Drug Absorption Studies: In Situ, In Vitro and In Silico Models
This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorpt...
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| Materyal Türü: | Online |
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| Dil: | İngilizce |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Konular: | |
| Online Erişim: | ONIX_20220111_9783036524610_903 |
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| _version_ | 1869524983102832640 |
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| collection | Directory of Open Access Books |
| description | This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorption studies and related technologies that predict intestinal permeation of drugs that govern the pharmacokinetic features of therapeutic drugs. It also contains the mechanistic understanding regarding the first-pass metabolism and intestinal efflux that modulate the pharmacokinetics of drug and suggest the formulation strategies to enhance the bioavailability of investigated drugs. |
| format | Online |
| id | doab-20.500.12854ir-77071 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-770712024-03-31T13:10:25Z Drug Absorption Studies: In Situ, In Vitro and In Silico Models Song, Im-Sook rebamipide nanocrystals oral mucositis hydrogel endocytosis enoxaparin lipid–polymer hybrid nanoparticles oral intestinal absorption naftidrofuryl oxalate solubility permeability dissolution profiles pharmaceutical availability BCS drug classification non-sink condition solubility–permeability interplay unstirred water layer poorly soluble drugs solubilizer additive phenylketonuria l-phenylalanine ammonia-lyase enzyme kinetics catabolism disorder biomedical drug P-glycoprotein breast cancer resistance protein LY335979 WK-X-34 in vivo–in vitro correlation lipolysis-permeation lipid-based drug delivery system PermeaPad cinnarizine lipolysis amorphous solid dispersion candesartan Cilexetil PVPK30 pH-modulation spray drying bioavailability nasal administration spray-drying chitosan microsphere meloxicam silymarin D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) liver distribution acetaminophen-induced hepatotoxicity extra virgin olive oil secoiridoids metabolism phenolic compounds intestinal permeability drug-phytochemical interaction hepatic metabolism mixed inhibition quercetin repaglinide thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorption studies and related technologies that predict intestinal permeation of drugs that govern the pharmacokinetic features of therapeutic drugs. It also contains the mechanistic understanding regarding the first-pass metabolism and intestinal efflux that modulate the pharmacokinetics of drug and suggest the formulation strategies to enhance the bioavailability of investigated drugs. 2022-01-11T13:51:18Z 2022-01-11T13:51:18Z 2021 book ONIX_20220111_9783036524610_903 9783036524610 9783036524603 https://directory.doabooks.org/handle/20.500.12854/77071 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4689 https://mdpi.com/books/pdfview/book/4689 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-2460-3 10.3390/books978-3-0365-2460-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036524610 9783036524603 171 Basel, Switzerland open access |
| spellingShingle | rebamipide nanocrystals oral mucositis hydrogel endocytosis enoxaparin lipid–polymer hybrid nanoparticles oral intestinal absorption naftidrofuryl oxalate solubility permeability dissolution profiles pharmaceutical availability BCS drug classification non-sink condition solubility–permeability interplay unstirred water layer poorly soluble drugs solubilizer additive phenylketonuria l-phenylalanine ammonia-lyase enzyme kinetics catabolism disorder biomedical drug P-glycoprotein breast cancer resistance protein LY335979 WK-X-34 in vivo–in vitro correlation lipolysis-permeation lipid-based drug delivery system PermeaPad cinnarizine lipolysis amorphous solid dispersion candesartan Cilexetil PVPK30 pH-modulation spray drying bioavailability nasal administration spray-drying chitosan microsphere meloxicam silymarin D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) liver distribution acetaminophen-induced hepatotoxicity extra virgin olive oil secoiridoids metabolism phenolic compounds intestinal permeability drug-phytochemical interaction hepatic metabolism mixed inhibition quercetin repaglinide thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| title | Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| title_full | Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| title_fullStr | Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| title_full_unstemmed | Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| title_short | Drug Absorption Studies: In Situ, In Vitro and In Silico Models |
| title_sort | drug absorption studies in situ in vitro and in silico models |
| topic | rebamipide nanocrystals oral mucositis hydrogel endocytosis enoxaparin lipid–polymer hybrid nanoparticles oral intestinal absorption naftidrofuryl oxalate solubility permeability dissolution profiles pharmaceutical availability BCS drug classification non-sink condition solubility–permeability interplay unstirred water layer poorly soluble drugs solubilizer additive phenylketonuria l-phenylalanine ammonia-lyase enzyme kinetics catabolism disorder biomedical drug P-glycoprotein breast cancer resistance protein LY335979 WK-X-34 in vivo–in vitro correlation lipolysis-permeation lipid-based drug delivery system PermeaPad cinnarizine lipolysis amorphous solid dispersion candesartan Cilexetil PVPK30 pH-modulation spray drying bioavailability nasal administration spray-drying chitosan microsphere meloxicam silymarin D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) liver distribution acetaminophen-induced hepatotoxicity extra virgin olive oil secoiridoids metabolism phenolic compounds intestinal permeability drug-phytochemical interaction hepatic metabolism mixed inhibition quercetin repaglinide thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| topic_facet | rebamipide nanocrystals oral mucositis hydrogel endocytosis enoxaparin lipid–polymer hybrid nanoparticles oral intestinal absorption naftidrofuryl oxalate solubility permeability dissolution profiles pharmaceutical availability BCS drug classification non-sink condition solubility–permeability interplay unstirred water layer poorly soluble drugs solubilizer additive phenylketonuria l-phenylalanine ammonia-lyase enzyme kinetics catabolism disorder biomedical drug P-glycoprotein breast cancer resistance protein LY335979 WK-X-34 in vivo–in vitro correlation lipolysis-permeation lipid-based drug delivery system PermeaPad cinnarizine lipolysis amorphous solid dispersion candesartan Cilexetil PVPK30 pH-modulation spray drying bioavailability nasal administration spray-drying chitosan microsphere meloxicam silymarin D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) liver distribution acetaminophen-induced hepatotoxicity extra virgin olive oil secoiridoids metabolism phenolic compounds intestinal permeability drug-phytochemical interaction hepatic metabolism mixed inhibition quercetin repaglinide thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| url | ONIX_20220111_9783036524610_903 |