The Role of Complement in Tumors
The complement system is an essential part of the innate immune system that is responsible for regulating inflammation, facilitating immune defense mechanisms, and maintaining tissue homeostasis. Despite its critical role in the regulation of immunity, the complement system has also been implicated...
保存先:
| フォーマット: | Online |
|---|---|
| 言語: | 英語 |
| 出版事項: |
Frontiers Media SA
2021
|
| 主題: | |
| オンライン･アクセス: | ONIX_20211118_9782889635764_860 |
| タグ: |
タグなし, このレコードへの初めてのタグを付けませんか!
|
| _version_ | 1869518449303093248 |
|---|---|
| collection | Directory of Open Access Books |
| description | The complement system is an essential part of the innate immune system that is responsible for regulating inflammation, facilitating immune defense mechanisms, and maintaining tissue homeostasis. Despite its critical role in the regulation of immunity, the complement system has also been implicated in the pathogenesis of a range of inflammatory diseases, including cancer. The complement system can eliminate tumor cells via complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity. In turn, cancer cells are thought to evade complement-mediated destruction by up-regulating the expression of endogenous complement inhibitors. However research over the past 10 years has demonstrated that complement proteins, in particular the complement anaphylatoxins C3a and C5a, contribute to tumor growth and metastasis. Complement proteins have been shown to also promote tumor growth indirectly, either via host immune cells to promote an immunosuppressive microenvironment or via vascular cells to promote angiogenesis. However these proteins may also affect tumor cells directly by contributing to genetic instability and by promoting tumor growth and metastatic spread. This Research Topic gives an overview of the role of complement proteins in regulating tumor development, progression and metastasis. In addition, it provides perspectives on the potential targeting of complement in cancer therapy. |
| format | Online |
| id | doab-20.500.12854ir-73728 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-737282024-03-31T13:10:57Z The Role of Complement in Tumors Rolfe, Barbara Pio, Ruben Woodruff, Trent M. Markiewski, Maciej M. Manthey, Helga D. complement cancer metastasis C5b-9 C1q C3a C5a complement regulatory proteins thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology The complement system is an essential part of the innate immune system that is responsible for regulating inflammation, facilitating immune defense mechanisms, and maintaining tissue homeostasis. Despite its critical role in the regulation of immunity, the complement system has also been implicated in the pathogenesis of a range of inflammatory diseases, including cancer. The complement system can eliminate tumor cells via complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity. In turn, cancer cells are thought to evade complement-mediated destruction by up-regulating the expression of endogenous complement inhibitors. However research over the past 10 years has demonstrated that complement proteins, in particular the complement anaphylatoxins C3a and C5a, contribute to tumor growth and metastasis. Complement proteins have been shown to also promote tumor growth indirectly, either via host immune cells to promote an immunosuppressive microenvironment or via vascular cells to promote angiogenesis. However these proteins may also affect tumor cells directly by contributing to genetic instability and by promoting tumor growth and metastatic spread. This Research Topic gives an overview of the role of complement proteins in regulating tumor development, progression and metastasis. In addition, it provides perspectives on the potential targeting of complement in cancer therapy. 2021-11-18T16:23:28Z 2021-11-18T16:23:28Z 2020 book ONIX_20211118_9782889635764_860 9782889635764 https://directory.doabooks.org/handle/20.500.12854/73728 eng image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/8435/the-role-of-complement-in-tumors#overview https://www.frontiersin.org/research-topics/8435/the-role-of-complement-in-tumors#overview Frontiers Media SA 10.3389/978-2-88963-576-4 10.3389/978-2-88963-576-4 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889635764 107 open access |
| spellingShingle | complement cancer metastasis C5b-9 C1q C3a C5a complement regulatory proteins thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology The Role of Complement in Tumors |
| title | The Role of Complement in Tumors |
| title_full | The Role of Complement in Tumors |
| title_fullStr | The Role of Complement in Tumors |
| title_full_unstemmed | The Role of Complement in Tumors |
| title_short | The Role of Complement in Tumors |
| title_sort | role of complement in tumors |
| topic | complement cancer metastasis C5b-9 C1q C3a C5a complement regulatory proteins thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology |
| topic_facet | complement cancer metastasis C5b-9 C1q C3a C5a complement regulatory proteins thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology |
| url | ONIX_20211118_9782889635764_860 |