Novel Antibacterial Agents
This book was devoted to the latest advances achieved in the antibacterial field, with a focus on the recent efforts made to develop new antimicrobial agents with novel modes of action, and a perspective on future directions of this line of research. Antimicrobial resistance has become a major threa...
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| Formato: | Online |
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| Idioma: | inglés |
| Publicado: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Acceso en liña: | ONIX_20220224_9783036528601_37 |
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| _version_ | 1869530360241455104 |
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| collection | Directory of Open Access Books |
| description | This book was devoted to the latest advances achieved in the antibacterial field, with a focus on the recent efforts made to develop new antimicrobial agents with novel modes of action, and a perspective on future directions of this line of research. Antimicrobial resistance has become a major threat to global health, and the twenty-two published articles here reported put in evidence that the discovery and development of new antibiotics are extremely challenging. The antimicrobial research covers a wide area, spanning from the design of new compounds, also supported by molecular modeling techniques, their synthesis and characterization, and biological tests.In this context, the current crisis caused by the COVID-19 pandemic, but also older threats, such as the human immunodeficiency virus or the hepatitis C virus, require greater attention than ever.The research works described in this book provide an extremely useful example of the results achieved in the field of antibacterial drug development. The search for new chemical entities was approached starting from both natural and synthetic compounds and addressing different targets. In addition, recent findings were presented and discussed highlighting the strategies to fight bacterial resistance. Detailed references to the state-of-the-art can be found in this book.We strongly encourage the wide group of readers to explore the book that we are presenting, to get inspired to develop new approaches for the diagnosis and treatment of antibacterial diseases, and to circumvent resistance issues. |
| format | Online |
| id | doab-20.500.12854ir-78739 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-787392024-03-28T03:32:35Z Novel Antibacterial Agents Meneghetti, Fiorella Barlocco, Daniela saccharin tetrazole 1,3,4-thiadiazole H7PX glioma cells antimicrobial screening antioxidant capacity oxidative stress natural products medicinal plants anti-infective agents alternative infection models antibacterial anticancer GC-MS LIBS Moringa oleifera seed extract MRSA marine bisindole alkaloids antibiofilm activity adjuvants agents VBNC cells indole thioxothiazolidine antibacterial activity antifungal activity computer-aided prediction docking Mur B CYP 51 plant compounds diarrhea selectivity compounds screening quorum sensing inhibition molecular docking AMP antimicrobial activity antiviral activity bacteriocin COVID-19 disinfectant Lactobacillus plantarum plantaricin carbon nanotubes quaternary ammonium groups hyperbranched dendritic polymers antibacterial properties anti-cyanobacterial properties 3D-printing dental polymer antibacterial agent coating mesoporous silica nanoparticles polydimethylsiloxane Leishmania tropica and infantum antileishmanial agents lucanthone analogues amitriptyline analogues quinolizidine-derived compounds molecular modelling studies covalent inhibitor MurA cyclobutenaminone irreversible methicillin-resistant Staphylococcus aureus essential oils Origanum majorana Rosmarinus officinalis Thymus zygis biofilm inhibition and eradication urushiol 3-pentylcatechol 3-pentadecylcatechol Helicobacter pylori antimicrobial triple therapy atopic dermatitis skin barrier cutaneous dysbiosis Staphylococcus aureus microbial therapy drug delivery systems tris(1H-indol-3-yl)methylium turbomycin indole derivatives antibacterial action overcoming of drug resistance biological activities essential oil extract Thymus mastichina imidazole and imidazolium salts amino acid antibacterial agents aggregation lipophilicity antimicrobial peptide biomembranes ESKAPE antibiotic resistance NMR molecular dynamics biophysics sequence alignment lytic infection antibiotic-resistance Mycobacterium tuberculosis Acinetobacter baumannii Pseudomonas aeruginosa phage production magistral phage pulmonary delivery oral administration topical delivery Pinus cembra L. Pinus mugo Turra Picea abies L. Abies alba M. chemical investigation HS-GC/MS antioxidant activity tuberculosis mycobactins furan siderophores drug design bioisosterism drug resistance n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general This book was devoted to the latest advances achieved in the antibacterial field, with a focus on the recent efforts made to develop new antimicrobial agents with novel modes of action, and a perspective on future directions of this line of research. Antimicrobial resistance has become a major threat to global health, and the twenty-two published articles here reported put in evidence that the discovery and development of new antibiotics are extremely challenging. The antimicrobial research covers a wide area, spanning from the design of new compounds, also supported by molecular modeling techniques, their synthesis and characterization, and biological tests.In this context, the current crisis caused by the COVID-19 pandemic, but also older threats, such as the human immunodeficiency virus or the hepatitis C virus, require greater attention than ever.The research works described in this book provide an extremely useful example of the results achieved in the field of antibacterial drug development. The search for new chemical entities was approached starting from both natural and synthetic compounds and addressing different targets. In addition, recent findings were presented and discussed highlighting the strategies to fight bacterial resistance. Detailed references to the state-of-the-art can be found in this book.We strongly encourage the wide group of readers to explore the book that we are presenting, to get inspired to develop new approaches for the diagnosis and treatment of antibacterial diseases, and to circumvent resistance issues. 2022-02-24T10:34:50Z 2022-02-24T10:34:50Z 2022 book ONIX_20220224_9783036528601_37 9783036528601 9783036528618 https://directory.doabooks.org/handle/20.500.12854/78739 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4830 https://mdpi.com/books/pdfview/book/4830 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-2860-1 10.3390/books978-3-0365-2860-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036528601 9783036528618 409 Basel open access |
| spellingShingle | saccharin tetrazole 1,3,4-thiadiazole H7PX glioma cells antimicrobial screening antioxidant capacity oxidative stress natural products medicinal plants anti-infective agents alternative infection models antibacterial anticancer GC-MS LIBS Moringa oleifera seed extract MRSA marine bisindole alkaloids antibiofilm activity adjuvants agents VBNC cells indole thioxothiazolidine antibacterial activity antifungal activity computer-aided prediction docking Mur B CYP 51 plant compounds diarrhea selectivity compounds screening quorum sensing inhibition molecular docking AMP antimicrobial activity antiviral activity bacteriocin COVID-19 disinfectant Lactobacillus plantarum plantaricin carbon nanotubes quaternary ammonium groups hyperbranched dendritic polymers antibacterial properties anti-cyanobacterial properties 3D-printing dental polymer antibacterial agent coating mesoporous silica nanoparticles polydimethylsiloxane Leishmania tropica and infantum antileishmanial agents lucanthone analogues amitriptyline analogues quinolizidine-derived compounds molecular modelling studies covalent inhibitor MurA cyclobutenaminone irreversible methicillin-resistant Staphylococcus aureus essential oils Origanum majorana Rosmarinus officinalis Thymus zygis biofilm inhibition and eradication urushiol 3-pentylcatechol 3-pentadecylcatechol Helicobacter pylori antimicrobial triple therapy atopic dermatitis skin barrier cutaneous dysbiosis Staphylococcus aureus microbial therapy drug delivery systems tris(1H-indol-3-yl)methylium turbomycin indole derivatives antibacterial action overcoming of drug resistance biological activities essential oil extract Thymus mastichina imidazole and imidazolium salts amino acid antibacterial agents aggregation lipophilicity antimicrobial peptide biomembranes ESKAPE antibiotic resistance NMR molecular dynamics biophysics sequence alignment lytic infection antibiotic-resistance Mycobacterium tuberculosis Acinetobacter baumannii Pseudomonas aeruginosa phage production magistral phage pulmonary delivery oral administration topical delivery Pinus cembra L. Pinus mugo Turra Picea abies L. Abies alba M. chemical investigation HS-GC/MS antioxidant activity tuberculosis mycobactins furan siderophores drug design bioisosterism drug resistance n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general Novel Antibacterial Agents |
| title | Novel Antibacterial Agents |
| title_full | Novel Antibacterial Agents |
| title_fullStr | Novel Antibacterial Agents |
| title_full_unstemmed | Novel Antibacterial Agents |
| title_short | Novel Antibacterial Agents |
| title_sort | novel antibacterial agents |
| topic | saccharin tetrazole 1,3,4-thiadiazole H7PX glioma cells antimicrobial screening antioxidant capacity oxidative stress natural products medicinal plants anti-infective agents alternative infection models antibacterial anticancer GC-MS LIBS Moringa oleifera seed extract MRSA marine bisindole alkaloids antibiofilm activity adjuvants agents VBNC cells indole thioxothiazolidine antibacterial activity antifungal activity computer-aided prediction docking Mur B CYP 51 plant compounds diarrhea selectivity compounds screening quorum sensing inhibition molecular docking AMP antimicrobial activity antiviral activity bacteriocin COVID-19 disinfectant Lactobacillus plantarum plantaricin carbon nanotubes quaternary ammonium groups hyperbranched dendritic polymers antibacterial properties anti-cyanobacterial properties 3D-printing dental polymer antibacterial agent coating mesoporous silica nanoparticles polydimethylsiloxane Leishmania tropica and infantum antileishmanial agents lucanthone analogues amitriptyline analogues quinolizidine-derived compounds molecular modelling studies covalent inhibitor MurA cyclobutenaminone irreversible methicillin-resistant Staphylococcus aureus essential oils Origanum majorana Rosmarinus officinalis Thymus zygis biofilm inhibition and eradication urushiol 3-pentylcatechol 3-pentadecylcatechol Helicobacter pylori antimicrobial triple therapy atopic dermatitis skin barrier cutaneous dysbiosis Staphylococcus aureus microbial therapy drug delivery systems tris(1H-indol-3-yl)methylium turbomycin indole derivatives antibacterial action overcoming of drug resistance biological activities essential oil extract Thymus mastichina imidazole and imidazolium salts amino acid antibacterial agents aggregation lipophilicity antimicrobial peptide biomembranes ESKAPE antibiotic resistance NMR molecular dynamics biophysics sequence alignment lytic infection antibiotic-resistance Mycobacterium tuberculosis Acinetobacter baumannii Pseudomonas aeruginosa phage production magistral phage pulmonary delivery oral administration topical delivery Pinus cembra L. Pinus mugo Turra Picea abies L. Abies alba M. chemical investigation HS-GC/MS antioxidant activity tuberculosis mycobactins furan siderophores drug design bioisosterism drug resistance n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general |
| topic_facet | saccharin tetrazole 1,3,4-thiadiazole H7PX glioma cells antimicrobial screening antioxidant capacity oxidative stress natural products medicinal plants anti-infective agents alternative infection models antibacterial anticancer GC-MS LIBS Moringa oleifera seed extract MRSA marine bisindole alkaloids antibiofilm activity adjuvants agents VBNC cells indole thioxothiazolidine antibacterial activity antifungal activity computer-aided prediction docking Mur B CYP 51 plant compounds diarrhea selectivity compounds screening quorum sensing inhibition molecular docking AMP antimicrobial activity antiviral activity bacteriocin COVID-19 disinfectant Lactobacillus plantarum plantaricin carbon nanotubes quaternary ammonium groups hyperbranched dendritic polymers antibacterial properties anti-cyanobacterial properties 3D-printing dental polymer antibacterial agent coating mesoporous silica nanoparticles polydimethylsiloxane Leishmania tropica and infantum antileishmanial agents lucanthone analogues amitriptyline analogues quinolizidine-derived compounds molecular modelling studies covalent inhibitor MurA cyclobutenaminone irreversible methicillin-resistant Staphylococcus aureus essential oils Origanum majorana Rosmarinus officinalis Thymus zygis biofilm inhibition and eradication urushiol 3-pentylcatechol 3-pentadecylcatechol Helicobacter pylori antimicrobial triple therapy atopic dermatitis skin barrier cutaneous dysbiosis Staphylococcus aureus microbial therapy drug delivery systems tris(1H-indol-3-yl)methylium turbomycin indole derivatives antibacterial action overcoming of drug resistance biological activities essential oil extract Thymus mastichina imidazole and imidazolium salts amino acid antibacterial agents aggregation lipophilicity antimicrobial peptide biomembranes ESKAPE antibiotic resistance NMR molecular dynamics biophysics sequence alignment lytic infection antibiotic-resistance Mycobacterium tuberculosis Acinetobacter baumannii Pseudomonas aeruginosa phage production magistral phage pulmonary delivery oral administration topical delivery Pinus cembra L. Pinus mugo Turra Picea abies L. Abies alba M. chemical investigation HS-GC/MS antioxidant activity tuberculosis mycobactins furan siderophores drug design bioisosterism drug resistance n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general |
| url | ONIX_20220224_9783036528601_37 |