Innate Immunity Programming and Memory in Resolving and Non-Resolving Inflammation
There is increasing evidence that suggest the presence of innate immune memory as reflected in the altered responses from programmed innate leukocyte challenged with varying natures and signal strength of inflammatory challenges. The rudimentary “memory” responses of innate leukocytes based on prior...
সংরক্ষণ করুন:
| বিন্যাস: | Online |
|---|---|
| ভাষা: | ইংরেজি |
| প্রকাশিত: |
Frontiers Media SA
2021
|
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | ONIX_20211118_9782889635825_866 |
| ট্যাগগুলো: |
কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!
|
| _version_ | 1869520859575615488 |
|---|---|
| collection | Directory of Open Access Books |
| description | There is increasing evidence that suggest the presence of innate immune memory as reflected in the altered responses from programmed innate leukocyte challenged with varying natures and signal strength of inflammatory challenges. The rudimentary “memory” responses of innate leukocytes based on prior challenge histories, as well as signal strength and durations, may dramatically affect cellular and tissue homeostasis. At the translational level, innate leukocyte memory may underlie the decision making process of resolving tissue homeostasis as compared to non-resolving inflammatory diseases. Proper resolution of leukocyte homeostasis is essential for the well-being of human physiology such as proper wound repair, eradication of sporadic malignant cells, mucosal defense of infections, and tissue regeneration and growth. On the other hand, lack of inflammation resolution underlies the pathogenesis of wide ranges of acute and chronic diseases ranging from cardiovascular to neurological diseases and cancer. This series of reports will focus on this emerging topics of innate leukocyte programming dynamics and memory in health and disease. Emerging examples of leukocyte programming dynamics may include the following scenarios. First, sequential challenges with distinct inflammatory signals may alter the leukocyte expression profiles of inflammatory mediators, as exemplified by the classically trained M1 monocyte/macrophage as compared to the alternatively programmed M2 macrophages. Second, leukocytes may be adapted to unique signal strength of inflammatory challenges, as reflected in the generation of non-resolving low-grade inflammatory monocytes adapted by chronic low signals of TLR4/7 agonists. Third, the ontogeny of innate leukocytes from precursor cells as well as the life span of mature leukocytes may also be significantly impacted by the history, dosage, and duration of inflammatory signals. In light of the conceptual and translational significance of innate immune memory, this topic may cover the key aspects listed below. 1) Monocyte priming and tolerance; 2) Neutrophil priming and adaptation; 3) NK cell priming; 4) Cross-talk among innate and adaptive immune programming; 5) Innate leukocyte programming in acute and chronic inflammatory disease. |
| format | Online |
| id | doab-20.500.12854ir-73734 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-737342024-03-31T13:11:01Z Innate Immunity Programming and Memory in Resolving and Non-Resolving Inflammation Li, Liwu McCall, Charles E. Hu, Xiaoyu innate immune memory inflammation dynamics resolving and non-resolving inflammation acute disease chronic disease thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology There is increasing evidence that suggest the presence of innate immune memory as reflected in the altered responses from programmed innate leukocyte challenged with varying natures and signal strength of inflammatory challenges. The rudimentary “memory” responses of innate leukocytes based on prior challenge histories, as well as signal strength and durations, may dramatically affect cellular and tissue homeostasis. At the translational level, innate leukocyte memory may underlie the decision making process of resolving tissue homeostasis as compared to non-resolving inflammatory diseases. Proper resolution of leukocyte homeostasis is essential for the well-being of human physiology such as proper wound repair, eradication of sporadic malignant cells, mucosal defense of infections, and tissue regeneration and growth. On the other hand, lack of inflammation resolution underlies the pathogenesis of wide ranges of acute and chronic diseases ranging from cardiovascular to neurological diseases and cancer. This series of reports will focus on this emerging topics of innate leukocyte programming dynamics and memory in health and disease. Emerging examples of leukocyte programming dynamics may include the following scenarios. First, sequential challenges with distinct inflammatory signals may alter the leukocyte expression profiles of inflammatory mediators, as exemplified by the classically trained M1 monocyte/macrophage as compared to the alternatively programmed M2 macrophages. Second, leukocytes may be adapted to unique signal strength of inflammatory challenges, as reflected in the generation of non-resolving low-grade inflammatory monocytes adapted by chronic low signals of TLR4/7 agonists. Third, the ontogeny of innate leukocytes from precursor cells as well as the life span of mature leukocytes may also be significantly impacted by the history, dosage, and duration of inflammatory signals. In light of the conceptual and translational significance of innate immune memory, this topic may cover the key aspects listed below. 1) Monocyte priming and tolerance; 2) Neutrophil priming and adaptation; 3) NK cell priming; 4) Cross-talk among innate and adaptive immune programming; 5) Innate leukocyte programming in acute and chronic inflammatory disease. 2021-11-18T16:23:37Z 2021-11-18T16:23:37Z 2020 book ONIX_20211118_9782889635825_866 9782889635825 https://directory.doabooks.org/handle/20.500.12854/73734 eng image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5497/innate-immunity-programming-and-memory-in-resolving-and-non-resolving-inflammation#overview https://www.frontiersin.org/research-topics/5497/innate-immunity-programming-and-memory-in-resolving-and-non-resolving-inflammation#overview Frontiers Media SA 10.3389/978-2-88963-582-5 10.3389/978-2-88963-582-5 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889635825 139 open access |
| spellingShingle | innate immune memory inflammation dynamics resolving and non-resolving inflammation acute disease chronic disease thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology Innate Immunity Programming and Memory in Resolving and Non-Resolving Inflammation |
| title | Innate Immunity Programming and Memory in Resolving and Non-Resolving Inflammation |
| title_full | Innate Immunity Programming and Memory in Resolving and Non-Resolving Inflammation |
| title_fullStr | Innate Immunity Programming and Memory in Resolving and Non-Resolving Inflammation |
| title_full_unstemmed | Innate Immunity Programming and Memory in Resolving and Non-Resolving Inflammation |
| title_short | Innate Immunity Programming and Memory in Resolving and Non-Resolving Inflammation |
| title_sort | innate immunity programming and memory in resolving and non resolving inflammation |
| topic | innate immune memory inflammation dynamics resolving and non-resolving inflammation acute disease chronic disease thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology |
| topic_facet | innate immune memory inflammation dynamics resolving and non-resolving inflammation acute disease chronic disease thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology |
| url | ONIX_20211118_9782889635825_866 |