Chapter Nitric Oxide: Key Features in Spermatozoa
Several in vitro studies have pointed to the importance of nitric oxide (NO) in the female and male reproductive system in mammals. Its functions vary from preventing oocyte aging, improving the integrity of the microtubular spindle apparatus in aged oocytes, modulating the contraction of the oviduc...
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| Format: | Online |
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InTechOpen
2021
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| Dostęp online: | ONIX_20210602_10.5772/67551_320 |
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| _version_ | 1869518715138080768 |
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| author | Staicu, Florentin-Daniel Matas Parra, Carmen |
| author_browse | Matas Parra, Carmen Staicu, Florentin-Daniel |
| author_facet | Staicu, Florentin-Daniel Matas Parra, Carmen |
| author_sort | Staicu, Florentin-Daniel |
| collection | Directory of Open Access Books |
| description | Several in vitro studies have pointed to the importance of nitric oxide (NO) in the female and male reproductive system in mammals. Its functions vary from preventing oocyte aging, improving the integrity of the microtubular spindle apparatus in aged oocytes, modulating the contraction of the oviduct, to regulating sperm physiology by affecting the motility, inducing chemotaxis in spermatozoa, regulating tyrosine phosphorylation, enhancing the sperm-zona pellucida binding ability, and modulating the acrosomal reaction. In spermatozoa, NO exerts its functions in different ways, which involve key elements such as the soluble isoform of guanylate cyclase, cyclic guanosine monophosphate (cGMP), cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), adenylate cyclase, and the extracellular signal-regulated kinase (ERK) pathway. Furthermore, NO leads to the S-nitrosylation of several sperm proteins, among them a substantial group associated with energy generation and cell movement, but also with signal transduction, suggesting a role for S-nitrosylation in sperm motility and in modulating the sperm function, respectively. In this chapter, an overview of how NO modulates the sperm physiology is presented, based on the knowledge acquired to this day. |
| format | Online |
| id | doab-20.500.12854ir-70465 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-704652024-04-05T17:30:43Z Chapter Nitric Oxide: Key Features in Spermatozoa Staicu, Florentin-Daniel Matas Parra, Carmen nitric oxide, nitric oxide synthase, S-nitrosylation, spermatozoa, fertilization thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Several in vitro studies have pointed to the importance of nitric oxide (NO) in the female and male reproductive system in mammals. Its functions vary from preventing oocyte aging, improving the integrity of the microtubular spindle apparatus in aged oocytes, modulating the contraction of the oviduct, to regulating sperm physiology by affecting the motility, inducing chemotaxis in spermatozoa, regulating tyrosine phosphorylation, enhancing the sperm-zona pellucida binding ability, and modulating the acrosomal reaction. In spermatozoa, NO exerts its functions in different ways, which involve key elements such as the soluble isoform of guanylate cyclase, cyclic guanosine monophosphate (cGMP), cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), adenylate cyclase, and the extracellular signal-regulated kinase (ERK) pathway. Furthermore, NO leads to the S-nitrosylation of several sperm proteins, among them a substantial group associated with energy generation and cell movement, but also with signal transduction, suggesting a role for S-nitrosylation in sperm motility and in modulating the sperm function, respectively. In this chapter, an overview of how NO modulates the sperm physiology is presented, based on the knowledge acquired to this day. 2021-02-10T12:58:18Z 2021-06-02T10:09:25Z 2017 chapter ONIX_20210602_10.5772/67551_320 https://library.oapen.org/handle/20.500.12657/49206 https://directory.doabooks.org/handle/20.500.12854/70465 eng open access image/jpeg image/jpeg n/a n/a https://library.oapen.org/bitstream/20.500.12657/49206/1/54171.pdf https://library.oapen.org/bitstream/20.500.12657/49206/1/54171.pdf InTechOpen 10.5772/67551 10.5772/67551 035ecc65-6737-43cf-a13a-6bdf67ce01f4 open access |
| spellingShingle | nitric oxide, nitric oxide synthase, S-nitrosylation, spermatozoa, fertilization thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Staicu, Florentin-Daniel Matas Parra, Carmen Chapter Nitric Oxide: Key Features in Spermatozoa |
| title | Chapter Nitric Oxide: Key Features in Spermatozoa |
| title_full | Chapter Nitric Oxide: Key Features in Spermatozoa |
| title_fullStr | Chapter Nitric Oxide: Key Features in Spermatozoa |
| title_full_unstemmed | Chapter Nitric Oxide: Key Features in Spermatozoa |
| title_short | Chapter Nitric Oxide: Key Features in Spermatozoa |
| title_sort | chapter nitric oxide key features in spermatozoa |
| topic | nitric oxide, nitric oxide synthase, S-nitrosylation, spermatozoa, fertilization thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | nitric oxide, nitric oxide synthase, S-nitrosylation, spermatozoa, fertilization thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | ONIX_20210602_10.5772/67551_320 |
| work_keys_str_mv | AT staicuflorentindaniel chapternitricoxidekeyfeaturesinspermatozoa AT matasparracarmen chapternitricoxidekeyfeaturesinspermatozoa |