Chapter The Zebrafish Kupffer’s Vesicle: A Special Organ in a Model Organism to Study Human Diseases
The Kupffer’s vesicle (KV) is a small, ciliated organ transiently present during embryogenesis of the zebrafish and other teleosts. The KV is required to the establishment of visceral laterality, such as the heart on the left side, being also known by the name left-right organizer (LRO). The LRO is...
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| Định dạng: | Online |
| Ngôn ngữ: | Tiếng Anh |
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InTechOpen
2021
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| Những chủ đề: | |
| Truy cập trực tuyến: | ONIX_20210602_10.5772/intechopen.88266_474 |
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| _version_ | 1869531142912212992 |
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| author | Roxo-Rosa, Mónica Lopes, Susana S. |
| author_browse | Lopes, Susana S. Roxo-Rosa, Mónica |
| author_facet | Roxo-Rosa, Mónica Lopes, Susana S. |
| author_sort | Roxo-Rosa, Mónica |
| collection | Directory of Open Access Books |
| description | The Kupffer’s vesicle (KV) is a small, ciliated organ transiently present during embryogenesis of the zebrafish and other teleosts. The KV is required to the establishment of visceral laterality, such as the heart on the left side, being also known by the name left-right organizer (LRO). The LRO is found in other vertebrates, including mice, rabbits, frogs and human embryos. Among these, the KV became an excellent model organ to investigate the early left-right events during development and in disease. Many ciliary molecular players associated to the human disease primary ciliary dyskinesia have been tested in the zebrafish looking at KV cilia and its downstream effects on flow and left-right markers. Additionally, given its morphology and molecular features, we proposed the KV as a model organ to study the molecular mechanisms of the renal cyst inflation that occurs in the autosomal dominant polycystic kidney disease. Although having no connection to the kidney, the KV mimics a renal cyst because it is a fluid-filled vesicle, lined by monociliated epithelial cells that express polycystin-2, which knockdown leads to the organ luminal enlargement through changes in ion/water epithelial transport. Here, we explore the usefulness of the zebrafish KV to model these diseases. |
| format | Online |
| id | doab-20.500.12854ir-70308 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-703082025-08-13T14:11:54Z Chapter The Zebrafish Kupffer’s Vesicle: A Special Organ in a Model Organism to Study Human Diseases Roxo-Rosa, Mónica Lopes, Susana S. Kupffer’s vesicle (KV), left-right (LR), left-right organizer (LRO), primary ciliary dyskinesia (PCD), autosomal dominant polycystic kidney disease (ADPKD) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry The Kupffer’s vesicle (KV) is a small, ciliated organ transiently present during embryogenesis of the zebrafish and other teleosts. The KV is required to the establishment of visceral laterality, such as the heart on the left side, being also known by the name left-right organizer (LRO). The LRO is found in other vertebrates, including mice, rabbits, frogs and human embryos. Among these, the KV became an excellent model organ to investigate the early left-right events during development and in disease. Many ciliary molecular players associated to the human disease primary ciliary dyskinesia have been tested in the zebrafish looking at KV cilia and its downstream effects on flow and left-right markers. Additionally, given its morphology and molecular features, we proposed the KV as a model organ to study the molecular mechanisms of the renal cyst inflation that occurs in the autosomal dominant polycystic kidney disease. Although having no connection to the kidney, the KV mimics a renal cyst because it is a fluid-filled vesicle, lined by monociliated epithelial cells that express polycystin-2, which knockdown leads to the organ luminal enlargement through changes in ion/water epithelial transport. Here, we explore the usefulness of the zebrafish KV to model these diseases. 2021-06-02T10:13:13Z 2020 chapter ONIX_20210602_10.5772/intechopen.88266_474 https://library.oapen.org/handle/20.500.12657/49360 https://directory.doabooks.org/handle/20.500.12854/70308 eng open access image/jpeg image/jpeg image/jpeg n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/49360/1/68433.pdf https://library.oapen.org/bitstream/20.500.12657/49360/1/68433.pdf https://library.oapen.org/bitstream/20.500.12657/49360/1/68433.pdf InTechOpen 10.5772/intechopen.88266 10.5772/intechopen.88266 035ecc65-6737-43cf-a13a-6bdf67ce01f4 open access |
| spellingShingle | Kupffer’s vesicle (KV), left-right (LR), left-right organizer (LRO), primary ciliary dyskinesia (PCD), autosomal dominant polycystic kidney disease (ADPKD) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Roxo-Rosa, Mónica Lopes, Susana S. Chapter The Zebrafish Kupffer’s Vesicle: A Special Organ in a Model Organism to Study Human Diseases |
| title | Chapter The Zebrafish Kupffer’s Vesicle: A Special Organ in a Model Organism to Study Human Diseases |
| title_full | Chapter The Zebrafish Kupffer’s Vesicle: A Special Organ in a Model Organism to Study Human Diseases |
| title_fullStr | Chapter The Zebrafish Kupffer’s Vesicle: A Special Organ in a Model Organism to Study Human Diseases |
| title_full_unstemmed | Chapter The Zebrafish Kupffer’s Vesicle: A Special Organ in a Model Organism to Study Human Diseases |
| title_short | Chapter The Zebrafish Kupffer’s Vesicle: A Special Organ in a Model Organism to Study Human Diseases |
| title_sort | chapter the zebrafish kupffer s vesicle a special organ in a model organism to study human diseases |
| topic | Kupffer’s vesicle (KV), left-right (LR), left-right organizer (LRO), primary ciliary dyskinesia (PCD), autosomal dominant polycystic kidney disease (ADPKD) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | Kupffer’s vesicle (KV), left-right (LR), left-right organizer (LRO), primary ciliary dyskinesia (PCD), autosomal dominant polycystic kidney disease (ADPKD) thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | ONIX_20210602_10.5772/intechopen.88266_474 |
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