Multimodal Therapy of Upper Gastrointestinal Malignancies
Recent decades have seen remarkable advances in the treatment of upper gastrointestinal malignancies, i.e., adenocarcinoma and squamous cell carcinoma as well as gastrointestinal stromal and other rare tumors of the esophagus and stomach. While, historically, surgical resection has been the sole tre...
में बचाया:
| स्वरूप: | Online |
|---|---|
| भाषा: | अंग्रेज़ी |
| प्रकाशित: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| विषय: | |
| ऑनलाइन पहुंच: | ONIX_20220111_9783036509204_533 |
| टैग: |
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!
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| _version_ | 1869521736267988992 |
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| collection | Directory of Open Access Books |
| description | Recent decades have seen remarkable advances in the treatment of upper gastrointestinal malignancies, i.e., adenocarcinoma and squamous cell carcinoma as well as gastrointestinal stromal and other rare tumors of the esophagus and stomach. While, historically, surgical resection has been the sole treatment for these tumors, multimodal therapies have meanwhile proven their efficacy. At present, pre- and postoperative chemotherapy and radiotherapy, targeted drug therapy, and stage-specific surgical approaches are all indispensable cornerstones of an individualized treatment for upper gastrointestinal malignancies. With such multimodal treatment, better outcomes comprising improved quality of life and prolonged survival have been achieved for patients. However, for many tumor entities and stages, the ideal combination and sequence of treatments is still being evaluated in clinical trials. Moreover, the value of novel approaches such as immunotherapy or robotic surgery remains a matter of research. In this Special Issue of Cancers, up-to-date original research, short communications, and comprehensive review articles on all modalities playing a role in the treatment of upper gastrointestinal malignancies have been published. |
| format | Online |
| id | doab-20.500.12854ir-76798 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-767982024-03-31T13:09:02Z Multimodal Therapy of Upper Gastrointestinal Malignancies Ronellenfitsch, Ulrich gastric cancer gastrectomy complications outcome survival lymph node ratio neoadjuvant chemotherapy conversion surgery cancer dormancy nuclear receptor NR2F1 clinical pathways gastric surgery oncological gastrectomy quality of care outcomes standardization adjuvant therapy gastrointestinal tract genetic diagnosis radiosensitivity mortality failure to rescue immunotherapy genetics esophageal cancer multidisciplinary gastric/gastroesophageal cancer perioperative chemotherapy overall survival relapse-free survival skeletal muscle index esophagectomy nutritional status sarcopenia esophageal anastomosis minimally invasive surgery induction chemotherapy chemo-radiotherapy neoadjuvant treatment esophageal squamous cell carcinoma multimodal treatment neoadjuvant chemoradiotherapy definitive chemoradiotherapy Lauren histotype gastrointestinal stromal tumor neuroendocrine tumor MALT lymphoma mucosal resection submucosal dissection GIST stomach neoadjuvant therapy imatinib organ preservation squamous cell esophageal cancer gastro-esophageal reflux disease Barrett’s esophagus early adenocarcinoma of esophagus endoscopic submucosal dissection endoscopic mucosal resection n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine Recent decades have seen remarkable advances in the treatment of upper gastrointestinal malignancies, i.e., adenocarcinoma and squamous cell carcinoma as well as gastrointestinal stromal and other rare tumors of the esophagus and stomach. While, historically, surgical resection has been the sole treatment for these tumors, multimodal therapies have meanwhile proven their efficacy. At present, pre- and postoperative chemotherapy and radiotherapy, targeted drug therapy, and stage-specific surgical approaches are all indispensable cornerstones of an individualized treatment for upper gastrointestinal malignancies. With such multimodal treatment, better outcomes comprising improved quality of life and prolonged survival have been achieved for patients. However, for many tumor entities and stages, the ideal combination and sequence of treatments is still being evaluated in clinical trials. Moreover, the value of novel approaches such as immunotherapy or robotic surgery remains a matter of research. In this Special Issue of Cancers, up-to-date original research, short communications, and comprehensive review articles on all modalities playing a role in the treatment of upper gastrointestinal malignancies have been published. 2022-01-11T13:42:33Z 2022-01-11T13:42:33Z 2021 book ONIX_20220111_9783036509204_533 9783036509204 9783036509211 https://directory.doabooks.org/handle/20.500.12854/76798 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4247 https://mdpi.com/books/pdfview/book/4247 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-0921-1 10.3390/books978-3-0365-0921-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036509204 9783036509211 272 Basel, Switzerland open access |
| spellingShingle | gastric cancer gastrectomy complications outcome survival lymph node ratio neoadjuvant chemotherapy conversion surgery cancer dormancy nuclear receptor NR2F1 clinical pathways gastric surgery oncological gastrectomy quality of care outcomes standardization adjuvant therapy gastrointestinal tract genetic diagnosis radiosensitivity mortality failure to rescue immunotherapy genetics esophageal cancer multidisciplinary gastric/gastroesophageal cancer perioperative chemotherapy overall survival relapse-free survival skeletal muscle index esophagectomy nutritional status sarcopenia esophageal anastomosis minimally invasive surgery induction chemotherapy chemo-radiotherapy neoadjuvant treatment esophageal squamous cell carcinoma multimodal treatment neoadjuvant chemoradiotherapy definitive chemoradiotherapy Lauren histotype gastrointestinal stromal tumor neuroendocrine tumor MALT lymphoma mucosal resection submucosal dissection GIST stomach neoadjuvant therapy imatinib organ preservation squamous cell esophageal cancer gastro-esophageal reflux disease Barrett’s esophagus early adenocarcinoma of esophagus endoscopic submucosal dissection endoscopic mucosal resection n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine Multimodal Therapy of Upper Gastrointestinal Malignancies |
| title | Multimodal Therapy of Upper Gastrointestinal Malignancies |
| title_full | Multimodal Therapy of Upper Gastrointestinal Malignancies |
| title_fullStr | Multimodal Therapy of Upper Gastrointestinal Malignancies |
| title_full_unstemmed | Multimodal Therapy of Upper Gastrointestinal Malignancies |
| title_short | Multimodal Therapy of Upper Gastrointestinal Malignancies |
| title_sort | multimodal therapy of upper gastrointestinal malignancies |
| topic | gastric cancer gastrectomy complications outcome survival lymph node ratio neoadjuvant chemotherapy conversion surgery cancer dormancy nuclear receptor NR2F1 clinical pathways gastric surgery oncological gastrectomy quality of care outcomes standardization adjuvant therapy gastrointestinal tract genetic diagnosis radiosensitivity mortality failure to rescue immunotherapy genetics esophageal cancer multidisciplinary gastric/gastroesophageal cancer perioperative chemotherapy overall survival relapse-free survival skeletal muscle index esophagectomy nutritional status sarcopenia esophageal anastomosis minimally invasive surgery induction chemotherapy chemo-radiotherapy neoadjuvant treatment esophageal squamous cell carcinoma multimodal treatment neoadjuvant chemoradiotherapy definitive chemoradiotherapy Lauren histotype gastrointestinal stromal tumor neuroendocrine tumor MALT lymphoma mucosal resection submucosal dissection GIST stomach neoadjuvant therapy imatinib organ preservation squamous cell esophageal cancer gastro-esophageal reflux disease Barrett’s esophagus early adenocarcinoma of esophagus endoscopic submucosal dissection endoscopic mucosal resection n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine |
| topic_facet | gastric cancer gastrectomy complications outcome survival lymph node ratio neoadjuvant chemotherapy conversion surgery cancer dormancy nuclear receptor NR2F1 clinical pathways gastric surgery oncological gastrectomy quality of care outcomes standardization adjuvant therapy gastrointestinal tract genetic diagnosis radiosensitivity mortality failure to rescue immunotherapy genetics esophageal cancer multidisciplinary gastric/gastroesophageal cancer perioperative chemotherapy overall survival relapse-free survival skeletal muscle index esophagectomy nutritional status sarcopenia esophageal anastomosis minimally invasive surgery induction chemotherapy chemo-radiotherapy neoadjuvant treatment esophageal squamous cell carcinoma multimodal treatment neoadjuvant chemoradiotherapy definitive chemoradiotherapy Lauren histotype gastrointestinal stromal tumor neuroendocrine tumor MALT lymphoma mucosal resection submucosal dissection GIST stomach neoadjuvant therapy imatinib organ preservation squamous cell esophageal cancer gastro-esophageal reflux disease Barrett’s esophagus early adenocarcinoma of esophagus endoscopic submucosal dissection endoscopic mucosal resection n/a thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine |
| url | ONIX_20220111_9783036509204_533 |