Radiolabelled Molecules for Brain Imaging with PET and SPECT
Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are in vivo molecular imaging methods which are widely used in nuclear medicine for diagnosis and treatment follow-up of many major diseases. These methods use target-specific molecules as probes, which are lab...
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| Формат: | Online |
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| Язык: | английский |
| Опубликовано: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Предметы: | |
| Online-ссылка: | ONIX_20210501_9783039367207_1094 |
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| _version_ | 1869524047820226560 |
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| collection | Directory of Open Access Books |
| description | Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are in vivo molecular imaging methods which are widely used in nuclear medicine for diagnosis and treatment follow-up of many major diseases. These methods use target-specific molecules as probes, which are labeled with radionuclides of short half-lives that are synthesized prior to the imaging studies. These probes are called radiopharmaceuticals. The use of PET and SPECT for brain imaging is of special significance since the brain controls all the body’s functions by processing information from the whole body and the outside world. It is the source of thoughts, intelligence, memory, speech, creativity, emotion, sensory functions, motion control, and other important body functions. Protected by the skull and the blood–brain barrier, the brain is somehow a privileged organ with regard to nutrient supply, immune response, and accessibility for diagnostic and therapeutic measures. Invasive procedures are rather limited for the latter purposes. Therefore, noninvasive imaging with PET and SPECT has gained high importance for a great variety of brain diseases, including neurodegenerative diseases, motor dysfunctions, stroke, epilepsy, psychiatric diseases, and brain tumors. This Special Issue focuses on radiolabeled molecules that are used for these purposes, with special emphasis on neurodegenerative diseases and brain tumors. |
| format | Online |
| id | doab-20.500.12854ir-69348 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-693482024-03-28T03:33:40Z Radiolabelled Molecules for Brain Imaging with PET and SPECT Brust, Peter SV2A SV2B SV2C microPET [18F]UCB-H epilepsy PBIF distribution volume blocking assay preclinical imaging Alzheimer’s disease (AD) network measure graph theory brain network positron emission tomography (PET) persistent homology Phosphodiesterase 2A (PDE2A) Positron Emission Tomography (PET) Benzoimidazotriazine (BIT) fluorinated Mouse Liver Microsomes (MLM) cyclic nucleotide phosphodiesterase PDE2A radioligand nitro-precursor fluorine-18 in vitro autoradiography PET imaging opioid receptors positron emission tomography radiotracers μOR-, δOR-, κOR- and ORL1-ligands movement disorders pain drug dependence GBM biomarkers Sigma 1 Sigma 2 PD-L1 PARP IDH Alzheimer’s disease Parkinson’s disease β-amyloid plaques neurofibrillary tangles α-synucleinopathy diagnostic imaging probes orexin receptors PET radiotracer imaging alpha 7 nicotinic acetylcholine receptors nAChR autoradiography amino acid FET FACBC FDOPA immunoPET molecular imaging glioma brain metastases adenosine A2A receptor rotenone-based mouse model [18F]FESCH two-step one-pot radiosynthesis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are in vivo molecular imaging methods which are widely used in nuclear medicine for diagnosis and treatment follow-up of many major diseases. These methods use target-specific molecules as probes, which are labeled with radionuclides of short half-lives that are synthesized prior to the imaging studies. These probes are called radiopharmaceuticals. The use of PET and SPECT for brain imaging is of special significance since the brain controls all the body’s functions by processing information from the whole body and the outside world. It is the source of thoughts, intelligence, memory, speech, creativity, emotion, sensory functions, motion control, and other important body functions. Protected by the skull and the blood–brain barrier, the brain is somehow a privileged organ with regard to nutrient supply, immune response, and accessibility for diagnostic and therapeutic measures. Invasive procedures are rather limited for the latter purposes. Therefore, noninvasive imaging with PET and SPECT has gained high importance for a great variety of brain diseases, including neurodegenerative diseases, motor dysfunctions, stroke, epilepsy, psychiatric diseases, and brain tumors. This Special Issue focuses on radiolabeled molecules that are used for these purposes, with special emphasis on neurodegenerative diseases and brain tumors. 2021-05-01T15:47:18Z 2021-05-01T15:47:18Z 2020 book ONIX_20210501_9783039367207_1094 9783039367207 9783039367214 https://directory.doabooks.org/handle/20.500.12854/69348 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3140 https://mdpi.com/books/pdfview/book/3140 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03936-721-4 10.3390/books978-3-03936-721-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039367207 9783039367214 244 Basel, Switzerland open access |
| spellingShingle | SV2A SV2B SV2C microPET [18F]UCB-H epilepsy PBIF distribution volume blocking assay preclinical imaging Alzheimer’s disease (AD) network measure graph theory brain network positron emission tomography (PET) persistent homology Phosphodiesterase 2A (PDE2A) Positron Emission Tomography (PET) Benzoimidazotriazine (BIT) fluorinated Mouse Liver Microsomes (MLM) cyclic nucleotide phosphodiesterase PDE2A radioligand nitro-precursor fluorine-18 in vitro autoradiography PET imaging opioid receptors positron emission tomography radiotracers μOR-, δOR-, κOR- and ORL1-ligands movement disorders pain drug dependence GBM biomarkers Sigma 1 Sigma 2 PD-L1 PARP IDH Alzheimer’s disease Parkinson’s disease β-amyloid plaques neurofibrillary tangles α-synucleinopathy diagnostic imaging probes orexin receptors PET radiotracer imaging alpha 7 nicotinic acetylcholine receptors nAChR autoradiography amino acid FET FACBC FDOPA immunoPET molecular imaging glioma brain metastases adenosine A2A receptor rotenone-based mouse model [18F]FESCH two-step one-pot radiosynthesis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Radiolabelled Molecules for Brain Imaging with PET and SPECT |
| title | Radiolabelled Molecules for Brain Imaging with PET and SPECT |
| title_full | Radiolabelled Molecules for Brain Imaging with PET and SPECT |
| title_fullStr | Radiolabelled Molecules for Brain Imaging with PET and SPECT |
| title_full_unstemmed | Radiolabelled Molecules for Brain Imaging with PET and SPECT |
| title_short | Radiolabelled Molecules for Brain Imaging with PET and SPECT |
| title_sort | radiolabelled molecules for brain imaging with pet and spect |
| topic | SV2A SV2B SV2C microPET [18F]UCB-H epilepsy PBIF distribution volume blocking assay preclinical imaging Alzheimer’s disease (AD) network measure graph theory brain network positron emission tomography (PET) persistent homology Phosphodiesterase 2A (PDE2A) Positron Emission Tomography (PET) Benzoimidazotriazine (BIT) fluorinated Mouse Liver Microsomes (MLM) cyclic nucleotide phosphodiesterase PDE2A radioligand nitro-precursor fluorine-18 in vitro autoradiography PET imaging opioid receptors positron emission tomography radiotracers μOR-, δOR-, κOR- and ORL1-ligands movement disorders pain drug dependence GBM biomarkers Sigma 1 Sigma 2 PD-L1 PARP IDH Alzheimer’s disease Parkinson’s disease β-amyloid plaques neurofibrillary tangles α-synucleinopathy diagnostic imaging probes orexin receptors PET radiotracer imaging alpha 7 nicotinic acetylcholine receptors nAChR autoradiography amino acid FET FACBC FDOPA immunoPET molecular imaging glioma brain metastases adenosine A2A receptor rotenone-based mouse model [18F]FESCH two-step one-pot radiosynthesis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | SV2A SV2B SV2C microPET [18F]UCB-H epilepsy PBIF distribution volume blocking assay preclinical imaging Alzheimer’s disease (AD) network measure graph theory brain network positron emission tomography (PET) persistent homology Phosphodiesterase 2A (PDE2A) Positron Emission Tomography (PET) Benzoimidazotriazine (BIT) fluorinated Mouse Liver Microsomes (MLM) cyclic nucleotide phosphodiesterase PDE2A radioligand nitro-precursor fluorine-18 in vitro autoradiography PET imaging opioid receptors positron emission tomography radiotracers μOR-, δOR-, κOR- and ORL1-ligands movement disorders pain drug dependence GBM biomarkers Sigma 1 Sigma 2 PD-L1 PARP IDH Alzheimer’s disease Parkinson’s disease β-amyloid plaques neurofibrillary tangles α-synucleinopathy diagnostic imaging probes orexin receptors PET radiotracer imaging alpha 7 nicotinic acetylcholine receptors nAChR autoradiography amino acid FET FACBC FDOPA immunoPET molecular imaging glioma brain metastases adenosine A2A receptor rotenone-based mouse model [18F]FESCH two-step one-pot radiosynthesis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20210501_9783039367207_1094 |