Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases
Shank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with va...
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| Format: | Online |
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| Langue: | anglais |
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Frontiers Media SA
2021
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| Accès en ligne: | ONIX_20211118_9782889635672_851 |
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| description | Shank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with various domains for protein-protein interactions known to mediate direct and indirect interactions with many other synaptic proteins, including glutamate receptors, other synaptic scaffolding proteins, and signaling molecules. Importantly, Shank has been implicated in diverse neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and Phelan-McDermid syndrome, a form of developmental delay and intellectual disability. The mechanisms underlying these abnormalities, collectively termed "Shankopathies," are being actively investigated, although overall progress has been slow for many reasons. |
| format | Online |
| id | doab-20.500.12854ir-73719 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-737192024-04-04T19:20:06Z Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases Ey, Elodie Bourgeron, Thomas Maria Boeckers, Tobias Kim, Eunjoon Han, Kihoon Shank Shankopathies neuropsychiatric disorders modulating factors brain regions thema EDItEUR::P Mathematics and Science::PD Science: general issues thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Shank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with various domains for protein-protein interactions known to mediate direct and indirect interactions with many other synaptic proteins, including glutamate receptors, other synaptic scaffolding proteins, and signaling molecules. Importantly, Shank has been implicated in diverse neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and Phelan-McDermid syndrome, a form of developmental delay and intellectual disability. The mechanisms underlying these abnormalities, collectively termed "Shankopathies," are being actively investigated, although overall progress has been slow for many reasons. 2021-11-18T16:23:18Z 2021-11-18T16:23:18Z 2020 book ONIX_20211118_9782889635672_851 9782889635672 https://directory.doabooks.org/handle/20.500.12854/73719 eng image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/6607/shankopathies-shank-protein-deficiency-induced-synaptic-diseases#overview https://www.frontiersin.org/research-topics/6607/shankopathies-shank-protein-deficiency-induced-synaptic-diseases#overview Frontiers Media SA 10.3389/978-2-88963-567-2 10.3389/978-2-88963-567-2 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889635672 231 open access |
| spellingShingle | Shank Shankopathies neuropsychiatric disorders modulating factors brain regions thema EDItEUR::P Mathematics and Science::PD Science: general issues thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
| title | Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
| title_full | Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
| title_fullStr | Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
| title_full_unstemmed | Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
| title_short | Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
| title_sort | shankopathies shank protein deficiency induced synaptic diseases |
| topic | Shank Shankopathies neuropsychiatric disorders modulating factors brain regions thema EDItEUR::P Mathematics and Science::PD Science: general issues thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | Shank Shankopathies neuropsychiatric disorders modulating factors brain regions thema EDItEUR::P Mathematics and Science::PD Science: general issues thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20211118_9782889635672_851 |