Mitochondria: From Physiology to Pathology
Mitochondria play an increasingly central role in the context of cellular physiology. These organelles possess their own genome (mtDNA), which is functionally coordinated with the nuclear genome. Mitochondrial gene expression is mediated by molecular processes (replication, transcription, translatio...
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| Formato: | Online |
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| Idioma: | inglês |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Acesso em linha: | ONIX_20220111_9783036521510_786 |
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| description | Mitochondria play an increasingly central role in the context of cellular physiology. These organelles possess their own genome (mtDNA), which is functionally coordinated with the nuclear genome. Mitochondrial gene expression is mediated by molecular processes (replication, transcription, translation, and assembly of respiratory chain complexes) that all take place within the mitochondria. Several aspects of mtDNA expression have already been well characterized, but many more either are under debate or have yet to be discovered. Understanding the molecular processes occurring in mitochondria also has clinical relevance. Dysfunctions affecting these important metabolic ‘hubs’ are associated with a whole range of severe disorders, known as mitochondrial diseases. In recent years, significant progress has been made to understand the pathogenic mechanisms underlying mitochondrial dysfunction; however, to date, mitochondrial diseases are complex genetic disorders without any effective therapy. Current therapeutic strategies and clinical trials are aimed at mitigating clinical manifestations and slowing the disease progression to improve the quality of life of patients. The goal of the Special Issue ‘Mitochondria: from Physiology to Pathology’ published in Life (ISSN: 2075-1729) was to collect research and review articles covering the physiological and pathological aspects related to mtDNA maintenance and gene expression, mitochondrial biogenesis, protein import, organelle metabolism, and quality control. |
| format | Online |
| id | doab-20.500.12854ir-76954 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-769542024-03-27T16:34:34Z Mitochondria: From Physiology to Pathology Bruni, Francesco atherosclerosis carotid intima-media thickness mitochondrial mutations cardiovascular risk factors mitochondria mtDNA cristae mitochondrial fission mitochondrial fusion mitochondrial diseas mitochondrial dynamics mitoenergetics mitosteroidogenesis LH cAMP Leydig cell mitochondrial DNA segregation heteroplasmy selective elimination mitophagy mitochondrial engineered nucleases kinases phosphorylation disease PINK1 Parkinson’s disease mitochondria homeostasis Cterm MELAS transmitochondrial cybrids aminoacyl-tRNA synthetases LARS2 mitochondrial disease therapeutic peptides FAD synthase FAD1 mitochondria localization Saccharomyces cerevisiae mRNA mitochondrial localization motif n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general Mitochondria play an increasingly central role in the context of cellular physiology. These organelles possess their own genome (mtDNA), which is functionally coordinated with the nuclear genome. Mitochondrial gene expression is mediated by molecular processes (replication, transcription, translation, and assembly of respiratory chain complexes) that all take place within the mitochondria. Several aspects of mtDNA expression have already been well characterized, but many more either are under debate or have yet to be discovered. Understanding the molecular processes occurring in mitochondria also has clinical relevance. Dysfunctions affecting these important metabolic ‘hubs’ are associated with a whole range of severe disorders, known as mitochondrial diseases. In recent years, significant progress has been made to understand the pathogenic mechanisms underlying mitochondrial dysfunction; however, to date, mitochondrial diseases are complex genetic disorders without any effective therapy. Current therapeutic strategies and clinical trials are aimed at mitigating clinical manifestations and slowing the disease progression to improve the quality of life of patients. The goal of the Special Issue ‘Mitochondria: from Physiology to Pathology’ published in Life (ISSN: 2075-1729) was to collect research and review articles covering the physiological and pathological aspects related to mtDNA maintenance and gene expression, mitochondrial biogenesis, protein import, organelle metabolism, and quality control. 2022-01-11T13:47:31Z 2022-01-11T13:47:31Z 2021 book ONIX_20220111_9783036521510_786 9783036521510 9783036521527 https://directory.doabooks.org/handle/20.500.12854/76954 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4545 https://mdpi.com/books/pdfview/book/4545 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-2152-7 10.3390/books978-3-0365-2152-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036521510 9783036521527 196 Basel, Switzerland open access |
| spellingShingle | atherosclerosis carotid intima-media thickness mitochondrial mutations cardiovascular risk factors mitochondria mtDNA cristae mitochondrial fission mitochondrial fusion mitochondrial diseas mitochondrial dynamics mitoenergetics mitosteroidogenesis LH cAMP Leydig cell mitochondrial DNA segregation heteroplasmy selective elimination mitophagy mitochondrial engineered nucleases kinases phosphorylation disease PINK1 Parkinson’s disease mitochondria homeostasis Cterm MELAS transmitochondrial cybrids aminoacyl-tRNA synthetases LARS2 mitochondrial disease therapeutic peptides FAD synthase FAD1 mitochondria localization Saccharomyces cerevisiae mRNA mitochondrial localization motif n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general Mitochondria: From Physiology to Pathology |
| title | Mitochondria: From Physiology to Pathology |
| title_full | Mitochondria: From Physiology to Pathology |
| title_fullStr | Mitochondria: From Physiology to Pathology |
| title_full_unstemmed | Mitochondria: From Physiology to Pathology |
| title_short | Mitochondria: From Physiology to Pathology |
| title_sort | mitochondria from physiology to pathology |
| topic | atherosclerosis carotid intima-media thickness mitochondrial mutations cardiovascular risk factors mitochondria mtDNA cristae mitochondrial fission mitochondrial fusion mitochondrial diseas mitochondrial dynamics mitoenergetics mitosteroidogenesis LH cAMP Leydig cell mitochondrial DNA segregation heteroplasmy selective elimination mitophagy mitochondrial engineered nucleases kinases phosphorylation disease PINK1 Parkinson’s disease mitochondria homeostasis Cterm MELAS transmitochondrial cybrids aminoacyl-tRNA synthetases LARS2 mitochondrial disease therapeutic peptides FAD synthase FAD1 mitochondria localization Saccharomyces cerevisiae mRNA mitochondrial localization motif n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general |
| topic_facet | atherosclerosis carotid intima-media thickness mitochondrial mutations cardiovascular risk factors mitochondria mtDNA cristae mitochondrial fission mitochondrial fusion mitochondrial diseas mitochondrial dynamics mitoenergetics mitosteroidogenesis LH cAMP Leydig cell mitochondrial DNA segregation heteroplasmy selective elimination mitophagy mitochondrial engineered nucleases kinases phosphorylation disease PINK1 Parkinson’s disease mitochondria homeostasis Cterm MELAS transmitochondrial cybrids aminoacyl-tRNA synthetases LARS2 mitochondrial disease therapeutic peptides FAD synthase FAD1 mitochondria localization Saccharomyces cerevisiae mRNA mitochondrial localization motif n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general |
| url | ONIX_20220111_9783036521510_786 |