T Cell Differentiation and Function in Tissue Inflammation
Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation....
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| Format: | Online |
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| Language: | English |
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Frontiers Media SA
2021
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| Online Access: | ONIX_20211118_9782889636143_888 |
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| description | Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the other hand, regulatory cells such as Foxp3+Tregs and Tr1 cells are essential to control functions of effector T cells and maintain tissue homeostasis. Distinct transcriptional and molecular pathways have been identified for the generation of various effector and regulatory T cells. Emerging molecular signatures of these effectors and of regulatory T cells indicate plasticity in their developmental pathways, which is dictated by the tissue microenvironment and by other factors including cytokines and transcription factors. |
| format | Online |
| id | doab-20.500.12854ir-73756 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-737562024-03-31T13:11:14Z T Cell Differentiation and Function in Tissue Inflammation Awasthi, Amit Goswami, Ritobrata CD4 T cell CD8 T cell Cancer autoimmune disease Inflammation thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the other hand, regulatory cells such as Foxp3+Tregs and Tr1 cells are essential to control functions of effector T cells and maintain tissue homeostasis. Distinct transcriptional and molecular pathways have been identified for the generation of various effector and regulatory T cells. Emerging molecular signatures of these effectors and of regulatory T cells indicate plasticity in their developmental pathways, which is dictated by the tissue microenvironment and by other factors including cytokines and transcription factors. 2021-11-18T16:24:08Z 2021-11-18T16:24:08Z 2020 book ONIX_20211118_9782889636143_888 9782889636143 https://directory.doabooks.org/handle/20.500.12854/73756 eng image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/6209/t-cell-differentiation-and-function-in-tissue-inflammation https://www.frontiersin.org/research-topics/6209/t-cell-differentiation-and-function-in-tissue-inflammation Frontiers Media SA 10.3389/978-2-88963-614-3 10.3389/978-2-88963-614-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889636143 231 open access |
| spellingShingle | CD4 T cell CD8 T cell Cancer autoimmune disease Inflammation thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology T Cell Differentiation and Function in Tissue Inflammation |
| title | T Cell Differentiation and Function in Tissue Inflammation |
| title_full | T Cell Differentiation and Function in Tissue Inflammation |
| title_fullStr | T Cell Differentiation and Function in Tissue Inflammation |
| title_full_unstemmed | T Cell Differentiation and Function in Tissue Inflammation |
| title_short | T Cell Differentiation and Function in Tissue Inflammation |
| title_sort | t cell differentiation and function in tissue inflammation |
| topic | CD4 T cell CD8 T cell Cancer autoimmune disease Inflammation thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology |
| topic_facet | CD4 T cell CD8 T cell Cancer autoimmune disease Inflammation thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCM Immunology |
| url | ONIX_20211118_9782889636143_888 |