Protein-Ligand Interactions: Target Identification and Drug Discovery
Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of th...
Պահպանված է:
| Ձևաչափ: | Online |
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| Լեզու: | անգլերեն |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Խորագրեր: | |
| Առցանց հասանելիություն: | ONIX_20220111_9783036510507_344 |
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Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
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| _version_ | 1869519807312822272 |
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| collection | Directory of Open Access Books |
| description | Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of the molecular processes and the cellular pathways involved in each pathological condition and disease, but also the specific protein targets and the effects of drug binding on protein conformation and activity. Understanding of how drugs can modify and modulate specific cellular pathways and functions will be helpful during the process of drug development and clinical trials. |
| format | Online |
| id | doab-20.500.12854ir-76609 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-766092024-03-28T03:32:52Z Protein-Ligand Interactions: Target Identification and Drug Discovery Altieri, Fabio serum half-life extension fatty acid conjugation FcRn-mediated recycling serum albumin translocator protein (TSPO) CoCl2 mitochondrial membrane potential reactive oxygen species (ROS) cell viability cell death lung cancer cell line acetylcholinesterase amyloid beta aggregation neuroprotection molecular docking multi-target drug structure–activity relationship brassicasterol phytosterols HSV Mycobacterium tuberculosis HSV-1 DNA polymerase HSV-1 TK human CDK2 ACE UDP-galactopyranose mutase heat shock protein 70 Hsp70 piperine fluorescence spectroscopy molecular dynamics molecular biophysics GADD45β MKK7 multiple myeloma protein-ligand interaction STD-NMR sigma receptors sigma ligands cancer SIGMAR1 PGRMC1 TMEM97 NCI60 COMPARE analysis membrane lipid-protein interaction lipid signalling kinase regulation phosphatidylinositols molecular docking simulation target identification small-molecule derivatives of salicylanilide drug discovery drug development thyroid diseases endocrine disruptor compound human umbilical artery vascular homeostasis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of the molecular processes and the cellular pathways involved in each pathological condition and disease, but also the specific protein targets and the effects of drug binding on protein conformation and activity. Understanding of how drugs can modify and modulate specific cellular pathways and functions will be helpful during the process of drug development and clinical trials. 2022-01-11T13:36:54Z 2022-01-11T13:36:54Z 2021 book ONIX_20220111_9783036510507_344 9783036510507 9783036510514 https://directory.doabooks.org/handle/20.500.12854/76609 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4054 https://mdpi.com/books/pdfview/book/4054 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-1051-4 10.3390/books978-3-0365-1051-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036510507 9783036510514 184 Basel, Switzerland open access |
| spellingShingle | serum half-life extension fatty acid conjugation FcRn-mediated recycling serum albumin translocator protein (TSPO) CoCl2 mitochondrial membrane potential reactive oxygen species (ROS) cell viability cell death lung cancer cell line acetylcholinesterase amyloid beta aggregation neuroprotection molecular docking multi-target drug structure–activity relationship brassicasterol phytosterols HSV Mycobacterium tuberculosis HSV-1 DNA polymerase HSV-1 TK human CDK2 ACE UDP-galactopyranose mutase heat shock protein 70 Hsp70 piperine fluorescence spectroscopy molecular dynamics molecular biophysics GADD45β MKK7 multiple myeloma protein-ligand interaction STD-NMR sigma receptors sigma ligands cancer SIGMAR1 PGRMC1 TMEM97 NCI60 COMPARE analysis membrane lipid-protein interaction lipid signalling kinase regulation phosphatidylinositols molecular docking simulation target identification small-molecule derivatives of salicylanilide drug discovery drug development thyroid diseases endocrine disruptor compound human umbilical artery vascular homeostasis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry Protein-Ligand Interactions: Target Identification and Drug Discovery |
| title | Protein-Ligand Interactions: Target Identification and Drug Discovery |
| title_full | Protein-Ligand Interactions: Target Identification and Drug Discovery |
| title_fullStr | Protein-Ligand Interactions: Target Identification and Drug Discovery |
| title_full_unstemmed | Protein-Ligand Interactions: Target Identification and Drug Discovery |
| title_short | Protein-Ligand Interactions: Target Identification and Drug Discovery |
| title_sort | protein ligand interactions target identification and drug discovery |
| topic | serum half-life extension fatty acid conjugation FcRn-mediated recycling serum albumin translocator protein (TSPO) CoCl2 mitochondrial membrane potential reactive oxygen species (ROS) cell viability cell death lung cancer cell line acetylcholinesterase amyloid beta aggregation neuroprotection molecular docking multi-target drug structure–activity relationship brassicasterol phytosterols HSV Mycobacterium tuberculosis HSV-1 DNA polymerase HSV-1 TK human CDK2 ACE UDP-galactopyranose mutase heat shock protein 70 Hsp70 piperine fluorescence spectroscopy molecular dynamics molecular biophysics GADD45β MKK7 multiple myeloma protein-ligand interaction STD-NMR sigma receptors sigma ligands cancer SIGMAR1 PGRMC1 TMEM97 NCI60 COMPARE analysis membrane lipid-protein interaction lipid signalling kinase regulation phosphatidylinositols molecular docking simulation target identification small-molecule derivatives of salicylanilide drug discovery drug development thyroid diseases endocrine disruptor compound human umbilical artery vascular homeostasis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry |
| topic_facet | serum half-life extension fatty acid conjugation FcRn-mediated recycling serum albumin translocator protein (TSPO) CoCl2 mitochondrial membrane potential reactive oxygen species (ROS) cell viability cell death lung cancer cell line acetylcholinesterase amyloid beta aggregation neuroprotection molecular docking multi-target drug structure–activity relationship brassicasterol phytosterols HSV Mycobacterium tuberculosis HSV-1 DNA polymerase HSV-1 TK human CDK2 ACE UDP-galactopyranose mutase heat shock protein 70 Hsp70 piperine fluorescence spectroscopy molecular dynamics molecular biophysics GADD45β MKK7 multiple myeloma protein-ligand interaction STD-NMR sigma receptors sigma ligands cancer SIGMAR1 PGRMC1 TMEM97 NCI60 COMPARE analysis membrane lipid-protein interaction lipid signalling kinase regulation phosphatidylinositols molecular docking simulation target identification small-molecule derivatives of salicylanilide drug discovery drug development thyroid diseases endocrine disruptor compound human umbilical artery vascular homeostasis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry |
| url | ONIX_20220111_9783036510507_344 |