Chapter Challenges and New Frontiers in the Paediatric Drug Discovery and Development
Drug discovery and development advances in the last decades allowed to find a treatment for many preventable diseases. However, all too often, children are excluded from these progresses since most of the new medicines have been discovered and developed for the adult population. Even if paediatricia...
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| Format: | Online |
| Sprache: | Englisch |
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2021
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| Online-Zugang: | ONIX_20210602_10.5772/intechopen.85635_469 |
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| author | Bonifazi, Donato Migliaccio, Giovanni Intini, Angelica |
| author_browse | Bonifazi, Donato Intini, Angelica Migliaccio, Giovanni |
| author_facet | Bonifazi, Donato Migliaccio, Giovanni Intini, Angelica |
| author_sort | Bonifazi, Donato |
| collection | Directory of Open Access Books |
| description | Drug discovery and development advances in the last decades allowed to find a treatment for many preventable diseases. However, all too often, children are excluded from these progresses since most of the new medicines have been discovered and developed for the adult population. Even if paediatricians routinely give drugs to children ‘off-label’, researchers have demonstrated that children do not respond to medications in the same way as adults. Furthermore, certain specific disorders are unique to children or occur in children differently than in adults. Besides specifically testing medicines in children in proper clinical studies taking into due account the peculiarity of this population, there is a growing recognition of the need to develop paediatric medicines having in mind the specificities of this vulnerable population. In this chapter, we will provide an overview on the drug discovery and development path for children highlighting challenges and new frontiers of each phase from the discovery to the preclinical and clinical development as well as we will provide a slightest hint about paediatric biomarkers discovery, age-appropriate formulation, pregnancy, and perinatal pharmacology and in silico pharmacology. Finally, pricing and reimbursement policies for medicines and new and existing research initiatives in the field will be discussed. |
| format | Online |
| id | doab-20.500.12854ir-70534 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-705342025-08-13T14:11:59Z Chapter Challenges and New Frontiers in the Paediatric Drug Discovery and Development Bonifazi, Donato Migliaccio, Giovanni Intini, Angelica human development research, paediatric drug discovery, preclinical research, juvenile animal models, paediatric pharmacology, paediatric biomarkers, age-appropriate formulations, perinatal pharmacology, physiologically-based pharmacokinetic (PBPK) thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Drug discovery and development advances in the last decades allowed to find a treatment for many preventable diseases. However, all too often, children are excluded from these progresses since most of the new medicines have been discovered and developed for the adult population. Even if paediatricians routinely give drugs to children ‘off-label’, researchers have demonstrated that children do not respond to medications in the same way as adults. Furthermore, certain specific disorders are unique to children or occur in children differently than in adults. Besides specifically testing medicines in children in proper clinical studies taking into due account the peculiarity of this population, there is a growing recognition of the need to develop paediatric medicines having in mind the specificities of this vulnerable population. In this chapter, we will provide an overview on the drug discovery and development path for children highlighting challenges and new frontiers of each phase from the discovery to the preclinical and clinical development as well as we will provide a slightest hint about paediatric biomarkers discovery, age-appropriate formulation, pregnancy, and perinatal pharmacology and in silico pharmacology. Finally, pricing and reimbursement policies for medicines and new and existing research initiatives in the field will be discussed. 2021-06-02T10:13:06Z 2020 chapter ONIX_20210602_10.5772/intechopen.85635_469 https://library.oapen.org/handle/20.500.12657/49355 https://directory.doabooks.org/handle/20.500.12854/70534 eng open access image/jpeg image/jpeg image/jpeg n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/49355/1/66531.pdf https://library.oapen.org/bitstream/20.500.12657/49355/1/66531.pdf https://library.oapen.org/bitstream/20.500.12657/49355/1/66531.pdf InTechOpen 10.5772/intechopen.85635 10.5772/intechopen.85635 035ecc65-6737-43cf-a13a-6bdf67ce01f4 open access |
| spellingShingle | human development research, paediatric drug discovery, preclinical research, juvenile animal models, paediatric pharmacology, paediatric biomarkers, age-appropriate formulations, perinatal pharmacology, physiologically-based pharmacokinetic (PBPK) thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Bonifazi, Donato Migliaccio, Giovanni Intini, Angelica Chapter Challenges and New Frontiers in the Paediatric Drug Discovery and Development |
| title | Chapter Challenges and New Frontiers in the Paediatric Drug Discovery and Development |
| title_full | Chapter Challenges and New Frontiers in the Paediatric Drug Discovery and Development |
| title_fullStr | Chapter Challenges and New Frontiers in the Paediatric Drug Discovery and Development |
| title_full_unstemmed | Chapter Challenges and New Frontiers in the Paediatric Drug Discovery and Development |
| title_short | Chapter Challenges and New Frontiers in the Paediatric Drug Discovery and Development |
| title_sort | chapter challenges and new frontiers in the paediatric drug discovery and development |
| topic | human development research, paediatric drug discovery, preclinical research, juvenile animal models, paediatric pharmacology, paediatric biomarkers, age-appropriate formulations, perinatal pharmacology, physiologically-based pharmacokinetic (PBPK) thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | human development research, paediatric drug discovery, preclinical research, juvenile animal models, paediatric pharmacology, paediatric biomarkers, age-appropriate formulations, perinatal pharmacology, physiologically-based pharmacokinetic (PBPK) thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20210602_10.5772/intechopen.85635_469 |
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