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Targeted Cancer Therapy and Mechanisms of Resistance

Tumor cells commonly exhibit dependence on a single activated oncogenic pathway or protein to maintain their malignant proliferation and survival, a phenomenon called “oncogene addiction”. According to this concept, protein kinases have been identified as promising molecular targets for cancer thera...

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Format: Online
Language:English
Published: MDPI - Multidisciplinary Digital Publishing Institute 2022
Subjects:
3D spheroids
photothermy
gold nanoparticles
doxorubicin resistance
colorectal cancer
cellular prion protein
PrPC
PRNP
cancer
cancer stem cell
targeted cancer therapy
brain metastases
treatment
non-small cell lung carcinoma
EGFR
ALK
immunotherapy
HDAC6
bortezomib-resistance
HDAC6-selective inhibitor
bortezomib
carfilzomib
multiple myeloma
LMP2
combination therapy
colorectal cancer cells
drug resistance
5-Fluorouracil
thymidylate synthase
exome sequencing
CD47
immune activation
pro-tumoral macrophages
breast cancer
polo-like kinase 1 (PLK1)
pyrazole
quantitative structure-activity relationship
hybridization
ovarian cancer
cisplatin
cisplatin resistance
PARPi
niraparib
Twist
lethality
AF4
cell culture
FGFR2
HOXA9
MLL-AF4
nucleus
target therapy
t(4
11) leukemia
radiation-resistant
cell death
ERK
EMT
cancer stem cells (CSCs)
PD98059
PARP inhibitors
PARP inhibitor resistance
signal transduction networks
pathways
event-free survival
biomarkers
WNT pathway
targeted therapy
Wee1 kinase
cell cycle
tumor resistance
lenvatinib
sorafenib-resistant
hepatocellular carcinoma
FGFR4
autophagy
microRNA
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Online Access:ONIX_20220224_9783036528564_33
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