The Retina in Health and Disease
Vision is the most important sense in higher mammals. The retina is the first step in visual processing and the window to the brain. It is not surprising that problems arising in the retina lead to moderate to severe visual impairments. We offer here a collection of reviews as well as original paper...
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| Format: | Online |
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| Jezik: | engleski |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Teme: | |
| Online pristup: | ONIX_20220111_9783036526539_958 |
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Bez oznaka, Budi prvi tko označuje ovaj zapis!
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| collection | Directory of Open Access Books |
| description | Vision is the most important sense in higher mammals. The retina is the first step in visual processing and the window to the brain. It is not surprising that problems arising in the retina lead to moderate to severe visual impairments. We offer here a collection of reviews as well as original papers dealing with various aspects of retinal function as well as dysfunction. New approaches in retinal research are described, such as the expression and localization of the endocannabinoid system in the normal retina and the role of cannabinoid receptors that could offer new avenues of research in the development of potential treatments for retinal diseases. Moreover, new insights are offered in advancing knowledge towards the prevention and cure of visual pathologies, mainly AMD, RP, and diabetic retinopathy. |
| format | Online |
| id | doab-20.500.12854ir-77126 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-771262024-03-31T13:08:31Z The Retina in Health and Disease Ptito, Maurice Bouskila, Joseph eye retina development vascularization hypoxia autophagy programmed cell death cellular senescence retinogenesis altricial bird species precocial bird species senescence-associated galactosidase activity diabetes mellitus retinopathy microvascular complication optical coherence tomography angiography black African-American systemic disease biomarker retinal degenerative diseases mesenchymal stem cells stem cell therapy experimental models clinical trials AMD age-related macular degeneration trichostatin A (TSA) HDAC histone deacetylase vascular endothelial growth factor (VEGF) retinal degeneration endoplasmic reticulum stress response unfolded protein response GRP78 retinal glial cell diabetic retinopathy zebrafish neurovascular unit microvascular complications and dysfunction metabolism motor protein myosin 1C photoreceptor rhodopsin outer segments visual function macroglia astrocytes Müller cells optic nerve crush retinal ganglion cells spinal cord injury signal transducer and activator of transcription 3 epidermal growth factor Drp1 apoptosis mitochondria microglia neurodegeneration multiple sclerosis retinal microglia microglia morphotype light damage functional analysis early detection remodeling lactate GPR81 HCAR1 growth cone dLGN axon 3,5-DHBA kallikrein-kinin system kinin receptors GFAP osteopontin retinal detachment diabetes antioxidants bioenergetics respiration ATP glucagon-like peptide-1 exendin-4 catalase immunohistochemistry electron microscopy Charles Bonnet syndrome EEG visual hallucination resting state high-fat diet gut microbiome gut-retina axis RNA sequencing germ-free mice complement cascade angiogenesis retinal inflammation AII amacrine cell Prox1 parvalbumin gap junction eccentricity ON/OFF asymmetry arterioles betulinic acid ischemia-reperfusion injury reactive oxygen species retinal vessels retinal fluorescence imaging amyloid cognitive decline Alzheimer’s disease optic neuritis oxidative stress neuroprotection fingolimod iPSC-RPE retinal pigment epithelium immunodeficient RCS rat ultrathin parylene retinal transplantation CD4+CD25+ inflammation iPSC typical cannabinoid receptors atypical cannabinoid receptors electroretinography monkeys visual system eye inflammation lipopolysaccharide natural bioactive extracts Ac2-26 FPR receptor inflammatory mediators retinal light injury LED screen optical filter retinal protection regeneration progenitor cell hyperglycemia photoreceptors neurod Notch n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Vision is the most important sense in higher mammals. The retina is the first step in visual processing and the window to the brain. It is not surprising that problems arising in the retina lead to moderate to severe visual impairments. We offer here a collection of reviews as well as original papers dealing with various aspects of retinal function as well as dysfunction. New approaches in retinal research are described, such as the expression and localization of the endocannabinoid system in the normal retina and the role of cannabinoid receptors that could offer new avenues of research in the development of potential treatments for retinal diseases. Moreover, new insights are offered in advancing knowledge towards the prevention and cure of visual pathologies, mainly AMD, RP, and diabetic retinopathy. 2022-01-11T13:53:03Z 2022-01-11T13:53:03Z 2021 book ONIX_20220111_9783036526539_958 9783036526539 9783036526522 https://directory.doabooks.org/handle/20.500.12854/77126 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4745 https://mdpi.com/books/pdfview/book/4745 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-2652-2 10.3390/books978-3-0365-2652-2 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036526539 9783036526522 465 Basel, Switzerland open access |
| spellingShingle | eye retina development vascularization hypoxia autophagy programmed cell death cellular senescence retinogenesis altricial bird species precocial bird species senescence-associated galactosidase activity diabetes mellitus retinopathy microvascular complication optical coherence tomography angiography black African-American systemic disease biomarker retinal degenerative diseases mesenchymal stem cells stem cell therapy experimental models clinical trials AMD age-related macular degeneration trichostatin A (TSA) HDAC histone deacetylase vascular endothelial growth factor (VEGF) retinal degeneration endoplasmic reticulum stress response unfolded protein response GRP78 retinal glial cell diabetic retinopathy zebrafish neurovascular unit microvascular complications and dysfunction metabolism motor protein myosin 1C photoreceptor rhodopsin outer segments visual function macroglia astrocytes Müller cells optic nerve crush retinal ganglion cells spinal cord injury signal transducer and activator of transcription 3 epidermal growth factor Drp1 apoptosis mitochondria microglia neurodegeneration multiple sclerosis retinal microglia microglia morphotype light damage functional analysis early detection remodeling lactate GPR81 HCAR1 growth cone dLGN axon 3,5-DHBA kallikrein-kinin system kinin receptors GFAP osteopontin retinal detachment diabetes antioxidants bioenergetics respiration ATP glucagon-like peptide-1 exendin-4 catalase immunohistochemistry electron microscopy Charles Bonnet syndrome EEG visual hallucination resting state high-fat diet gut microbiome gut-retina axis RNA sequencing germ-free mice complement cascade angiogenesis retinal inflammation AII amacrine cell Prox1 parvalbumin gap junction eccentricity ON/OFF asymmetry arterioles betulinic acid ischemia-reperfusion injury reactive oxygen species retinal vessels retinal fluorescence imaging amyloid cognitive decline Alzheimer’s disease optic neuritis oxidative stress neuroprotection fingolimod iPSC-RPE retinal pigment epithelium immunodeficient RCS rat ultrathin parylene retinal transplantation CD4+CD25+ inflammation iPSC typical cannabinoid receptors atypical cannabinoid receptors electroretinography monkeys visual system eye inflammation lipopolysaccharide natural bioactive extracts Ac2-26 FPR receptor inflammatory mediators retinal light injury LED screen optical filter retinal protection regeneration progenitor cell hyperglycemia photoreceptors neurod Notch n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The Retina in Health and Disease |
| title | The Retina in Health and Disease |
| title_full | The Retina in Health and Disease |
| title_fullStr | The Retina in Health and Disease |
| title_full_unstemmed | The Retina in Health and Disease |
| title_short | The Retina in Health and Disease |
| title_sort | retina in health and disease |
| topic | eye retina development vascularization hypoxia autophagy programmed cell death cellular senescence retinogenesis altricial bird species precocial bird species senescence-associated galactosidase activity diabetes mellitus retinopathy microvascular complication optical coherence tomography angiography black African-American systemic disease biomarker retinal degenerative diseases mesenchymal stem cells stem cell therapy experimental models clinical trials AMD age-related macular degeneration trichostatin A (TSA) HDAC histone deacetylase vascular endothelial growth factor (VEGF) retinal degeneration endoplasmic reticulum stress response unfolded protein response GRP78 retinal glial cell diabetic retinopathy zebrafish neurovascular unit microvascular complications and dysfunction metabolism motor protein myosin 1C photoreceptor rhodopsin outer segments visual function macroglia astrocytes Müller cells optic nerve crush retinal ganglion cells spinal cord injury signal transducer and activator of transcription 3 epidermal growth factor Drp1 apoptosis mitochondria microglia neurodegeneration multiple sclerosis retinal microglia microglia morphotype light damage functional analysis early detection remodeling lactate GPR81 HCAR1 growth cone dLGN axon 3,5-DHBA kallikrein-kinin system kinin receptors GFAP osteopontin retinal detachment diabetes antioxidants bioenergetics respiration ATP glucagon-like peptide-1 exendin-4 catalase immunohistochemistry electron microscopy Charles Bonnet syndrome EEG visual hallucination resting state high-fat diet gut microbiome gut-retina axis RNA sequencing germ-free mice complement cascade angiogenesis retinal inflammation AII amacrine cell Prox1 parvalbumin gap junction eccentricity ON/OFF asymmetry arterioles betulinic acid ischemia-reperfusion injury reactive oxygen species retinal vessels retinal fluorescence imaging amyloid cognitive decline Alzheimer’s disease optic neuritis oxidative stress neuroprotection fingolimod iPSC-RPE retinal pigment epithelium immunodeficient RCS rat ultrathin parylene retinal transplantation CD4+CD25+ inflammation iPSC typical cannabinoid receptors atypical cannabinoid receptors electroretinography monkeys visual system eye inflammation lipopolysaccharide natural bioactive extracts Ac2-26 FPR receptor inflammatory mediators retinal light injury LED screen optical filter retinal protection regeneration progenitor cell hyperglycemia photoreceptors neurod Notch n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | eye retina development vascularization hypoxia autophagy programmed cell death cellular senescence retinogenesis altricial bird species precocial bird species senescence-associated galactosidase activity diabetes mellitus retinopathy microvascular complication optical coherence tomography angiography black African-American systemic disease biomarker retinal degenerative diseases mesenchymal stem cells stem cell therapy experimental models clinical trials AMD age-related macular degeneration trichostatin A (TSA) HDAC histone deacetylase vascular endothelial growth factor (VEGF) retinal degeneration endoplasmic reticulum stress response unfolded protein response GRP78 retinal glial cell diabetic retinopathy zebrafish neurovascular unit microvascular complications and dysfunction metabolism motor protein myosin 1C photoreceptor rhodopsin outer segments visual function macroglia astrocytes Müller cells optic nerve crush retinal ganglion cells spinal cord injury signal transducer and activator of transcription 3 epidermal growth factor Drp1 apoptosis mitochondria microglia neurodegeneration multiple sclerosis retinal microglia microglia morphotype light damage functional analysis early detection remodeling lactate GPR81 HCAR1 growth cone dLGN axon 3,5-DHBA kallikrein-kinin system kinin receptors GFAP osteopontin retinal detachment diabetes antioxidants bioenergetics respiration ATP glucagon-like peptide-1 exendin-4 catalase immunohistochemistry electron microscopy Charles Bonnet syndrome EEG visual hallucination resting state high-fat diet gut microbiome gut-retina axis RNA sequencing germ-free mice complement cascade angiogenesis retinal inflammation AII amacrine cell Prox1 parvalbumin gap junction eccentricity ON/OFF asymmetry arterioles betulinic acid ischemia-reperfusion injury reactive oxygen species retinal vessels retinal fluorescence imaging amyloid cognitive decline Alzheimer’s disease optic neuritis oxidative stress neuroprotection fingolimod iPSC-RPE retinal pigment epithelium immunodeficient RCS rat ultrathin parylene retinal transplantation CD4+CD25+ inflammation iPSC typical cannabinoid receptors atypical cannabinoid receptors electroretinography monkeys visual system eye inflammation lipopolysaccharide natural bioactive extracts Ac2-26 FPR receptor inflammatory mediators retinal light injury LED screen optical filter retinal protection regeneration progenitor cell hyperglycemia photoreceptors neurod Notch n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | ONIX_20220111_9783036526539_958 |