Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges
Glycosaminoglycans are linear, anionic polysaccharides (GAGs) consisting of repeating disaccharides. GAGs are ubiquitously localized throughout the extracellular matrix (ECM) and to the cell membranes of cells in all tissues. They are either conjugated to protein cores in the form of proteoglycans,...
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| Materiálatiipa: | Online |
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| Giella: | eaŋgalasgiella |
| Almmustuhtton: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Fáttát: | |
| Liŋkkat: | ONIX_20220111_9783036526775_975 |
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| _version_ | 1869525570848555008 |
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| collection | Directory of Open Access Books |
| description | Glycosaminoglycans are linear, anionic polysaccharides (GAGs) consisting of repeating disaccharides. GAGs are ubiquitously localized throughout the extracellular matrix (ECM) and to the cell membranes of cells in all tissues. They are either conjugated to protein cores in the form of proteoglycans, e.g., chondroitin/dermatan sulfate (CS/DS), heparin/heparan sulfate (Hep/HS) and keratan sulfate (KS), as well as non-sulfated hyaluronan (HA). By modulating biological signaling GAGs participate in the regulation of homeostasis and also participate in disease progression. The book, entitled “Exploring the multifaceted roles of glycosaminoglycans (GAGs)—new advances and further challenges”, features original research and review articles. These articles cover several GAG-related timely topics in structural biology and imaging; morphogenesis, cancer, and other disease therapy and drug developments; tissue engineering; and metabolic engineering. This book also includes an article illustrating how metabolic engineering can be used to create the novel chondroitin-like polysaccharide.A prerequisite for communicating in any discipline and across disciplines is familiarity with the appropriate terminology. Several nomenclature rules exist in the field of biochemistry. The historical description of GAGs follows IUPAC and IUB nomenclature. New structural depictions such as the structural nomenclature for glycan and their translation into machine-readable formats have opened the route for cross-references with popular bioinformatics resources and further connections with other exciting “omics” fields. |
| format | Online |
| id | doab-20.500.12854ir-77144 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-771442024-03-28T03:33:45Z Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges Nikitovic, Dragana Perez, Serge GAGs: Hyaluronic Acid, Heparan (Sulfate) Heparin, Heparosan Chondroitin Dermatan Keratan, GAGs like Peri and Extracellular Matrix Regulation & Biosynthesis of GAG Extraction Synthesis (chemical, metabolic engineering,...) Characterization sequence molecular weight, degree polymerization, 3D structures,....) structure/properties relationships oligosaccharides Glycobiology structure/function relationship Protein-GAG complexes in disease GAG-based biomaterials as nanocarriers thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Glycosaminoglycans are linear, anionic polysaccharides (GAGs) consisting of repeating disaccharides. GAGs are ubiquitously localized throughout the extracellular matrix (ECM) and to the cell membranes of cells in all tissues. They are either conjugated to protein cores in the form of proteoglycans, e.g., chondroitin/dermatan sulfate (CS/DS), heparin/heparan sulfate (Hep/HS) and keratan sulfate (KS), as well as non-sulfated hyaluronan (HA). By modulating biological signaling GAGs participate in the regulation of homeostasis and also participate in disease progression. The book, entitled “Exploring the multifaceted roles of glycosaminoglycans (GAGs)—new advances and further challenges”, features original research and review articles. These articles cover several GAG-related timely topics in structural biology and imaging; morphogenesis, cancer, and other disease therapy and drug developments; tissue engineering; and metabolic engineering. This book also includes an article illustrating how metabolic engineering can be used to create the novel chondroitin-like polysaccharide.A prerequisite for communicating in any discipline and across disciplines is familiarity with the appropriate terminology. Several nomenclature rules exist in the field of biochemistry. The historical description of GAGs follows IUPAC and IUB nomenclature. New structural depictions such as the structural nomenclature for glycan and their translation into machine-readable formats have opened the route for cross-references with popular bioinformatics resources and further connections with other exciting “omics” fields. 2022-01-11T13:53:43Z 2022-01-11T13:53:43Z 2021 book ONIX_20220111_9783036526775_975 9783036526775 9783036526768 https://directory.doabooks.org/handle/20.500.12854/77144 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4762 https://mdpi.com/books/pdfview/book/4762 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-2676-8 10.3390/books978-3-0365-2676-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036526775 9783036526768 313 Basel, Switzerland open access |
| spellingShingle | GAGs: Hyaluronic Acid, Heparan (Sulfate) Heparin, Heparosan Chondroitin Dermatan Keratan, GAGs like Peri and Extracellular Matrix Regulation & Biosynthesis of GAG Extraction Synthesis (chemical, metabolic engineering,...) Characterization sequence molecular weight, degree polymerization, 3D structures,....) structure/properties relationships oligosaccharides Glycobiology structure/function relationship Protein-GAG complexes in disease GAG-based biomaterials as nanocarriers thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges |
| title | Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges |
| title_full | Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges |
| title_fullStr | Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges |
| title_full_unstemmed | Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges |
| title_short | Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges |
| title_sort | exploring the multifaceted roles of glycosaminoglycans gags new advances and further challenges |
| topic | GAGs: Hyaluronic Acid, Heparan (Sulfate) Heparin, Heparosan Chondroitin Dermatan Keratan, GAGs like Peri and Extracellular Matrix Regulation & Biosynthesis of GAG Extraction Synthesis (chemical, metabolic engineering,...) Characterization sequence molecular weight, degree polymerization, 3D structures,....) structure/properties relationships oligosaccharides Glycobiology structure/function relationship Protein-GAG complexes in disease GAG-based biomaterials as nanocarriers thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | GAGs: Hyaluronic Acid, Heparan (Sulfate) Heparin, Heparosan Chondroitin Dermatan Keratan, GAGs like Peri and Extracellular Matrix Regulation & Biosynthesis of GAG Extraction Synthesis (chemical, metabolic engineering,...) Characterization sequence molecular weight, degree polymerization, 3D structures,....) structure/properties relationships oligosaccharides Glycobiology structure/function relationship Protein-GAG complexes in disease GAG-based biomaterials as nanocarriers thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | ONIX_20220111_9783036526775_975 |