Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances
Marine natural products are characterized by high chemical diversity, biochemical specificity, and other molecular properties that make them favorable as lead structures for drug discovery. In this field, one of the main problems is often the reduced natural availability of isolated substances, whic...
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| Format: | Online |
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| Jezik: | engleski |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Teme: | |
| Online pristup: | ONIX_20220111_9783036517681_406 |
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| _version_ | 1869518029033832448 |
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| collection | Directory of Open Access Books |
| description | Marine natural products are characterized by high chemical diversity, biochemical specificity, and other molecular properties that make them favorable as lead structures for drug discovery. In this field, one of the main problems is often the reduced natural availability of isolated substances, which can complicate both the structural characterization and possible future developments. For these reasons, the study of bioactive marine metabolites should rely on the development of chemical synthesis and synthetic strategies aimed at the preparation of pure compounds and analogs both for structural confirmation and/or for the large-scale preparation necessary for future applications. Moreover, natural products can be a crucial starting point for the preparation of molecules structurally inspired by the latter, opening the path to new classes of biologically active compounds with pharmacological potential. This book collects original research articles regarding synthetic strategies for secondary marine metabolites and/or analogs that favor applications of these molecules and/or solve structural challenges common in the field of natural substances. |
| format | Online |
| id | doab-20.500.12854ir-76671 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-766712024-03-24T11:40:07Z Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances Manzo, Emiliano organic synthesis meroterpenoids thiazinoquinones antiproliferative activity G0/G1 cell-cycle arrest cytostatic solid tumor cell lines alkylglycerol (AKG) ricinoleic acid (RA) antimicrobial activity structure–activity relationship (SAR) studies antibiotics (gentamicin tetracycline ciprofloxacin and ampicillin) marine-inspired breast cancer bis-indoles synthesis apoptosis carbohydrates polysaccharides semi-synthesis sulfation glycosylation fucose fucosylated chondroitin sulfate marine natural product largazole HDAC inhibitors modification fluoro olefin total synthesis natural product 7-deazapurine nucleoside disaccharide nucleoside tubercidin aureol tetracyclic meroterpenoids natural products synthesis labdane scaffold bioactive diterpenes sclareolide structure-activity relationships TRPV4 channel amides/esters COVID-19 SARS-CoV-2 lipophilic iminosugars polymer-supported triphenyl phosphine cholesterol antibacterial iminosugars n/a thema EDItEUR::C Language and Linguistics Marine natural products are characterized by high chemical diversity, biochemical specificity, and other molecular properties that make them favorable as lead structures for drug discovery. In this field, one of the main problems is often the reduced natural availability of isolated substances, which can complicate both the structural characterization and possible future developments. For these reasons, the study of bioactive marine metabolites should rely on the development of chemical synthesis and synthetic strategies aimed at the preparation of pure compounds and analogs both for structural confirmation and/or for the large-scale preparation necessary for future applications. Moreover, natural products can be a crucial starting point for the preparation of molecules structurally inspired by the latter, opening the path to new classes of biologically active compounds with pharmacological potential. This book collects original research articles regarding synthetic strategies for secondary marine metabolites and/or analogs that favor applications of these molecules and/or solve structural challenges common in the field of natural substances. 2022-01-11T13:38:35Z 2022-01-11T13:38:35Z 2021 book ONIX_20220111_9783036517681_406 9783036517681 9783036517674 https://directory.doabooks.org/handle/20.500.12854/76671 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4118 https://mdpi.com/books/pdfview/book/4118 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-1767-4 10.3390/books978-3-0365-1767-4 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036517681 9783036517674 147 Basel, Switzerland open access |
| spellingShingle | organic synthesis meroterpenoids thiazinoquinones antiproliferative activity G0/G1 cell-cycle arrest cytostatic solid tumor cell lines alkylglycerol (AKG) ricinoleic acid (RA) antimicrobial activity structure–activity relationship (SAR) studies antibiotics (gentamicin tetracycline ciprofloxacin and ampicillin) marine-inspired breast cancer bis-indoles synthesis apoptosis carbohydrates polysaccharides semi-synthesis sulfation glycosylation fucose fucosylated chondroitin sulfate marine natural product largazole HDAC inhibitors modification fluoro olefin total synthesis natural product 7-deazapurine nucleoside disaccharide nucleoside tubercidin aureol tetracyclic meroterpenoids natural products synthesis labdane scaffold bioactive diterpenes sclareolide structure-activity relationships TRPV4 channel amides/esters COVID-19 SARS-CoV-2 lipophilic iminosugars polymer-supported triphenyl phosphine cholesterol antibacterial iminosugars n/a thema EDItEUR::C Language and Linguistics Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances |
| title | Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances |
| title_full | Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances |
| title_fullStr | Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances |
| title_full_unstemmed | Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances |
| title_short | Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances |
| title_sort | synthesis of marine natural products and molecules inspired by marine substances |
| topic | organic synthesis meroterpenoids thiazinoquinones antiproliferative activity G0/G1 cell-cycle arrest cytostatic solid tumor cell lines alkylglycerol (AKG) ricinoleic acid (RA) antimicrobial activity structure–activity relationship (SAR) studies antibiotics (gentamicin tetracycline ciprofloxacin and ampicillin) marine-inspired breast cancer bis-indoles synthesis apoptosis carbohydrates polysaccharides semi-synthesis sulfation glycosylation fucose fucosylated chondroitin sulfate marine natural product largazole HDAC inhibitors modification fluoro olefin total synthesis natural product 7-deazapurine nucleoside disaccharide nucleoside tubercidin aureol tetracyclic meroterpenoids natural products synthesis labdane scaffold bioactive diterpenes sclareolide structure-activity relationships TRPV4 channel amides/esters COVID-19 SARS-CoV-2 lipophilic iminosugars polymer-supported triphenyl phosphine cholesterol antibacterial iminosugars n/a thema EDItEUR::C Language and Linguistics |
| topic_facet | organic synthesis meroterpenoids thiazinoquinones antiproliferative activity G0/G1 cell-cycle arrest cytostatic solid tumor cell lines alkylglycerol (AKG) ricinoleic acid (RA) antimicrobial activity structure–activity relationship (SAR) studies antibiotics (gentamicin tetracycline ciprofloxacin and ampicillin) marine-inspired breast cancer bis-indoles synthesis apoptosis carbohydrates polysaccharides semi-synthesis sulfation glycosylation fucose fucosylated chondroitin sulfate marine natural product largazole HDAC inhibitors modification fluoro olefin total synthesis natural product 7-deazapurine nucleoside disaccharide nucleoside tubercidin aureol tetracyclic meroterpenoids natural products synthesis labdane scaffold bioactive diterpenes sclareolide structure-activity relationships TRPV4 channel amides/esters COVID-19 SARS-CoV-2 lipophilic iminosugars polymer-supported triphenyl phosphine cholesterol antibacterial iminosugars n/a thema EDItEUR::C Language and Linguistics |
| url | ONIX_20220111_9783036517681_406 |