sheath tumors plexiform neurofibromas Schwann cells neurofibromatosis type 1 syndrome neurofibromin 1 genetically engineered mouse models heterogeneity CRISPR/Cas9 mouse models sarcoma tumor microenvironment neurofibromatosis 1 (NF1) mebendazole (MBZ) COX-2 inhibitor malignancy chemoprevention nerve sheath tumors thema EDItEUR::M Medicine and Nursing Genomics and Models of Nerve Sheath Tumors |
| title | Genomics and Models of Nerve Sheath Tumors |
| title_full | Genomics and Models of Nerve Sheath Tumors |
| title_fullStr | Genomics and Models of Nerve Sheath Tumors |
| title_full_unstemmed | Genomics and Models of Nerve Sheath Tumors |
| title_short | Genomics and Models of Nerve Sheath Tumors |
| title_sort | genomics and models of nerve sheath tumors |
| topic | neurofibromatosis type 1 nerve sheath tumor cancer latent variables machine learning supervised learning transfer learning random forest metaVIPER tumor deconvolution neurofibromatosis malignant peripheral nerve sheath tumor MPNST polycomb repressive complex PRC2 NF1 kinase kinome adaptation kinome reprogramming MET MEK doxorubicin capmatinib tram genomics tumor evolution pathology next generation sequencing clinical genetics malignant peripheral nerve sheath tumors plexiform neurofibromas Schwann cells neurofibromatosis type 1 syndrome neurofibromin 1 genetically engineered mouse models heterogeneity CRISPR/Cas9 mouse models sarcoma tumor microenvironment neurofibromatosis 1 (NF1) mebendazole (MBZ) COX-2 inhibitor malignancy chemoprevention nerve sheath tumors thema EDItEUR::M Medicine and Nursing |
| topic_facet | neurofibromatosis type 1 nerve sheath tumor cancer latent variables machine learning supervised learning transfer learning random forest metaVIPER tumor deconvolution neurofibromatosis malignant peripheral nerve sheath tumor MPNST polycomb repressive complex PRC2 NF1 kinase kinome adaptation kinome reprogramming MET MEK doxorubicin capmatinib tram genomics tumor evolution pathology next generation sequencing clinical genetics malignant peripheral nerve sheath tumors plexiform neurofibromas Schwann cells neurofibromatosis type 1 syndrome neurofibromin 1 genetically engineered mouse models heterogeneity CRISPR/Cas9 mouse models sarcoma tumor microenvironment neurofibromatosis 1 (NF1) mebendazole (MBZ) COX-2 inhibitor malignancy chemoprevention nerve sheath tumors thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039434893_1046 |