Chapter The Cross Talk among Autophagy, Ubiquitination, and DNA Repair: An Overview
Cellular plasticity is modulated by protein posttranslational modifications, which act on most intracellular pathways. Ubiquitination is a versatile posttranslational modification (PTM) that influences protein fate, controlling their degradation or modulating their activity and subcellular localizat...
সংরক্ষণ করুন:
| প্রধান লেখক: | , , |
|---|---|
| বিন্যাস: | Online |
| ভাষা: | ইংরেজি |
| প্রকাশিত: |
InTechOpen
2021
|
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | ONIX_20210602_10.5772/intechopen.71404_350 |
| ট্যাগগুলো: |
কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!
|
| _version_ | 1869525859159769088 |
|---|---|
| author | Nazio, Francesca Cecconi, Francesco Maiani, Emiliano |
| author_browse | Cecconi, Francesco Maiani, Emiliano Nazio, Francesca |
| author_facet | Nazio, Francesca Cecconi, Francesco Maiani, Emiliano |
| author_sort | Nazio, Francesca |
| collection | Directory of Open Access Books |
| description | Cellular plasticity is modulated by protein posttranslational modifications, which act on most intracellular pathways. Ubiquitination is a versatile posttranslational modification (PTM) that influences protein fate, controlling their degradation or modulating their activity and subcellular localization. The ubiquitin proteasome system, UPS, and the autophagic pathway are the main degradative intracellular machineries, which rely on ubiquitination for their activation and/or the selective recycling of proteins and organelles. Recent findings indicate that the cross talk between UPS and autophagy plays a key role in controlling DNA repair pathways. Even being a cytoplasmic process, it is now clear that autophagy can directly impact on the correct activation of DNA repair. Of note, defects on autophagy are related to the impairment of homologous recombination repair and to an increase of the nonhomologous end joining repair activity. These evidences give new insights into the molecular processes underlying the DNA damage response and provide further explanation for the tumorigenesis associated with autophagy impairment. Moreover, these findings introduce new examples of synthetic lethality between autophagy and DNA repair genes and lead to the possible development of target therapies for tumors with defective autophagy. |
| format | Online |
| id | doab-20.500.12854ir-70294 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-702942025-08-13T14:11:53Z Chapter The Cross Talk among Autophagy, Ubiquitination, and DNA Repair: An Overview Nazio, Francesca Cecconi, Francesco Maiani, Emiliano autophagy, DNA repair, ubiquitination, ubiquitin proteasome system, p62 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Cellular plasticity is modulated by protein posttranslational modifications, which act on most intracellular pathways. Ubiquitination is a versatile posttranslational modification (PTM) that influences protein fate, controlling their degradation or modulating their activity and subcellular localization. The ubiquitin proteasome system, UPS, and the autophagic pathway are the main degradative intracellular machineries, which rely on ubiquitination for their activation and/or the selective recycling of proteins and organelles. Recent findings indicate that the cross talk between UPS and autophagy plays a key role in controlling DNA repair pathways. Even being a cytoplasmic process, it is now clear that autophagy can directly impact on the correct activation of DNA repair. Of note, defects on autophagy are related to the impairment of homologous recombination repair and to an increase of the nonhomologous end joining repair activity. These evidences give new insights into the molecular processes underlying the DNA damage response and provide further explanation for the tumorigenesis associated with autophagy impairment. Moreover, these findings introduce new examples of synthetic lethality between autophagy and DNA repair genes and lead to the possible development of target therapies for tumors with defective autophagy. 2021-02-10T12:58:18Z 2021-06-02T10:10:12Z 2018 chapter ONIX_20210602_10.5772/intechopen.71404_350 https://library.oapen.org/handle/20.500.12657/49236 https://directory.doabooks.org/handle/20.500.12854/70294 eng open access image/jpeg image/jpeg image/jpeg n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/49236/1/57410.pdf https://library.oapen.org/bitstream/20.500.12657/49236/1/57410.pdf https://library.oapen.org/bitstream/20.500.12657/49236/1/57410.pdf InTechOpen 10.5772/intechopen.71404 10.5772/intechopen.71404 035ecc65-6737-43cf-a13a-6bdf67ce01f4 open access |
| spellingShingle | autophagy, DNA repair, ubiquitination, ubiquitin proteasome system, p62 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Nazio, Francesca Cecconi, Francesco Maiani, Emiliano Chapter The Cross Talk among Autophagy, Ubiquitination, and DNA Repair: An Overview |
| title | Chapter The Cross Talk among Autophagy, Ubiquitination, and DNA Repair: An Overview |
| title_full | Chapter The Cross Talk among Autophagy, Ubiquitination, and DNA Repair: An Overview |
| title_fullStr | Chapter The Cross Talk among Autophagy, Ubiquitination, and DNA Repair: An Overview |
| title_full_unstemmed | Chapter The Cross Talk among Autophagy, Ubiquitination, and DNA Repair: An Overview |
| title_short | Chapter The Cross Talk among Autophagy, Ubiquitination, and DNA Repair: An Overview |
| title_sort | chapter the cross talk among autophagy ubiquitination and dna repair an overview |
| topic | autophagy, DNA repair, ubiquitination, ubiquitin proteasome system, p62 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | autophagy, DNA repair, ubiquitination, ubiquitin proteasome system, p62 thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | ONIX_20210602_10.5772/intechopen.71404_350 |
| work_keys_str_mv | AT naziofrancesca chapterthecrosstalkamongautophagyubiquitinationanddnarepairanoverview AT cecconifrancesco chapterthecrosstalkamongautophagyubiquitinationanddnarepairanoverview AT maianiemiliano chapterthecrosstalkamongautophagyubiquitinationanddnarepairanoverview |