Chapter 3D Polarized Light Imaging Portrayed: Visualization of Fiber Architecture Derived from 3D-PLI
3D polarized light imaging (3D-PLI) is a neuroimaging technique that has recently opened up new avenues to study the complex architecture of nerve fibers in postmortem brains at microscopic scales. In a specific voxel-based analysis, each voxel is assigned a single 3D fiber orientation vector. This...
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| التنسيق: | Online |
| اللغة: | الإنجليزية |
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InTechOpen
2021
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| الوصول للمادة أونلاين: | ONIX_20210602_10.5772/intechopen.72532_378 |
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| _version_ | 1869523066312196096 |
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| author | Schubert, Nicole Axer, Markus Pietrzyk, Uwe Amunts, Katrin |
| author_browse | Amunts, Katrin Axer, Markus Pietrzyk, Uwe Schubert, Nicole |
| author_facet | Schubert, Nicole Axer, Markus Pietrzyk, Uwe Amunts, Katrin |
| author_sort | Schubert, Nicole |
| collection | Directory of Open Access Books |
| description | 3D polarized light imaging (3D-PLI) is a neuroimaging technique that has recently opened up new avenues to study the complex architecture of nerve fibers in postmortem brains at microscopic scales. In a specific voxel-based analysis, each voxel is assigned a single 3D fiber orientation vector. This leads to comprehensive 3D vector fields. In order to inspect and analyze such high-resolution fiber orientation vector field, also in combination with complementary microscopy measurements, appropriate visualization techniques are essential to overcome several challenges, such as the massive data sizes, the large amount of both unique and redundant information at different scales, or the occlusion issues of inner structures by outer layers. Here, we introduce a comprehensive software tool that is able to visualize all information of a typical 3D-PLI dataset in an adequate and sophisticated manner. This includes the visualization of (i) anatomic structural and fiber architectonic data in one representation, (ii) a large-scale fiber orientation vector field, and (iii) a clustered version of the field. Alignment of a 3D-PLI dataset to an appropriate brain atlas provides expert-based delineation, segmentation, and, ultimately, visualization of selected anatomical structures. By means of these techniques, a detailed analysis of the complex fiber architecture in 3D is feasible. |
| format | Online |
| id | doab-20.500.12854ir-70158 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-701582025-08-13T14:11:25Z Chapter 3D Polarized Light Imaging Portrayed: Visualization of Fiber Architecture Derived from 3D-PLI Schubert, Nicole Axer, Markus Pietrzyk, Uwe Amunts, Katrin polarized light imaging, scientific visualization, neuroinformatics, neuroimaging and fiber architecture thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences 3D polarized light imaging (3D-PLI) is a neuroimaging technique that has recently opened up new avenues to study the complex architecture of nerve fibers in postmortem brains at microscopic scales. In a specific voxel-based analysis, each voxel is assigned a single 3D fiber orientation vector. This leads to comprehensive 3D vector fields. In order to inspect and analyze such high-resolution fiber orientation vector field, also in combination with complementary microscopy measurements, appropriate visualization techniques are essential to overcome several challenges, such as the massive data sizes, the large amount of both unique and redundant information at different scales, or the occlusion issues of inner structures by outer layers. Here, we introduce a comprehensive software tool that is able to visualize all information of a typical 3D-PLI dataset in an adequate and sophisticated manner. This includes the visualization of (i) anatomic structural and fiber architectonic data in one representation, (ii) a large-scale fiber orientation vector field, and (iii) a clustered version of the field. Alignment of a 3D-PLI dataset to an appropriate brain atlas provides expert-based delineation, segmentation, and, ultimately, visualization of selected anatomical structures. By means of these techniques, a detailed analysis of the complex fiber architecture in 3D is feasible. 2021-02-10T12:58:18Z 2021-06-02T10:10:53Z 2018 chapter ONIX_20210602_10.5772/intechopen.72532_378 https://library.oapen.org/handle/20.500.12657/49264 https://directory.doabooks.org/handle/20.500.12854/70158 eng open access image/jpeg image/jpeg image/jpeg image/jpeg n/a n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/49264/1/58247.pdf https://library.oapen.org/bitstream/20.500.12657/49264/1/58247.pdf https://library.oapen.org/bitstream/20.500.12657/49264/1/58247.pdf https://library.oapen.org/bitstream/20.500.12657/49264/1/58247.pdf InTechOpen 10.5772/intechopen.72532 10.5772/intechopen.72532 035ecc65-6737-43cf-a13a-6bdf67ce01f4 H2020 Science with and for Society open access |
| spellingShingle | polarized light imaging, scientific visualization, neuroinformatics, neuroimaging and fiber architecture thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Schubert, Nicole Axer, Markus Pietrzyk, Uwe Amunts, Katrin Chapter 3D Polarized Light Imaging Portrayed: Visualization of Fiber Architecture Derived from 3D-PLI |
| title | Chapter 3D Polarized Light Imaging Portrayed: Visualization of Fiber Architecture Derived from 3D-PLI |
| title_full | Chapter 3D Polarized Light Imaging Portrayed: Visualization of Fiber Architecture Derived from 3D-PLI |
| title_fullStr | Chapter 3D Polarized Light Imaging Portrayed: Visualization of Fiber Architecture Derived from 3D-PLI |
| title_full_unstemmed | Chapter 3D Polarized Light Imaging Portrayed: Visualization of Fiber Architecture Derived from 3D-PLI |
| title_short | Chapter 3D Polarized Light Imaging Portrayed: Visualization of Fiber Architecture Derived from 3D-PLI |
| title_sort | chapter 3d polarized light imaging portrayed visualization of fiber architecture derived from 3d pli |
| topic | polarized light imaging, scientific visualization, neuroinformatics, neuroimaging and fiber architecture thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | polarized light imaging, scientific visualization, neuroinformatics, neuroimaging and fiber architecture thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20210602_10.5772/intechopen.72532_378 |
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