3Ts in Gastrointestinal Microbiome Era: Technology, Translational Research and Transplant
We have entered a new era where some concepts of the complex community of microorganisms (microbiota comprising bacteria, fungi, viruses, bacteriophages and helminths) are being re-discovered and re-visited. Microbiota and human interaction is not new; they have shared a long history of co-existence...
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| Materialtyp: | Online |
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| Språk: | engelska |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Länkar: | ONIX_20220111_9783036527963_1006 |
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| collection | Directory of Open Access Books |
| description | We have entered a new era where some concepts of the complex community of microorganisms (microbiota comprising bacteria, fungi, viruses, bacteriophages and helminths) are being re-discovered and re-visited. Microbiota and human interaction is not new; they have shared a long history of co-existence. Nevertheless, the opportunities to understand the role of these microorganisms in human diseases and to design a potential treatment were limited. At present, thanks to development of innovative and cutting-edge molecular biological and microbiological technologies as well as clinical informatics and bioinformatics skills, microbiome application is moving into clinics. Approaches to therapy based on prebiotics, probiotics and lately on fecal microbiota transplantation has revolutionized medicine. Microbiota outnumbers our genes and is now regarded as another organ of the body. The gastrointestinal tract and gut microbiota display a well-documented symbiotic relationship. Disruption of intestinal microbiota homeostasis—called dysbiosis—has been associated with several diseases. Whether dysbiosis is a cause or consequence of disease initiation and progression still needs to be investigated in more depth. The aim of this book is to highlight recent advances in the field of microbiome research, which are now shaping medicine, and current approaches to microbiome-oriented therapy for gastrointestinal diseases. Dr. Rinaldo Pellicano Dr. Sharmila Fagoonee Guest Editors |
| format | Online |
| id | doab-20.500.12854ir-76262 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
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| spelling | doab-20.500.12854ir-762622024-03-31T13:09:02Z 3Ts in Gastrointestinal Microbiome Era: Technology, Translational Research and Transplant Pellicano, Rinaldo Fagoonee, Sharmila Bacteroides ovatus Bifidobacterium adolescentis Dysbiosis Faecalibacterium prausnitzii Ruminococcus gnavus type 1 diabetes microbiota microbiome auto-immunity gut permeability gut IBS celiac disease enteropathy gluten therapy gut microbiota precision medicine Clostridium difficile inflammatory bowel disease ulcerative colitis irritable bowel disease metabolic syndrome gastric microbiota transient persistent culture sequencing Helicobacter pylori fecal microbiota transplantation feces donor fecal microbiota flow cytometry viability of bacteria next-generation sequencing culturing of fecal microbiota Alzheimer’s disease microbiota–gut–brain axis neurodegenerative disease intestinal flora necrotizing enterocolitis intestinal microbiology infant gut metabolomics IL-6 IL-8 IL-12p70 intestinal permeability zonulin gut virome steatosis cirrhosis hepatocellular carcinoma gastrointestinal technology high-throughput crohn’s disease mononuclear cells transient receptor potential channel pancreatic diseases acute pancreatitis chronic pancreatitis diabetes mellitus pancreatic ductal adenocarcinoma pancreatic cystic neoplasms thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine We have entered a new era where some concepts of the complex community of microorganisms (microbiota comprising bacteria, fungi, viruses, bacteriophages and helminths) are being re-discovered and re-visited. Microbiota and human interaction is not new; they have shared a long history of co-existence. Nevertheless, the opportunities to understand the role of these microorganisms in human diseases and to design a potential treatment were limited. At present, thanks to development of innovative and cutting-edge molecular biological and microbiological technologies as well as clinical informatics and bioinformatics skills, microbiome application is moving into clinics. Approaches to therapy based on prebiotics, probiotics and lately on fecal microbiota transplantation has revolutionized medicine. Microbiota outnumbers our genes and is now regarded as another organ of the body. The gastrointestinal tract and gut microbiota display a well-documented symbiotic relationship. Disruption of intestinal microbiota homeostasis—called dysbiosis—has been associated with several diseases. Whether dysbiosis is a cause or consequence of disease initiation and progression still needs to be investigated in more depth. The aim of this book is to highlight recent advances in the field of microbiome research, which are now shaping medicine, and current approaches to microbiome-oriented therapy for gastrointestinal diseases. Dr. Rinaldo Pellicano Dr. Sharmila Fagoonee Guest Editors 2022-01-11T13:22:28Z 2022-01-11T13:22:28Z 2021 book ONIX_20220111_9783036527963_1006 9783036527963 9783036527970 https://directory.doabooks.org/handle/20.500.12854/76262 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4793 https://mdpi.com/books/pdfview/book/4793 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-2797-0 10.3390/books978-3-0365-2797-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036527963 9783036527970 236 Basel, Switzerland open access |
| spellingShingle | Bacteroides ovatus Bifidobacterium adolescentis Dysbiosis Faecalibacterium prausnitzii Ruminococcus gnavus type 1 diabetes microbiota microbiome auto-immunity gut permeability gut IBS celiac disease enteropathy gluten therapy gut microbiota precision medicine Clostridium difficile inflammatory bowel disease ulcerative colitis irritable bowel disease metabolic syndrome gastric microbiota transient persistent culture sequencing Helicobacter pylori fecal microbiota transplantation feces donor fecal microbiota flow cytometry viability of bacteria next-generation sequencing culturing of fecal microbiota Alzheimer’s disease microbiota–gut–brain axis neurodegenerative disease intestinal flora necrotizing enterocolitis intestinal microbiology infant gut metabolomics IL-6 IL-8 IL-12p70 intestinal permeability zonulin gut virome steatosis cirrhosis hepatocellular carcinoma gastrointestinal technology high-throughput crohn’s disease mononuclear cells transient receptor potential channel pancreatic diseases acute pancreatitis chronic pancreatitis diabetes mellitus pancreatic ductal adenocarcinoma pancreatic cystic neoplasms thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine 3Ts in Gastrointestinal Microbiome Era: Technology, Translational Research and Transplant |
| title | 3Ts in Gastrointestinal Microbiome Era: Technology, Translational Research and Transplant |
| title_full | 3Ts in Gastrointestinal Microbiome Era: Technology, Translational Research and Transplant |
| title_fullStr | 3Ts in Gastrointestinal Microbiome Era: Technology, Translational Research and Transplant |
| title_full_unstemmed | 3Ts in Gastrointestinal Microbiome Era: Technology, Translational Research and Transplant |
| title_short | 3Ts in Gastrointestinal Microbiome Era: Technology, Translational Research and Transplant |
| title_sort | 3ts in gastrointestinal microbiome era technology translational research and transplant |
| topic | Bacteroides ovatus Bifidobacterium adolescentis Dysbiosis Faecalibacterium prausnitzii Ruminococcus gnavus type 1 diabetes microbiota microbiome auto-immunity gut permeability gut IBS celiac disease enteropathy gluten therapy gut microbiota precision medicine Clostridium difficile inflammatory bowel disease ulcerative colitis irritable bowel disease metabolic syndrome gastric microbiota transient persistent culture sequencing Helicobacter pylori fecal microbiota transplantation feces donor fecal microbiota flow cytometry viability of bacteria next-generation sequencing culturing of fecal microbiota Alzheimer’s disease microbiota–gut–brain axis neurodegenerative disease intestinal flora necrotizing enterocolitis intestinal microbiology infant gut metabolomics IL-6 IL-8 IL-12p70 intestinal permeability zonulin gut virome steatosis cirrhosis hepatocellular carcinoma gastrointestinal technology high-throughput crohn’s disease mononuclear cells transient receptor potential channel pancreatic diseases acute pancreatitis chronic pancreatitis diabetes mellitus pancreatic ductal adenocarcinoma pancreatic cystic neoplasms thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine |
| topic_facet | Bacteroides ovatus Bifidobacterium adolescentis Dysbiosis Faecalibacterium prausnitzii Ruminococcus gnavus type 1 diabetes microbiota microbiome auto-immunity gut permeability gut IBS celiac disease enteropathy gluten therapy gut microbiota precision medicine Clostridium difficile inflammatory bowel disease ulcerative colitis irritable bowel disease metabolic syndrome gastric microbiota transient persistent culture sequencing Helicobacter pylori fecal microbiota transplantation feces donor fecal microbiota flow cytometry viability of bacteria next-generation sequencing culturing of fecal microbiota Alzheimer’s disease microbiota–gut–brain axis neurodegenerative disease intestinal flora necrotizing enterocolitis intestinal microbiology infant gut metabolomics IL-6 IL-8 IL-12p70 intestinal permeability zonulin gut virome steatosis cirrhosis hepatocellular carcinoma gastrointestinal technology high-throughput crohn’s disease mononuclear cells transient receptor potential channel pancreatic diseases acute pancreatitis chronic pancreatitis diabetes mellitus pancreatic ductal adenocarcinoma pancreatic cystic neoplasms thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine |
| url | ONIX_20220111_9783036527963_1006 |