Development of Humanized Mouse Models for Infectious Diseases and Cancer
While the traditional animal models contributed immensely to biomedical research there remain many knowledge gaps in translating the results from these to humans. In this context, humanized mice transplanted with functional human cells in a physiological setting offer many advantages in deriving pre...
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| Формат: | Online |
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| Язык: | английский |
| Опубликовано: |
Frontiers Media SA
2021
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| Online-ссылка: | ONIX_20211118_9782889634811_767 |
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| collection | Directory of Open Access Books |
| description | While the traditional animal models contributed immensely to biomedical research there remain many knowledge gaps in translating the results from these to humans. In this context, humanized mice transplanted with functional human cells in a physiological setting offer many advantages in deriving pre-clinical data more akin to that seen in the natural human host. There have been many recent advances in the field that encompass derivation of new transgenic breeds of immunodeficient mice harboring human cytokines and HLA alleles that permit improved human cell engraftment and differentiation. The ability to generate humanized mice with a functional immune system together with human tissue transplantation such as a functional liver has now paved the way for new experimentation not previously feasible and is beginning to shed light on the complex picture of human pathophysiology and immunopathogenesis. Specifically, human specific pathogens such as HIV, hepatitis viruses and malaria parasites are being studied in these systems and important data on pathogen life cycles in human cells in vivo, viral latency and human specific immune responses are being gathered. In the hematology front, new data are emerging on graft versus host disease using these models. Patient derived xenograft models endowed with transplanted human immune cells are permitting evaluations of various immunotherapies and identification of specific drugs for cancer therapy. Pathogenesis and immune responses for deadly pathogens, such as Ebola and newly emerged viruses like Zika are also being studied, adding a new twist and generating new knowledge in the context of human target cells in an in vivo setting. |
| format | Online |
| id | doab-20.500.12854ir-73635 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-736352024-03-31T13:11:16Z Development of Humanized Mouse Models for Infectious Diseases and Cancer Tsuji, Moriya Akkina, Ramesh humanized mice in infectious disease research humanized mice in cancer research new humanized mouse models humanized mice for HIV malaria vaccines and therapeutics improved humanized mouse models thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology While the traditional animal models contributed immensely to biomedical research there remain many knowledge gaps in translating the results from these to humans. In this context, humanized mice transplanted with functional human cells in a physiological setting offer many advantages in deriving pre-clinical data more akin to that seen in the natural human host. There have been many recent advances in the field that encompass derivation of new transgenic breeds of immunodeficient mice harboring human cytokines and HLA alleles that permit improved human cell engraftment and differentiation. The ability to generate humanized mice with a functional immune system together with human tissue transplantation such as a functional liver has now paved the way for new experimentation not previously feasible and is beginning to shed light on the complex picture of human pathophysiology and immunopathogenesis. Specifically, human specific pathogens such as HIV, hepatitis viruses and malaria parasites are being studied in these systems and important data on pathogen life cycles in human cells in vivo, viral latency and human specific immune responses are being gathered. In the hematology front, new data are emerging on graft versus host disease using these models. Patient derived xenograft models endowed with transplanted human immune cells are permitting evaluations of various immunotherapies and identification of specific drugs for cancer therapy. Pathogenesis and immune responses for deadly pathogens, such as Ebola and newly emerged viruses like Zika are also being studied, adding a new twist and generating new knowledge in the context of human target cells in an in vivo setting. 2021-11-18T16:21:26Z 2021-11-18T16:21:26Z 2020 book ONIX_20211118_9782889634811_767 9782889634811 https://directory.doabooks.org/handle/20.500.12854/73635 eng image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5454/development-of-humanized-mouse-models-for-infectious-diseases-and-cancer#articles https://www.frontiersin.org/research-topics/5454/development-of-humanized-mouse-models-for-infectious-diseases-and-cancer#articles Frontiers Media SA 10.3389/978-2-88963-481-1 10.3389/978-2-88963-481-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889634811 169 open access |
| spellingShingle | humanized mice in infectious disease research humanized mice in cancer research new humanized mouse models humanized mice for HIV malaria vaccines and therapeutics improved humanized mouse models thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology Development of Humanized Mouse Models for Infectious Diseases and Cancer |
| title | Development of Humanized Mouse Models for Infectious Diseases and Cancer |
| title_full | Development of Humanized Mouse Models for Infectious Diseases and Cancer |
| title_fullStr | Development of Humanized Mouse Models for Infectious Diseases and Cancer |
| title_full_unstemmed | Development of Humanized Mouse Models for Infectious Diseases and Cancer |
| title_short | Development of Humanized Mouse Models for Infectious Diseases and Cancer |
| title_sort | development of humanized mouse models for infectious diseases and cancer |
| topic | humanized mice in infectious disease research humanized mice in cancer research new humanized mouse models humanized mice for HIV malaria vaccines and therapeutics improved humanized mouse models thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology |
| topic_facet | humanized mice in infectious disease research humanized mice in cancer research new humanized mouse models humanized mice for HIV malaria vaccines and therapeutics improved humanized mouse models thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology |
| url | ONIX_20211118_9782889634811_767 |