G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators
G protein-coupled receptor kinases (GRKs) and arrestins were initially identified as a pivotal player in the process of desensitization of agonist-activated G protein-coupled receptors (GPCRs). However, growing evidence suggests GRKs and arrestins fulfill a vital role in regulating a variety of cell...
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| Format: | Online |
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| Jezik: | angleščina |
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Frontiers Media SA
2021
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| Teme: | |
| Online dostop: | ONIX_20211118_9782889635474_831 |
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| _version_ | 1869523868719251456 |
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| collection | Directory of Open Access Books |
| description | G protein-coupled receptor kinases (GRKs) and arrestins were initially identified as a pivotal player in the process of desensitization of agonist-activated G protein-coupled receptors (GPCRs). However, growing evidence suggests GRKs and arrestins fulfill a vital role in regulating a variety of cellular proteins involved in signal transduction independently of GPCRs. Thus, GRKs and arrestins can interact with non-GPCRs. GRKs and arrestins may directly affect functioning of non-GPCRs or indirectly regulate non-GPCR signaling. In addition, emerging evidence supports that changes in function and/or expression of GRKs and arrestins may be important in cardiovascular, inflammatory, metabolic, or cancer pathologies. A better understanding of the pathological roles of GRKs and arrestins would provide a basis for new therapeutic targets in different human diseases. |
| format | Online |
| id | doab-20.500.12854ir-73699 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-736992024-04-04T19:19:54Z G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators Hattori, Yuichi Michel, Martin C. GRK beta-arrestins cardiovascular inflammation cancer thema EDItEUR::P Mathematics and Science::PD Science: general issues thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology G protein-coupled receptor kinases (GRKs) and arrestins were initially identified as a pivotal player in the process of desensitization of agonist-activated G protein-coupled receptors (GPCRs). However, growing evidence suggests GRKs and arrestins fulfill a vital role in regulating a variety of cellular proteins involved in signal transduction independently of GPCRs. Thus, GRKs and arrestins can interact with non-GPCRs. GRKs and arrestins may directly affect functioning of non-GPCRs or indirectly regulate non-GPCR signaling. In addition, emerging evidence supports that changes in function and/or expression of GRKs and arrestins may be important in cardiovascular, inflammatory, metabolic, or cancer pathologies. A better understanding of the pathological roles of GRKs and arrestins would provide a basis for new therapeutic targets in different human diseases. 2021-11-18T16:22:52Z 2021-11-18T16:22:52Z 2020 book ONIX_20211118_9782889635474_831 9782889635474 https://directory.doabooks.org/handle/20.500.12854/73699 eng image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/7617/g-protein-coupled-receptor-kinases-grks-and-beta-arrestins-new-insights-into-disease-regulators https://www.frontiersin.org/research-topics/7617/g-protein-coupled-receptor-kinases-grks-and-beta-arrestins-new-insights-into-disease-regulators Frontiers Media SA 10.3389/978-2-88963-547-4 10.3389/978-2-88963-547-4 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889635474 182 open access |
| spellingShingle | GRK beta-arrestins cardiovascular inflammation cancer thema EDItEUR::P Mathematics and Science::PD Science: general issues thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators |
| title | G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators |
| title_full | G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators |
| title_fullStr | G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators |
| title_full_unstemmed | G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators |
| title_short | G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators |
| title_sort | g protein coupled receptor kinases grks and beta arrestins new insights into disease regulators |
| topic | GRK beta-arrestins cardiovascular inflammation cancer thema EDItEUR::P Mathematics and Science::PD Science: general issues thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | GRK beta-arrestins cardiovascular inflammation cancer thema EDItEUR::P Mathematics and Science::PD Science: general issues thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20211118_9782889635474_831 |