Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics
The sense of hearing is vulnerable to environmental challenges, such as exposure to noise. More than 1.5 billion people experience some decline in hearing ability during their lifetime, of whom at least 430 million will be affected by disabling hearing loss. If not identified and addressed in a time...
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| Μορφή: | Online |
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| Γλώσσα: | Αγγλικά |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Διαθέσιμο Online: | ONIX_20220111_9783036515069_575 |
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| _version_ | 1869531298204221440 |
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| collection | Directory of Open Access Books |
| description | The sense of hearing is vulnerable to environmental challenges, such as exposure to noise. More than 1.5 billion people experience some decline in hearing ability during their lifetime, of whom at least 430 million will be affected by disabling hearing loss. If not identified and addressed in a timely way, hearing loss can severely reduce the quality of life at various stages. Some causes of hearing loss can be prevented, for example from occupational or leisure noise. The World Health Organization estimates that more than 1 billion young people put themselves at risk of permanent hearing loss by listening to loud music over long periods of time. Mitigating such risks through public health action is essential to reduce the impact of hearing loss in the community. The etiology of sensorineural hearing loss is complex and multifactorial, arising from congenital and acquired causes. This book highlights the diverse range of approaches to sensorineural hearing loss, from designing new animal models of age-related hearing loss, to the use of microRNAs as biomarkers of cochlear injury and drug repurposing for the therapy of age-related and noise-induced hearing loss. Further investigation into the underlying molecular mechanisms of sensorineural hearing loss and the integration of the novel drug, cell, and gene therapy strategies into controlled clinical studies will permit significant advances in a field where there are currently many unmet needs. |
| format | Online |
| id | doab-20.500.12854ir-76840 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-768402024-03-31T13:10:20Z Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics Vlajkovic, Srdjan M brain-derived neurotrophic factor TrkB inner ear development zebrafish mitochondria dysfunction reactive oxygen species hypoxic d-galactose high-fat diet aging hearing loss astrocytes auditory brainstem lateral superior olive gap junctions voltage-activated calcium channel 1.3 otoferlin spontaneous activity deafness circadian dysregulation clock genes noise-induced hearing loss sensory hair cells synaptic ribbons sensorineural hearing loss hyperbaric oxygenation adjunctive therapy microRNAs cochlear nucleus inferior colliculus neuroplasticity noise-induced cochlear injury cochlear rescue otoprotection adenosine A1 receptor regulator of G protein signalling 4 CCG-4986 intratympanic drug delivery potassium voltage-gated channel subfamily q member 4 potassium nonsyndromic hearing loss KCNQ4 activator age-related hearing loss selegiline chronic oral treatment hearing protection mouse model n/a thema EDItEUR::M Medicine and Nursing The sense of hearing is vulnerable to environmental challenges, such as exposure to noise. More than 1.5 billion people experience some decline in hearing ability during their lifetime, of whom at least 430 million will be affected by disabling hearing loss. If not identified and addressed in a timely way, hearing loss can severely reduce the quality of life at various stages. Some causes of hearing loss can be prevented, for example from occupational or leisure noise. The World Health Organization estimates that more than 1 billion young people put themselves at risk of permanent hearing loss by listening to loud music over long periods of time. Mitigating such risks through public health action is essential to reduce the impact of hearing loss in the community. The etiology of sensorineural hearing loss is complex and multifactorial, arising from congenital and acquired causes. This book highlights the diverse range of approaches to sensorineural hearing loss, from designing new animal models of age-related hearing loss, to the use of microRNAs as biomarkers of cochlear injury and drug repurposing for the therapy of age-related and noise-induced hearing loss. Further investigation into the underlying molecular mechanisms of sensorineural hearing loss and the integration of the novel drug, cell, and gene therapy strategies into controlled clinical studies will permit significant advances in a field where there are currently many unmet needs. 2022-01-11T13:43:47Z 2022-01-11T13:43:47Z 2021 book ONIX_20220111_9783036515069_575 9783036515069 9783036515052 https://directory.doabooks.org/handle/20.500.12854/76840 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4289 https://mdpi.com/books/pdfview/book/4289 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-1505-2 10.3390/books978-3-0365-1505-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036515069 9783036515052 5793 Basel, Switzerland open access |
| spellingShingle | brain-derived neurotrophic factor TrkB inner ear development zebrafish mitochondria dysfunction reactive oxygen species hypoxic d-galactose high-fat diet aging hearing loss astrocytes auditory brainstem lateral superior olive gap junctions voltage-activated calcium channel 1.3 otoferlin spontaneous activity deafness circadian dysregulation clock genes noise-induced hearing loss sensory hair cells synaptic ribbons sensorineural hearing loss hyperbaric oxygenation adjunctive therapy microRNAs cochlear nucleus inferior colliculus neuroplasticity noise-induced cochlear injury cochlear rescue otoprotection adenosine A1 receptor regulator of G protein signalling 4 CCG-4986 intratympanic drug delivery potassium voltage-gated channel subfamily q member 4 potassium nonsyndromic hearing loss KCNQ4 activator age-related hearing loss selegiline chronic oral treatment hearing protection mouse model n/a thema EDItEUR::M Medicine and Nursing Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics |
| title | Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics |
| title_full | Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics |
| title_fullStr | Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics |
| title_full_unstemmed | Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics |
| title_short | Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics |
| title_sort | molecular mechanisms of sensorineural hearing loss and development of inner ear therapeutics |
| topic | brain-derived neurotrophic factor TrkB inner ear development zebrafish mitochondria dysfunction reactive oxygen species hypoxic d-galactose high-fat diet aging hearing loss astrocytes auditory brainstem lateral superior olive gap junctions voltage-activated calcium channel 1.3 otoferlin spontaneous activity deafness circadian dysregulation clock genes noise-induced hearing loss sensory hair cells synaptic ribbons sensorineural hearing loss hyperbaric oxygenation adjunctive therapy microRNAs cochlear nucleus inferior colliculus neuroplasticity noise-induced cochlear injury cochlear rescue otoprotection adenosine A1 receptor regulator of G protein signalling 4 CCG-4986 intratympanic drug delivery potassium voltage-gated channel subfamily q member 4 potassium nonsyndromic hearing loss KCNQ4 activator age-related hearing loss selegiline chronic oral treatment hearing protection mouse model n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | brain-derived neurotrophic factor TrkB inner ear development zebrafish mitochondria dysfunction reactive oxygen species hypoxic d-galactose high-fat diet aging hearing loss astrocytes auditory brainstem lateral superior olive gap junctions voltage-activated calcium channel 1.3 otoferlin spontaneous activity deafness circadian dysregulation clock genes noise-induced hearing loss sensory hair cells synaptic ribbons sensorineural hearing loss hyperbaric oxygenation adjunctive therapy microRNAs cochlear nucleus inferior colliculus neuroplasticity noise-induced cochlear injury cochlear rescue otoprotection adenosine A1 receptor regulator of G protein signalling 4 CCG-4986 intratympanic drug delivery potassium voltage-gated channel subfamily q member 4 potassium nonsyndromic hearing loss KCNQ4 activator age-related hearing loss selegiline chronic oral treatment hearing protection mouse model n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20220111_9783036515069_575 |