Chapter Irreversible electroporation in pancreatic cancer
Pancreatic cancer is the deadliest of the gastrointestinal tract with 5-year survival rates of less than 5%. Given common asymptomatic early disease course, most patients (50%) present with an already metastatic disease, while only 20% can undergo potentially curative resection. The remaining 30% pr...
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InTechOpen
2021
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| Online Erişim: | ONIX_20210602_10.5772/intechopen.75737_373 |
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| _version_ | 1869515346914836480 |
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| author | Holzgang, Melanie Eigl, Benjamin Erdem, Suna Gloor, Beat Worni, Mathias |
| author_browse | Eigl, Benjamin Erdem, Suna Gloor, Beat Holzgang, Melanie Worni, Mathias |
| author_facet | Holzgang, Melanie Eigl, Benjamin Erdem, Suna Gloor, Beat Worni, Mathias |
| author_sort | Holzgang, Melanie |
| collection | Directory of Open Access Books |
| description | Pancreatic cancer is the deadliest of the gastrointestinal tract with 5-year survival rates of less than 5%. Given common asymptomatic early disease course, most patients (50%) present with an already metastatic disease, while only 20% can undergo potentially curative resection. The remaining 30% present with locally advanced disease, defined as extended vascular encasement, where the risk of surgical therapy often outweighs its benefits. Traditional thermal local ablative modalities (RFA, MWA, or cryotherapy) have the disadvantage that they are not applicable in proximity to vital vascular structures, which are abundant in the peripancreatic region. Irreversible electroporation (IRE) is an emerging non-thermal alternative that induces apoptosis of tumor cells by the delivery of short repetitive impulses of high-voltage electric current. Given its mostly non-thermal modality, IRE is not hampered by a heat-sink effect and is applicable with little risk around vascular structures, bile and pancreatic ducts. Recent research suggests that local tumor destruction through IRE improves overall survival, progression-free survival and quality of life in patients with locally advanced pancreatic cancer. |
| format | Online |
| id | doab-20.500.12854ir-70493 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-704932025-08-13T14:11:57Z Chapter Irreversible electroporation in pancreatic cancer Holzgang, Melanie Eigl, Benjamin Erdem, Suna Gloor, Beat Worni, Mathias locally advanced pancreatic cancer, borderline resectable pancreatic cancer, irreversible electroporation, local tumor destruction, apoptosis, overall survival thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues Pancreatic cancer is the deadliest of the gastrointestinal tract with 5-year survival rates of less than 5%. Given common asymptomatic early disease course, most patients (50%) present with an already metastatic disease, while only 20% can undergo potentially curative resection. The remaining 30% present with locally advanced disease, defined as extended vascular encasement, where the risk of surgical therapy often outweighs its benefits. Traditional thermal local ablative modalities (RFA, MWA, or cryotherapy) have the disadvantage that they are not applicable in proximity to vital vascular structures, which are abundant in the peripancreatic region. Irreversible electroporation (IRE) is an emerging non-thermal alternative that induces apoptosis of tumor cells by the delivery of short repetitive impulses of high-voltage electric current. Given its mostly non-thermal modality, IRE is not hampered by a heat-sink effect and is applicable with little risk around vascular structures, bile and pancreatic ducts. Recent research suggests that local tumor destruction through IRE improves overall survival, progression-free survival and quality of life in patients with locally advanced pancreatic cancer. 2021-02-10T12:58:18Z 2021-06-02T10:10:46Z 2018 chapter ONIX_20210602_10.5772/intechopen.75737_373 https://library.oapen.org/handle/20.500.12657/49259 https://directory.doabooks.org/handle/20.500.12854/70493 eng open access image/jpeg image/jpeg image/jpeg image/jpeg n/a n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/49259/1/60217.pdf https://library.oapen.org/bitstream/20.500.12657/49259/1/60217.pdf https://library.oapen.org/bitstream/20.500.12657/49259/1/60217.pdf https://library.oapen.org/bitstream/20.500.12657/49259/1/60217.pdf InTechOpen 10.5772/intechopen.75737 10.5772/intechopen.75737 035ecc65-6737-43cf-a13a-6bdf67ce01f4 open access |
| spellingShingle | locally advanced pancreatic cancer, borderline resectable pancreatic cancer, irreversible electroporation, local tumor destruction, apoptosis, overall survival thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues Holzgang, Melanie Eigl, Benjamin Erdem, Suna Gloor, Beat Worni, Mathias Chapter Irreversible electroporation in pancreatic cancer |
| title | Chapter Irreversible electroporation in pancreatic cancer |
| title_full | Chapter Irreversible electroporation in pancreatic cancer |
| title_fullStr | Chapter Irreversible electroporation in pancreatic cancer |
| title_full_unstemmed | Chapter Irreversible electroporation in pancreatic cancer |
| title_short | Chapter Irreversible electroporation in pancreatic cancer |
| title_sort | chapter irreversible electroporation in pancreatic cancer |
| topic | locally advanced pancreatic cancer, borderline resectable pancreatic cancer, irreversible electroporation, local tumor destruction, apoptosis, overall survival thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues |
| topic_facet | locally advanced pancreatic cancer, borderline resectable pancreatic cancer, irreversible electroporation, local tumor destruction, apoptosis, overall survival thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues |
| url | ONIX_20210602_10.5772/intechopen.75737_373 |
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