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Cellular Senescence in Health, Disease and Aging: Blessing or Curse?

Dear Colleagues, When Hayflick and Moorhead coined the term “cellular senescence” (CS) almost 60 years ago, this phenomenon was understood as a mechanism, usually induced by activation of the DNA-repair machinery, to prevent uncontrolled proliferation. Meanwhile, additional beneficial roles for CS h...

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Médium: Online
Jazyk:angličtina
Vydáno: MDPI - Multidisciplinary Digital Publishing Institute 2022
Témata:
γH2AX
Alzheimer’s disease
DNA damage
mild cognitive impairment
senescence
secreted protein acidic and rich in cysteine
regeneration
homeostasis
cellular senescence
biology of aging
neurodegeneration
brain
geroscience
senolytics
tauopathy
cancer
stress response
post-mitotic
neuronal senescence
amyotrophic lateral sclerosis
senescence-associated secretory phenotype (SASP)
cell-cycle
melanoma
pancreatic adenocarcinoma
tumor infiltration
chemotherapy resistance
prostate
inflammation
AIM2 inflammasome
POP3
n/a
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
On-line přístup:ONIX_20220111_9783036521756_774
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ONIX_20220111_9783036521756_774

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