New Diagnostic and Therapeutic Approaches for the Care of the Severely Injured Patient
Trauma represents a leading cause of death, particularly in the younger population. Traumatic brain injury and hemorrhage are the most common causes of early death, whereas complications such as infections, (multi-)organ failure and “persistent inflammation, immunosuppression, and catabolism syndrom...
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| Format: | Online |
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| Jezik: | engleski |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Teme: | |
| Online pristup: | ONIX_20210501_9783039437771_1167 |
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| collection | Directory of Open Access Books |
| description | Trauma represents a leading cause of death, particularly in the younger population. Traumatic brain injury and hemorrhage are the most common causes of early death, whereas complications such as infections, (multi-)organ failure and “persistent inflammation, immunosuppression, and catabolism syndrome” (PICS) represent relevant factors for late adverse outcomes. Pre- and intra-hospital diagnostic and therapeutic standard operating procedures have been shown to beneficially influence posttraumatic outcome. However, development of patient-specific diagnostic and therapeutic strategies remains challenging due to uncertainties regarding the assessment of the individual risk profile. Furthermore, the relevance of prevention and rehabilitation measures to avoid unfavorable long-term consequences of trauma is not fully elucidated. With this Special Issue, we wanted to reflect the current knowledge about the pathomechanisms associated with the impact of severe injury and its consequences for the further clinical course on the one hand, and to point out new insights in regard to diagnostic and therapeutic approaches on the other hand. Furthermore, interesting aspects for future directions for the care of severely injured patients are illustrated. |
| format | Online |
| id | doab-20.500.12854ir-69421 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-694212024-03-30T23:22:36Z New Diagnostic and Therapeutic Approaches for the Care of the Severely Injured Patient Hildebrand, Frank Horst, Klemens PICS trauma immunology infectious complications virtual reality burn hand mTICCS TICCS massive transfusion shock multiple trauma polytrauma bleeding transfusion Arthroscopy-assisted corrective osteotomy tibial plateau malunion tibial plateau nonunion proliferation lymphocytes regulatory T cells IL-10 sepsis complement patients extracorporeal shock wave therapy hypertrophic scar hand function risk factors knee joint injuries knee dislocation ligament injuries traumatic brain injury (TBI) risk prediction biomarker IL-6 posttraumatic inflammation S100b NSE GFAP multiple-injured patient spine injury AOSpine classification time to surgery spinal cord injury rehabilitation exercises hemostasis venous thrombosis sarcopenia prevalence mortality skeletal mass index muscle mass intraoperative CT scan distal radius fracture O-arm radius fracture intraoperative CT scan in trauma DHEA steroids catecholamine health service research management of major trauma geriatric major trauma outcome research patient-reported outcome Polytrauma flail chest thoracic injury pubic ramus fractures fragility fractures of the pelvis living condition mobility quality of life trauma resuscitation unit emergency medicine injury severity abbreviated injury scale injury severity score pelvic fracture fragility fractures pelvic ring pelvic ring fracture insole-force sensors weight-bearing geriatric fracture cervical artery dissection vertebral artery carotid artery severely injured computed tomography sacroiliac-screw SI-screw percutaneous operation augmentation fragility fracture 3-D navigation airway management intubation laryngoscopy video prehospital care rescue helicopter air ambulance chest trauma weight disorders overweight obesity outcome thoracoabdominal aortic aneurysm ribonuclease ribonuclease inhibitor 1 complex aortic surgery acute kidney injury n/a thema EDItEUR::M Medicine and Nursing Trauma represents a leading cause of death, particularly in the younger population. Traumatic brain injury and hemorrhage are the most common causes of early death, whereas complications such as infections, (multi-)organ failure and “persistent inflammation, immunosuppression, and catabolism syndrome” (PICS) represent relevant factors for late adverse outcomes. Pre- and intra-hospital diagnostic and therapeutic standard operating procedures have been shown to beneficially influence posttraumatic outcome. However, development of patient-specific diagnostic and therapeutic strategies remains challenging due to uncertainties regarding the assessment of the individual risk profile. Furthermore, the relevance of prevention and rehabilitation measures to avoid unfavorable long-term consequences of trauma is not fully elucidated. With this Special Issue, we wanted to reflect the current knowledge about the pathomechanisms associated with the impact of severe injury and its consequences for the further clinical course on the one hand, and to point out new insights in regard to diagnostic and therapeutic approaches on the other hand. Furthermore, interesting aspects for future directions for the care of severely injured patients are illustrated. 2021-05-01T15:49:15Z 2021-05-01T15:49:15Z 2020 book ONIX_20210501_9783039437771_1167 9783039437771 9783039437788 https://directory.doabooks.org/handle/20.500.12854/69421 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/3223 https://mdpi.com/books/pdfview/book/3223 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03943-778-8 10.3390/books978-3-03943-778-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039437771 9783039437788 318 Basel, Switzerland open access |
| spellingShingle | PICS trauma immunology infectious complications virtual reality burn hand mTICCS TICCS massive transfusion shock multiple trauma polytrauma bleeding transfusion Arthroscopy-assisted corrective osteotomy tibial plateau malunion tibial plateau nonunion proliferation lymphocytes regulatory T cells IL-10 sepsis complement patients extracorporeal shock wave therapy hypertrophic scar hand function risk factors knee joint injuries knee dislocation ligament injuries traumatic brain injury (TBI) risk prediction biomarker IL-6 posttraumatic inflammation S100b NSE GFAP multiple-injured patient spine injury AOSpine classification time to surgery spinal cord injury rehabilitation exercises hemostasis venous thrombosis sarcopenia prevalence mortality skeletal mass index muscle mass intraoperative CT scan distal radius fracture O-arm radius fracture intraoperative CT scan in trauma DHEA steroids catecholamine health service research management of major trauma geriatric major trauma outcome research patient-reported outcome Polytrauma flail chest thoracic injury pubic ramus fractures fragility fractures of the pelvis living condition mobility quality of life trauma resuscitation unit emergency medicine injury severity abbreviated injury scale injury severity score pelvic fracture fragility fractures pelvic ring pelvic ring fracture insole-force sensors weight-bearing geriatric fracture cervical artery dissection vertebral artery carotid artery severely injured computed tomography sacroiliac-screw SI-screw percutaneous operation augmentation fragility fracture 3-D navigation airway management intubation laryngoscopy video prehospital care rescue helicopter air ambulance chest trauma weight disorders overweight obesity outcome thoracoabdominal aortic aneurysm ribonuclease ribonuclease inhibitor 1 complex aortic surgery acute kidney injury n/a thema EDItEUR::M Medicine and Nursing New Diagnostic and Therapeutic Approaches for the Care of the Severely Injured Patient |
| title | New Diagnostic and Therapeutic Approaches for the Care of the Severely Injured Patient |
| title_full | New Diagnostic and Therapeutic Approaches for the Care of the Severely Injured Patient |
| title_fullStr | New Diagnostic and Therapeutic Approaches for the Care of the Severely Injured Patient |
| title_full_unstemmed | New Diagnostic and Therapeutic Approaches for the Care of the Severely Injured Patient |
| title_short | New Diagnostic and Therapeutic Approaches for the Care of the Severely Injured Patient |
| title_sort | new diagnostic and therapeutic approaches for the care of the severely injured patient |
| topic | PICS trauma immunology infectious complications virtual reality burn hand mTICCS TICCS massive transfusion shock multiple trauma polytrauma bleeding transfusion Arthroscopy-assisted corrective osteotomy tibial plateau malunion tibial plateau nonunion proliferation lymphocytes regulatory T cells IL-10 sepsis complement patients extracorporeal shock wave therapy hypertrophic scar hand function risk factors knee joint injuries knee dislocation ligament injuries traumatic brain injury (TBI) risk prediction biomarker IL-6 posttraumatic inflammation S100b NSE GFAP multiple-injured patient spine injury AOSpine classification time to surgery spinal cord injury rehabilitation exercises hemostasis venous thrombosis sarcopenia prevalence mortality skeletal mass index muscle mass intraoperative CT scan distal radius fracture O-arm radius fracture intraoperative CT scan in trauma DHEA steroids catecholamine health service research management of major trauma geriatric major trauma outcome research patient-reported outcome Polytrauma flail chest thoracic injury pubic ramus fractures fragility fractures of the pelvis living condition mobility quality of life trauma resuscitation unit emergency medicine injury severity abbreviated injury scale injury severity score pelvic fracture fragility fractures pelvic ring pelvic ring fracture insole-force sensors weight-bearing geriatric fracture cervical artery dissection vertebral artery carotid artery severely injured computed tomography sacroiliac-screw SI-screw percutaneous operation augmentation fragility fracture 3-D navigation airway management intubation laryngoscopy video prehospital care rescue helicopter air ambulance chest trauma weight disorders overweight obesity outcome thoracoabdominal aortic aneurysm ribonuclease ribonuclease inhibitor 1 complex aortic surgery acute kidney injury n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | PICS trauma immunology infectious complications virtual reality burn hand mTICCS TICCS massive transfusion shock multiple trauma polytrauma bleeding transfusion Arthroscopy-assisted corrective osteotomy tibial plateau malunion tibial plateau nonunion proliferation lymphocytes regulatory T cells IL-10 sepsis complement patients extracorporeal shock wave therapy hypertrophic scar hand function risk factors knee joint injuries knee dislocation ligament injuries traumatic brain injury (TBI) risk prediction biomarker IL-6 posttraumatic inflammation S100b NSE GFAP multiple-injured patient spine injury AOSpine classification time to surgery spinal cord injury rehabilitation exercises hemostasis venous thrombosis sarcopenia prevalence mortality skeletal mass index muscle mass intraoperative CT scan distal radius fracture O-arm radius fracture intraoperative CT scan in trauma DHEA steroids catecholamine health service research management of major trauma geriatric major trauma outcome research patient-reported outcome Polytrauma flail chest thoracic injury pubic ramus fractures fragility fractures of the pelvis living condition mobility quality of life trauma resuscitation unit emergency medicine injury severity abbreviated injury scale injury severity score pelvic fracture fragility fractures pelvic ring pelvic ring fracture insole-force sensors weight-bearing geriatric fracture cervical artery dissection vertebral artery carotid artery severely injured computed tomography sacroiliac-screw SI-screw percutaneous operation augmentation fragility fracture 3-D navigation airway management intubation laryngoscopy video prehospital care rescue helicopter air ambulance chest trauma weight disorders overweight obesity outcome thoracoabdominal aortic aneurysm ribonuclease ribonuclease inhibitor 1 complex aortic surgery acute kidney injury n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039437771_1167 |