Chapter Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits
The repair of peripheral nerve traumatic lesions still represents a major cause of permanent motor and sensory impairment. In case of substance loss, a nerve guide should be used to bridge the proximal with the distal stump of the severed nerve. The effectiveness of hollow nerve guides is limited by...
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| Главные авторы: | , , , , , , , , , , , |
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| Формат: | Online |
| Язык: | английский |
| Опубликовано: |
InTechOpen
2021
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| Предметы: | |
| Online-ссылка: | ONIX_20210602_10.5772/intechopen.69882_323 |
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| _version_ | 1869515540125450240 |
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| author | Ronchi, Giulia Shahar, Abraham Rochkind, Shimon Reider, Evgeniy Bitan, Yifat Geuna, Stefano Viano, Nicoletta Koren, Akiva Mandelbaum-Livnat, Mira M. Morano, Michela Ziv-Polat, Ofra Biron, Tali |
| author_browse | Biron, Tali Bitan, Yifat Geuna, Stefano Koren, Akiva Mandelbaum-Livnat, Mira M. Morano, Michela Reider, Evgeniy Rochkind, Shimon Ronchi, Giulia Shahar, Abraham Viano, Nicoletta Ziv-Polat, Ofra |
| author_facet | Ronchi, Giulia Shahar, Abraham Rochkind, Shimon Reider, Evgeniy Bitan, Yifat Geuna, Stefano Viano, Nicoletta Koren, Akiva Mandelbaum-Livnat, Mira M. Morano, Michela Ziv-Polat, Ofra Biron, Tali |
| author_sort | Ronchi, Giulia |
| collection | Directory of Open Access Books |
| description | The repair of peripheral nerve traumatic lesions still represents a major cause of permanent motor and sensory impairment. In case of substance loss, a nerve guide should be used to bridge the proximal with the distal stump of the severed nerve. The effectiveness of hollow nerve guides is limited by the delay of axonal growth due to the absence of a regeneration substrate inside the conduit. To fasten up nerve regeneration, nerve guides should thus be enriched by a luminal filler. In this study, we investigated, in a 12-mm rat sciatic nerve defect experimental model, the effectiveness of chitosan-based conduits of different acetylation filled either with a hyaluronic acid gel (NVR gel) or with a magnetic fibrin hydrogel, in comparison with traditional autografts. Results showed that all types of artificial nerve conduits led to functional recovery not significantly different from autografts. By contrast, morphological and morphometrical analyses showed that the best results among nerve guides were found in medium degree of acetylation (DAII: ∼5%) chitosan conduits enriched with the NVR gel. |
| format | Online |
| id | doab-20.500.12854ir-70657 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-706572024-04-01T14:12:05Z Chapter Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits Ronchi, Giulia Shahar, Abraham Rochkind, Shimon Reider, Evgeniy Bitan, Yifat Geuna, Stefano Viano, Nicoletta Koren, Akiva Mandelbaum-Livnat, Mira M. Morano, Michela Ziv-Polat, Ofra Biron, Tali peripheral nerve injury, chitosan guidance conduit, conduit acetylation, hyaluronic acid gel, magnetic fibrin hydrogel thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering The repair of peripheral nerve traumatic lesions still represents a major cause of permanent motor and sensory impairment. In case of substance loss, a nerve guide should be used to bridge the proximal with the distal stump of the severed nerve. The effectiveness of hollow nerve guides is limited by the delay of axonal growth due to the absence of a regeneration substrate inside the conduit. To fasten up nerve regeneration, nerve guides should thus be enriched by a luminal filler. In this study, we investigated, in a 12-mm rat sciatic nerve defect experimental model, the effectiveness of chitosan-based conduits of different acetylation filled either with a hyaluronic acid gel (NVR gel) or with a magnetic fibrin hydrogel, in comparison with traditional autografts. Results showed that all types of artificial nerve conduits led to functional recovery not significantly different from autografts. By contrast, morphological and morphometrical analyses showed that the best results among nerve guides were found in medium degree of acetylation (DAII: ∼5%) chitosan conduits enriched with the NVR gel. 2021-02-10T12:58:18Z 2021-06-02T10:09:29Z 2017 chapter ONIX_20210602_10.5772/intechopen.69882_323 https://library.oapen.org/handle/20.500.12657/49209 https://directory.doabooks.org/handle/20.500.12854/70657 eng open access image/jpeg image/jpeg n/a n/a https://library.oapen.org/bitstream/20.500.12657/49209/1/56172.pdf https://library.oapen.org/bitstream/20.500.12657/49209/1/56172.pdf InTechOpen 10.5772/intechopen.69882 10.5772/intechopen.69882 035ecc65-6737-43cf-a13a-6bdf67ce01f4 open access |
| spellingShingle | peripheral nerve injury, chitosan guidance conduit, conduit acetylation, hyaluronic acid gel, magnetic fibrin hydrogel thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering Ronchi, Giulia Shahar, Abraham Rochkind, Shimon Reider, Evgeniy Bitan, Yifat Geuna, Stefano Viano, Nicoletta Koren, Akiva Mandelbaum-Livnat, Mira M. Morano, Michela Ziv-Polat, Ofra Biron, Tali Chapter Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits |
| title | Chapter Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits |
| title_full | Chapter Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits |
| title_fullStr | Chapter Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits |
| title_full_unstemmed | Chapter Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits |
| title_short | Chapter Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits |
| title_sort | chapter peripheral nerve reconstruction using enriched chitosan conduits |
| topic | peripheral nerve injury, chitosan guidance conduit, conduit acetylation, hyaluronic acid gel, magnetic fibrin hydrogel thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering |
| topic_facet | peripheral nerve injury, chitosan guidance conduit, conduit acetylation, hyaluronic acid gel, magnetic fibrin hydrogel thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering |
| url | ONIX_20210602_10.5772/intechopen.69882_323 |
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