Chapter Hyaluronic-Based Antibacterial Hydrogel Coating for Implantable Biomaterials in Orthopedics and Trauma: From Basic Research to Clinical Applications
Bacterial colonization of implanted biomaterials remains one of the most challenging complications in orthopedics and trauma surgery, with extremely high social and economic costs. Antibacterial coating of implants has been advocated by many experts as a possible solution to reduce the burden of imp...
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| フォーマット: | Online |
| 言語: | 英語 |
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InTechOpen
2021
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| オンライン･アクセス: | ONIX_20210602_10.5772/intechopen.73203_357 |
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| author | Gaetano, Giammona Giuseppe, Pitarresi Salvatore, Palumbo Fabio Susanna, Maraldi Sara, Scarponi Luca, Romanò Carlo |
| author_browse | Gaetano, Giammona Giuseppe, Pitarresi Luca, Romanò Carlo Salvatore, Palumbo Fabio Sara, Scarponi Susanna, Maraldi |
| author_facet | Gaetano, Giammona Giuseppe, Pitarresi Salvatore, Palumbo Fabio Susanna, Maraldi Sara, Scarponi Luca, Romanò Carlo |
| author_sort | Gaetano, Giammona |
| collection | Directory of Open Access Books |
| description | Bacterial colonization of implanted biomaterials remains one of the most challenging complications in orthopedics and trauma surgery, with extremely high social and economic costs. Antibacterial coating of implants has been advocated by many experts as a possible solution to reduce the burden of implant-related infection and several different solutions have been proposed in the last decades. However, while most of the investigated technologies have shown their efficacy in vitro and/or in vivo, only few were able to reach the market, due to clinical, industrial, economic and regulatory issues. Hyaluronic acid composites have been previously shown to possess antifouling capabilities and have been used in various clinical settings to reduce bacterial adhesion and mitigate biofilm-related infections. Recently, a fast-resorbable, hyaluronic-based hydrogel coating was developed to protect implanted biomaterials in orthopedics, trauma and maxillofacial surgery. Preclinical and clinical testing did show the safety and efficacy of the device that can be intraoperatively loaded with one or more antibiotics and directly applied by the surgeon to the implant surface, at the time of surgery. Here, we review the current evidence concerning this very first antibacterial coating of implants and outline the economic impact of the possible large-scale application of this technology. |
| format | Online |
| id | doab-20.500.12854ir-70503 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-705032025-08-13T14:11:58Z Chapter Hyaluronic-Based Antibacterial Hydrogel Coating for Implantable Biomaterials in Orthopedics and Trauma: From Basic Research to Clinical Applications Gaetano, Giammona Giuseppe, Pitarresi Salvatore, Palumbo Fabio Susanna, Maraldi Sara, Scarponi Luca, Romanò Carlo coating, hydrogel, hyaluronic acid, DAC, infection, implant, orthopedic, trauma, prosthesis, prevention thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry::PNNP Polymer chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry::PNNP Polymer chemistry Bacterial colonization of implanted biomaterials remains one of the most challenging complications in orthopedics and trauma surgery, with extremely high social and economic costs. Antibacterial coating of implants has been advocated by many experts as a possible solution to reduce the burden of implant-related infection and several different solutions have been proposed in the last decades. However, while most of the investigated technologies have shown their efficacy in vitro and/or in vivo, only few were able to reach the market, due to clinical, industrial, economic and regulatory issues. Hyaluronic acid composites have been previously shown to possess antifouling capabilities and have been used in various clinical settings to reduce bacterial adhesion and mitigate biofilm-related infections. Recently, a fast-resorbable, hyaluronic-based hydrogel coating was developed to protect implanted biomaterials in orthopedics, trauma and maxillofacial surgery. Preclinical and clinical testing did show the safety and efficacy of the device that can be intraoperatively loaded with one or more antibiotics and directly applied by the surgeon to the implant surface, at the time of surgery. Here, we review the current evidence concerning this very first antibacterial coating of implants and outline the economic impact of the possible large-scale application of this technology. 2021-02-10T12:58:18Z 2021-06-02T10:10:23Z 2018 chapter ONIX_20210602_10.5772/intechopen.73203_357 https://library.oapen.org/handle/20.500.12657/49243 https://directory.doabooks.org/handle/20.500.12854/70503 eng open access image/jpeg image/jpeg image/jpeg image/jpeg n/a n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/49243/1/58973.pdf https://library.oapen.org/bitstream/20.500.12657/49243/1/58973.pdf https://library.oapen.org/bitstream/20.500.12657/49243/1/58973.pdf https://library.oapen.org/bitstream/20.500.12657/49243/1/58973.pdf InTechOpen 10.5772/intechopen.73203 10.5772/intechopen.73203 035ecc65-6737-43cf-a13a-6bdf67ce01f4 open access |
| spellingShingle | coating, hydrogel, hyaluronic acid, DAC, infection, implant, orthopedic, trauma, prosthesis, prevention thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry::PNNP Polymer chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry::PNNP Polymer chemistry Gaetano, Giammona Giuseppe, Pitarresi Salvatore, Palumbo Fabio Susanna, Maraldi Sara, Scarponi Luca, Romanò Carlo Chapter Hyaluronic-Based Antibacterial Hydrogel Coating for Implantable Biomaterials in Orthopedics and Trauma: From Basic Research to Clinical Applications |
| title | Chapter Hyaluronic-Based Antibacterial Hydrogel Coating for Implantable Biomaterials in Orthopedics and Trauma: From Basic Research to Clinical Applications |
| title_full | Chapter Hyaluronic-Based Antibacterial Hydrogel Coating for Implantable Biomaterials in Orthopedics and Trauma: From Basic Research to Clinical Applications |
| title_fullStr | Chapter Hyaluronic-Based Antibacterial Hydrogel Coating for Implantable Biomaterials in Orthopedics and Trauma: From Basic Research to Clinical Applications |
| title_full_unstemmed | Chapter Hyaluronic-Based Antibacterial Hydrogel Coating for Implantable Biomaterials in Orthopedics and Trauma: From Basic Research to Clinical Applications |
| title_short | Chapter Hyaluronic-Based Antibacterial Hydrogel Coating for Implantable Biomaterials in Orthopedics and Trauma: From Basic Research to Clinical Applications |
| title_sort | chapter hyaluronic based antibacterial hydrogel coating for implantable biomaterials in orthopedics and trauma from basic research to clinical applications |
| topic | coating, hydrogel, hyaluronic acid, DAC, infection, implant, orthopedic, trauma, prosthesis, prevention thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry::PNNP Polymer chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry::PNNP Polymer chemistry |
| topic_facet | coating, hydrogel, hyaluronic acid, DAC, infection, implant, orthopedic, trauma, prosthesis, prevention thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry::PNNP Polymer chemistry thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry::PNNP Polymer chemistry |
| url | ONIX_20210602_10.5772/intechopen.73203_357 |
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