Insulin-Like Growth Factors in Development, Cancers and Aging
This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IG...
保存先:
| フォーマット: | Online |
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| 言語: | 英語 |
| 出版事項: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| 主題: | |
| オンライン･アクセス: | ONIX_20220111_9783036507705_222 |
| タグ: |
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| _version_ | 1869530582790176768 |
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| collection | Directory of Open Access Books |
| description | This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology. The present Special Issue highlights some of the most important topics in the broad area of IGF research, including the role of IGF1 in aging and longevity, attempts to target the IGF1 axis in oncology, the role of IGF-binding proteins, structural aspects of IGF-II, etc. We trust that this assembly of articles will be of great help to students, basic researchers and practitioners. |
| format | Online |
| id | doab-20.500.12854ir-76486 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-764862024-03-28T03:30:38Z Insulin-Like Growth Factors in Development, Cancers and Aging Werner, Haim IGF-I IGF-II insulin IGF-IR IRs tyrosine kinase receptor GPCRs hybrids phosphorylation G-proteins β-arrestins functional RTK/GPCR hybrid nuclear translocation IGF-I receptor signaling targeted therapeutics IGF-Trap IGF system IGFBP-3 IGFBP-3R TMEM219 anti-tumor anti-metastatic agonists mAb therapy IGF-1 IGFBP-1 older adults longevity health-span age-related disease cognitive impairment diabetes mitochondria growth hormone insulin-like growth factor-1 aging oxidative stress senescence longitudinal study IGFBP mouse models skeletal muscle MSCs myogenesis glucose regulated protein (GRP) 94 insulin-like growth factor obligate chaperone hypertrophy atrophy cachexia muscle regeneration autophagy IGF-1R insulin receptor IR-A structural studies receptor activation n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology. The present Special Issue highlights some of the most important topics in the broad area of IGF research, including the role of IGF1 in aging and longevity, attempts to target the IGF1 axis in oncology, the role of IGF-binding proteins, structural aspects of IGF-II, etc. We trust that this assembly of articles will be of great help to students, basic researchers and practitioners. 2022-01-11T13:33:18Z 2022-01-11T13:33:18Z 2021 book ONIX_20220111_9783036507705_222 9783036507705 9783036507712 https://directory.doabooks.org/handle/20.500.12854/76486 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/3932 https://mdpi.com/books/pdfview/book/3932 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-0771-2 10.3390/books978-3-0365-0771-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036507705 9783036507712 196 Basel, Switzerland open access |
| spellingShingle | IGF-I IGF-II insulin IGF-IR IRs tyrosine kinase receptor GPCRs hybrids phosphorylation G-proteins β-arrestins functional RTK/GPCR hybrid nuclear translocation IGF-I receptor signaling targeted therapeutics IGF-Trap IGF system IGFBP-3 IGFBP-3R TMEM219 anti-tumor anti-metastatic agonists mAb therapy IGF-1 IGFBP-1 older adults longevity health-span age-related disease cognitive impairment diabetes mitochondria growth hormone insulin-like growth factor-1 aging oxidative stress senescence longitudinal study IGFBP mouse models skeletal muscle MSCs myogenesis glucose regulated protein (GRP) 94 insulin-like growth factor obligate chaperone hypertrophy atrophy cachexia muscle regeneration autophagy IGF-1R insulin receptor IR-A structural studies receptor activation n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Insulin-Like Growth Factors in Development, Cancers and Aging |
| title | Insulin-Like Growth Factors in Development, Cancers and Aging |
| title_full | Insulin-Like Growth Factors in Development, Cancers and Aging |
| title_fullStr | Insulin-Like Growth Factors in Development, Cancers and Aging |
| title_full_unstemmed | Insulin-Like Growth Factors in Development, Cancers and Aging |
| title_short | Insulin-Like Growth Factors in Development, Cancers and Aging |
| title_sort | insulin like growth factors in development cancers and aging |
| topic | IGF-I IGF-II insulin IGF-IR IRs tyrosine kinase receptor GPCRs hybrids phosphorylation G-proteins β-arrestins functional RTK/GPCR hybrid nuclear translocation IGF-I receptor signaling targeted therapeutics IGF-Trap IGF system IGFBP-3 IGFBP-3R TMEM219 anti-tumor anti-metastatic agonists mAb therapy IGF-1 IGFBP-1 older adults longevity health-span age-related disease cognitive impairment diabetes mitochondria growth hormone insulin-like growth factor-1 aging oxidative stress senescence longitudinal study IGFBP mouse models skeletal muscle MSCs myogenesis glucose regulated protein (GRP) 94 insulin-like growth factor obligate chaperone hypertrophy atrophy cachexia muscle regeneration autophagy IGF-1R insulin receptor IR-A structural studies receptor activation n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | IGF-I IGF-II insulin IGF-IR IRs tyrosine kinase receptor GPCRs hybrids phosphorylation G-proteins β-arrestins functional RTK/GPCR hybrid nuclear translocation IGF-I receptor signaling targeted therapeutics IGF-Trap IGF system IGFBP-3 IGFBP-3R TMEM219 anti-tumor anti-metastatic agonists mAb therapy IGF-1 IGFBP-1 older adults longevity health-span age-related disease cognitive impairment diabetes mitochondria growth hormone insulin-like growth factor-1 aging oxidative stress senescence longitudinal study IGFBP mouse models skeletal muscle MSCs myogenesis glucose regulated protein (GRP) 94 insulin-like growth factor obligate chaperone hypertrophy atrophy cachexia muscle regeneration autophagy IGF-1R insulin receptor IR-A structural studies receptor activation n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20220111_9783036507705_222 |