P38 Signaling Pathway
p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases h...
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| Formaat: | Online |
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| Taal: | Engels |
| Gepubliceerd in: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Onderwerpen: | |
| Online toegang: | ONIX_20220111_9783036508580_209 |
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| _version_ | 1869524581485641728 |
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| collection | Directory of Open Access Books |
| description | p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity. |
| format | Online |
| id | doab-20.500.12854ir-76473 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-764732024-03-27T16:34:38Z P38 Signaling Pathway Cuenda, Ana Sanz Ezquerro, Juan José arginine methylation erythroid differentiation MKK3 phosphorylation, PRMT1 p38 MAPK cocaine conditioned place preference reward stress anxiety depression nucleus accumbens social interaction k opioid receptors p38α Rab5 endosome Alzheimer’s Lewy Bodies amyloid-β tau α-synuclein p38-MAPK α inhibitor Alzheimer’s disease synaptic plasticity neuroinflammation β-amyloid Tau Kv4.2 seizure temporal lobe epilepsy hippocampus neuronal firing and excitability p38MAPK nuclear translocation β-like importins inflammation cancer skeletal muscle energy metabolism signal transduction exercise type 2 diabetes p38 mitogen-activated protein kinase bleomycin-induced pulmonary fibrosis idiopathic pulmonary fibrosis RNA sequencing alveolar epithelial type II cells MAPK p38 physiology metabolism signaling hypoxia arrhythmia MAPK11 p38β n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity. 2022-01-11T13:32:53Z 2022-01-11T13:32:53Z 2021 book ONIX_20220111_9783036508580_209 9783036508580 9783036508597 https://directory.doabooks.org/handle/20.500.12854/76473 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/3909 https://mdpi.com/books/pdfview/book/3909 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-0859-7 10.3390/books978-3-0365-0859-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036508580 9783036508597 194 Basel, Switzerland open access |
| spellingShingle | arginine methylation erythroid differentiation MKK3 phosphorylation, PRMT1 p38 MAPK cocaine conditioned place preference reward stress anxiety depression nucleus accumbens social interaction k opioid receptors p38α Rab5 endosome Alzheimer’s Lewy Bodies amyloid-β tau α-synuclein p38-MAPK α inhibitor Alzheimer’s disease synaptic plasticity neuroinflammation β-amyloid Tau Kv4.2 seizure temporal lobe epilepsy hippocampus neuronal firing and excitability p38MAPK nuclear translocation β-like importins inflammation cancer skeletal muscle energy metabolism signal transduction exercise type 2 diabetes p38 mitogen-activated protein kinase bleomycin-induced pulmonary fibrosis idiopathic pulmonary fibrosis RNA sequencing alveolar epithelial type II cells MAPK p38 physiology metabolism signaling hypoxia arrhythmia MAPK11 p38β n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general P38 Signaling Pathway |
| title | P38 Signaling Pathway |
| title_full | P38 Signaling Pathway |
| title_fullStr | P38 Signaling Pathway |
| title_full_unstemmed | P38 Signaling Pathway |
| title_short | P38 Signaling Pathway |
| title_sort | p38 signaling pathway |
| topic | arginine methylation erythroid differentiation MKK3 phosphorylation, PRMT1 p38 MAPK cocaine conditioned place preference reward stress anxiety depression nucleus accumbens social interaction k opioid receptors p38α Rab5 endosome Alzheimer’s Lewy Bodies amyloid-β tau α-synuclein p38-MAPK α inhibitor Alzheimer’s disease synaptic plasticity neuroinflammation β-amyloid Tau Kv4.2 seizure temporal lobe epilepsy hippocampus neuronal firing and excitability p38MAPK nuclear translocation β-like importins inflammation cancer skeletal muscle energy metabolism signal transduction exercise type 2 diabetes p38 mitogen-activated protein kinase bleomycin-induced pulmonary fibrosis idiopathic pulmonary fibrosis RNA sequencing alveolar epithelial type II cells MAPK p38 physiology metabolism signaling hypoxia arrhythmia MAPK11 p38β n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general |
| topic_facet | arginine methylation erythroid differentiation MKK3 phosphorylation, PRMT1 p38 MAPK cocaine conditioned place preference reward stress anxiety depression nucleus accumbens social interaction k opioid receptors p38α Rab5 endosome Alzheimer’s Lewy Bodies amyloid-β tau α-synuclein p38-MAPK α inhibitor Alzheimer’s disease synaptic plasticity neuroinflammation β-amyloid Tau Kv4.2 seizure temporal lobe epilepsy hippocampus neuronal firing and excitability p38MAPK nuclear translocation β-like importins inflammation cancer skeletal muscle energy metabolism signal transduction exercise type 2 diabetes p38 mitogen-activated protein kinase bleomycin-induced pulmonary fibrosis idiopathic pulmonary fibrosis RNA sequencing alveolar epithelial type II cells MAPK p38 physiology metabolism signaling hypoxia arrhythmia MAPK11 p38β n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general |
| url | ONIX_20220111_9783036508580_209 |