Chapter Advanced Microfluidic Assays for Caenorhabditis elegans
Gait function can be altered after incomplete spinal cord (iSCI) lesions. Muscular weakness, co‐activation of antagonist muscles, and altered muscle mechanics are likely to provoke abnormal gait and postural movements. Functional scales are available for assessment of functional walking in SCI patie...
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| Format: | Online |
| Jezik: | engleski |
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InTechOpen
2021
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| Online pristup: | ONIX_20210602_10.5772/64283_286 |
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| _version_ | 1869520059495350272 |
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| author | Bakhtina, Natalia A. MacKinnon, Neil Korvink, Jan G. |
| author_browse | Bakhtina, Natalia A. Korvink, Jan G. MacKinnon, Neil |
| author_facet | Bakhtina, Natalia A. MacKinnon, Neil Korvink, Jan G. |
| author_sort | Bakhtina, Natalia A. |
| collection | Directory of Open Access Books |
| description | Gait function can be altered after incomplete spinal cord (iSCI) lesions. Muscular weakness, co‐activation of antagonist muscles, and altered muscle mechanics are likely to provoke abnormal gait and postural movements. Functional scales are available for assessment of functional walking in SCI patients, such as walking index for spinal cord injury (WISCI II), timed up and go (TUG) test, 10‐meter walk test (10MWT), and 6‐minute walk test (6MWT). Novel metrics for a more detailed comprehension of neuromuscular control in terms of degree of voluntary motor control have been recently proposed. This section describes novel techniques based on muscle synergy and frequency domain analysis of electromyographic signals. Such techniques are illustrated as potential tools for assessment of motor function after SCI with experimental data and a case study describing a diagnostic scenario. This chapter presents a discussion of the current status of the emerging metrics for assessment of sensorimotor impairments. Conclusions are given with respect to the availability of enriched information about neuromuscular behavior between functional tasks (walking and pedalling) and the potential relevance of these new techniques to improve the efficacy of treatment to improve locomotion after iSCI. |
| format | Online |
| id | doab-20.500.12854ir-70661 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | InTechOpen |
| publisherStr | InTechOpen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-706612025-05-09T12:03:39Z Chapter Advanced Microfluidic Assays for Caenorhabditis elegans Bakhtina, Natalia A. MacKinnon, Neil Korvink, Jan G. Rehabilitation, spinal cord injury, walking, functional scales Gait function can be altered after incomplete spinal cord (iSCI) lesions. Muscular weakness, co‐activation of antagonist muscles, and altered muscle mechanics are likely to provoke abnormal gait and postural movements. Functional scales are available for assessment of functional walking in SCI patients, such as walking index for spinal cord injury (WISCI II), timed up and go (TUG) test, 10‐meter walk test (10MWT), and 6‐minute walk test (6MWT). Novel metrics for a more detailed comprehension of neuromuscular control in terms of degree of voluntary motor control have been recently proposed. This section describes novel techniques based on muscle synergy and frequency domain analysis of electromyographic signals. Such techniques are illustrated as potential tools for assessment of motor function after SCI with experimental data and a case study describing a diagnostic scenario. This chapter presents a discussion of the current status of the emerging metrics for assessment of sensorimotor impairments. Conclusions are given with respect to the availability of enriched information about neuromuscular behavior between functional tasks (walking and pedalling) and the potential relevance of these new techniques to improve the efficacy of treatment to improve locomotion after iSCI. 2021-06-03T02:11:17Z 2021-06-03T02:11:17Z 2021-06-02T10:08:22Z 2016 chapter ONIX_20210602_10.5772/64283_286 https://library.oapen.org/handle/20.500.12657/49172 https://directory.doabooks.org/handle/20.500.12854/70661 eng open access image/jpeg image/jpeg n/a n/a https://library.oapen.org/bitstream/20.500.12657/49172/1/51261.pdf https://library.oapen.org/bitstream/20.500.12657/49172/1/51261.pdf InTechOpen 10.5772/64283 10.5772/64283 035ecc65-6737-43cf-a13a-6bdf67ce01f4 FP7 Ideas: European Research Council 7292b17b-f01a-4016-94d3-d7fb5ef9fb79 European Research Council (ERC) EU collection 290586 open access |
| spellingShingle | Rehabilitation, spinal cord injury, walking, functional scales Bakhtina, Natalia A. MacKinnon, Neil Korvink, Jan G. Chapter Advanced Microfluidic Assays for Caenorhabditis elegans |
| title | Chapter Advanced Microfluidic Assays for Caenorhabditis elegans |
| title_full | Chapter Advanced Microfluidic Assays for Caenorhabditis elegans |
| title_fullStr | Chapter Advanced Microfluidic Assays for Caenorhabditis elegans |
| title_full_unstemmed | Chapter Advanced Microfluidic Assays for Caenorhabditis elegans |
| title_short | Chapter Advanced Microfluidic Assays for Caenorhabditis elegans |
| title_sort | chapter advanced microfluidic assays for caenorhabditis elegans |
| topic | Rehabilitation, spinal cord injury, walking, functional scales |
| topic_facet | Rehabilitation, spinal cord injury, walking, functional scales |
| url | ONIX_20210602_10.5772/64283_286 |
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