Immunohistochemical Expression
Immunohistochemistry (IHC) is an ancillary method, widely used in pathologists’ practice, that allows identifying diagnostic and prognostic/predictive of therapeutic response protein markers on tissue samples by the use of specific monoclonal antibodies and chromogenic substances that guarantee the...
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| Format: | Online |
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| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Online Access: | ONIX_20220111_9783036504001_168 |
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| collection | Directory of Open Access Books |
| description | Immunohistochemistry (IHC) is an ancillary method, widely used in pathologists’ practice, that allows identifying diagnostic and prognostic/predictive of therapeutic response protein markers on tissue samples by the use of specific monoclonal antibodies and chromogenic substances that guarantee the visualization of an antibody–antigene binding complex under a light microscope [1]. Coon et al., in 1941 [2], first introduced the use of fluorochrome-conjugated antibodies in clinical practice. Since then, IHC has gone from being a useful tool for identifying the differentiation line of otherwise undifferentiated cells to a technique capable of providing not only diagnostic but also prognostic and predictive indications of responses to specific therapeutic options [1,3]. The abovementioned peculiarities have made IHC one of the most used ancillary methods in the histopathological approach to human neoplastic and non-neoplastic diseases [3-5]. This Special Issue contains 11 accepted papers that provide readers with a comprehensive update on current and future applications of IHC in medical practice. |
| format | Online |
| id | doab-20.500.12854ir-76432 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-764322024-03-30T23:22:02Z Immunohistochemical Expression Caltabiano, Rosario Loreto, Carla training exercise NGAL VDR kidney heart immunohistochemistry ABCB5 uveal melanoma prognosis metastasis pericardium cytokeratin c-kit PDGFR initial lymphatics macroH2A prognostic factor SLC22A12 URAT1 hypouricemia uric acid transporters excretion fraction of uric acid Hsp27 Hsp60 Hsp70 Hsp90 molecular chaperone chaperonopathies thyroid follicular adenoma follicular carcinoma differential diagnosis carcinogenesis matrix metalloproteinases temporomandibular joint disorder temporomandibular joint DEN liver inflammation ultra-structural changes oxidative stress EGCG Vitamin D prostate cancer urinary tract malformations megacystis enteric nervous system outcome and prognosis WT1 human embryonal/fetal tissues neoplastic tissue n/a thema EDItEUR::M Medicine and Nursing Immunohistochemistry (IHC) is an ancillary method, widely used in pathologists’ practice, that allows identifying diagnostic and prognostic/predictive of therapeutic response protein markers on tissue samples by the use of specific monoclonal antibodies and chromogenic substances that guarantee the visualization of an antibody–antigene binding complex under a light microscope [1]. Coon et al., in 1941 [2], first introduced the use of fluorochrome-conjugated antibodies in clinical practice. Since then, IHC has gone from being a useful tool for identifying the differentiation line of otherwise undifferentiated cells to a technique capable of providing not only diagnostic but also prognostic and predictive indications of responses to specific therapeutic options [1,3]. The abovementioned peculiarities have made IHC one of the most used ancillary methods in the histopathological approach to human neoplastic and non-neoplastic diseases [3-5]. This Special Issue contains 11 accepted papers that provide readers with a comprehensive update on current and future applications of IHC in medical practice. 2022-01-11T13:31:44Z 2022-01-11T13:31:44Z 2021 book ONIX_20220111_9783036504001_168 9783036504001 9783036504018 https://directory.doabooks.org/handle/20.500.12854/76432 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/3867 https://mdpi.com/books/pdfview/book/3867 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-0401-8 10.3390/books978-3-0365-0401-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036504001 9783036504018 168 Basel, Switzerland open access |
| spellingShingle | training exercise NGAL VDR kidney heart immunohistochemistry ABCB5 uveal melanoma prognosis metastasis pericardium cytokeratin c-kit PDGFR initial lymphatics macroH2A prognostic factor SLC22A12 URAT1 hypouricemia uric acid transporters excretion fraction of uric acid Hsp27 Hsp60 Hsp70 Hsp90 molecular chaperone chaperonopathies thyroid follicular adenoma follicular carcinoma differential diagnosis carcinogenesis matrix metalloproteinases temporomandibular joint disorder temporomandibular joint DEN liver inflammation ultra-structural changes oxidative stress EGCG Vitamin D prostate cancer urinary tract malformations megacystis enteric nervous system outcome and prognosis WT1 human embryonal/fetal tissues neoplastic tissue n/a thema EDItEUR::M Medicine and Nursing Immunohistochemical Expression |
| title | Immunohistochemical Expression |
| title_full | Immunohistochemical Expression |
| title_fullStr | Immunohistochemical Expression |
| title_full_unstemmed | Immunohistochemical Expression |
| title_short | Immunohistochemical Expression |
| title_sort | immunohistochemical expression |
| topic | training exercise NGAL VDR kidney heart immunohistochemistry ABCB5 uveal melanoma prognosis metastasis pericardium cytokeratin c-kit PDGFR initial lymphatics macroH2A prognostic factor SLC22A12 URAT1 hypouricemia uric acid transporters excretion fraction of uric acid Hsp27 Hsp60 Hsp70 Hsp90 molecular chaperone chaperonopathies thyroid follicular adenoma follicular carcinoma differential diagnosis carcinogenesis matrix metalloproteinases temporomandibular joint disorder temporomandibular joint DEN liver inflammation ultra-structural changes oxidative stress EGCG Vitamin D prostate cancer urinary tract malformations megacystis enteric nervous system outcome and prognosis WT1 human embryonal/fetal tissues neoplastic tissue n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | training exercise NGAL VDR kidney heart immunohistochemistry ABCB5 uveal melanoma prognosis metastasis pericardium cytokeratin c-kit PDGFR initial lymphatics macroH2A prognostic factor SLC22A12 URAT1 hypouricemia uric acid transporters excretion fraction of uric acid Hsp27 Hsp60 Hsp70 Hsp90 molecular chaperone chaperonopathies thyroid follicular adenoma follicular carcinoma differential diagnosis carcinogenesis matrix metalloproteinases temporomandibular joint disorder temporomandibular joint DEN liver inflammation ultra-structural changes oxidative stress EGCG Vitamin D prostate cancer urinary tract malformations megacystis enteric nervous system outcome and prognosis WT1 human embryonal/fetal tissues neoplastic tissue n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20220111_9783036504001_168 |