Chapter Membrane Dynamics of Spermatozoa during Capacitation: New Insight in Germ Cells Signalling
The study of germline stem cells and of germline cells has deep implications for the understanding of fertility, development and cancer. Nowadays, we are experiencing the very fascinating challenge of application of –OMICS technologies to this issue, which is opening new and unexpected horizons in v...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
InTechOpen
2021
|
| Subjects: | |
| Online Access: | ONIX_20210602_10.5772/intechopen.69964_367 |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1869526201963380736 |
|---|---|
| author | Ramal Sanchez, Marina Mattioli, Mauro Valbonetti, Luca Barboni, Barbara Bernabò, Nicola Capacchietti, Giulia |
| author_browse | Barboni, Barbara Bernabò, Nicola Capacchietti, Giulia Mattioli, Mauro Ramal Sanchez, Marina Valbonetti, Luca |
| author_facet | Ramal Sanchez, Marina Mattioli, Mauro Valbonetti, Luca Barboni, Barbara Bernabò, Nicola Capacchietti, Giulia |
| author_sort | Ramal Sanchez, Marina |
| collection | Directory of Open Access Books |
| description | The study of germline stem cells and of germline cells has deep implications for the understanding of fertility, development and cancer. Nowadays, we are experiencing the very fascinating challenge of application of –OMICS technologies to this issue, which is opening new and unexpected horizons in virtually all the branches of biology. Here, we carried out a review of signalling systems involved in maturation of male germ cells and in the process that leads them to become fully fertile. In particular, we discuss the control mechanisms involved in capacitation and acrosome reaction that act at membrane level. Indeed, spermatozoa membranes play key roles in determining the achievement of fertility: they are the interface with the surrounding environment, they locate the signal transduction systems and they are active in recognizing and binding the oocyte. In addition, we discuss the effect of several compounds that could exert a negative effect on reproductive activity, by interfering with the endocrine axis, the so-called endocrine disruptors. |
| format | Online |
| id | doab-20.500.12854ir-70238 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-702382025-08-13T14:11:47Z Chapter Membrane Dynamics of Spermatozoa during Capacitation: New Insight in Germ Cells Signalling Ramal Sanchez, Marina Mattioli, Mauro Valbonetti, Luca Barboni, Barbara Bernabò, Nicola Capacchietti, Giulia germline stem cells, spermatozoa, membrane, signalling, fertility thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFK Human reproduction, growth and development::MFKC Reproductive medicine thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFK Human reproduction, growth and development::MFKC Reproductive medicine The study of germline stem cells and of germline cells has deep implications for the understanding of fertility, development and cancer. Nowadays, we are experiencing the very fascinating challenge of application of –OMICS technologies to this issue, which is opening new and unexpected horizons in virtually all the branches of biology. Here, we carried out a review of signalling systems involved in maturation of male germ cells and in the process that leads them to become fully fertile. In particular, we discuss the control mechanisms involved in capacitation and acrosome reaction that act at membrane level. Indeed, spermatozoa membranes play key roles in determining the achievement of fertility: they are the interface with the surrounding environment, they locate the signal transduction systems and they are active in recognizing and binding the oocyte. In addition, we discuss the effect of several compounds that could exert a negative effect on reproductive activity, by interfering with the endocrine axis, the so-called endocrine disruptors. 2021-02-10T12:58:18Z 2021-06-02T10:10:38Z 2018 chapter ONIX_20210602_10.5772/intechopen.69964_367 https://library.oapen.org/handle/20.500.12657/49253 https://directory.doabooks.org/handle/20.500.12854/70238 eng open access image/jpeg image/jpeg image/jpeg n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/49253/1/56417.pdf https://library.oapen.org/bitstream/20.500.12657/49253/1/56417.pdf https://library.oapen.org/bitstream/20.500.12657/49253/1/56417.pdf InTechOpen 10.5772/intechopen.69964 10.5772/intechopen.69964 035ecc65-6737-43cf-a13a-6bdf67ce01f4 open access |
| spellingShingle | germline stem cells, spermatozoa, membrane, signalling, fertility thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFK Human reproduction, growth and development::MFKC Reproductive medicine thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFK Human reproduction, growth and development::MFKC Reproductive medicine Ramal Sanchez, Marina Mattioli, Mauro Valbonetti, Luca Barboni, Barbara Bernabò, Nicola Capacchietti, Giulia Chapter Membrane Dynamics of Spermatozoa during Capacitation: New Insight in Germ Cells Signalling |
| title | Chapter Membrane Dynamics of Spermatozoa during Capacitation: New Insight in Germ Cells Signalling |
| title_full | Chapter Membrane Dynamics of Spermatozoa during Capacitation: New Insight in Germ Cells Signalling |
| title_fullStr | Chapter Membrane Dynamics of Spermatozoa during Capacitation: New Insight in Germ Cells Signalling |
| title_full_unstemmed | Chapter Membrane Dynamics of Spermatozoa during Capacitation: New Insight in Germ Cells Signalling |
| title_short | Chapter Membrane Dynamics of Spermatozoa during Capacitation: New Insight in Germ Cells Signalling |
| title_sort | chapter membrane dynamics of spermatozoa during capacitation new insight in germ cells signalling |
| topic | germline stem cells, spermatozoa, membrane, signalling, fertility thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFK Human reproduction, growth and development::MFKC Reproductive medicine thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFK Human reproduction, growth and development::MFKC Reproductive medicine |
| topic_facet | germline stem cells, spermatozoa, membrane, signalling, fertility thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFK Human reproduction, growth and development::MFKC Reproductive medicine thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFK Human reproduction, growth and development::MFKC Reproductive medicine |
| url | ONIX_20210602_10.5772/intechopen.69964_367 |
| work_keys_str_mv | AT ramalsanchezmarina chaptermembranedynamicsofspermatozoaduringcapacitationnewinsightingermcellssignalling AT mattiolimauro chaptermembranedynamicsofspermatozoaduringcapacitationnewinsightingermcellssignalling AT valbonettiluca chaptermembranedynamicsofspermatozoaduringcapacitationnewinsightingermcellssignalling AT barbonibarbara chaptermembranedynamicsofspermatozoaduringcapacitationnewinsightingermcellssignalling AT bernabonicola chaptermembranedynamicsofspermatozoaduringcapacitationnewinsightingermcellssignalling AT capacchiettigiulia chaptermembranedynamicsofspermatozoaduringcapacitationnewinsightingermcellssignalling |