A Changing Perspective for Treatment of Chronic Kidney Disease
Chronic kidney disease (CKD) has become an enormous worldwide health problem, both in developed and less developed countries. The incidence and prevalence of CKD is high, and is associated with increased mortality and morbidity. Of note, CKD is the 12th most common primary cause of death, accountin...
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| Formaat: | Online |
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| Taal: | Engels |
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MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Online toegang: | ONIX_20220224_9783036527956_38 |
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| description | Chronic kidney disease (CKD) has become an enormous worldwide health problem, both in developed and less developed countries. The incidence and prevalence of CKD is high, and is associated with increased mortality and morbidity. Of note, CKD is the 12th most common primary cause of death, accounting for about 1 million deaths per year worldwide. CKD and end-stage renal disease are characterized by the progressive development of a series of complications, such as anemia, hyperkalemia, hypervolemia, mineral and bone disorders (CKD-MBD), metabolic acidosis, hyperuricemia and wasting; all of these complications have been shown to be associated with adverse outcomes, and can contribute either individually or in association to the cardiovascular morbidity and mortality observed in CKD. While at this time CKD progression is not treated with high efficacy, new biomarkers of kidney fibrosis have become available in recent years and new treatments for kidney fibrosis and cell loss could become soon available. In addition recent progress in our understanding of CKD pathophysiology together with the development of novel therapeutic agents has led to a renewed attention on the treatment of CKD–associated metabolic complications which are now are amenable to therapeutic interventions. All these important issues are addressed in this volume. |
| format | Online |
| id | doab-20.500.12854ir-78740 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-787402024-04-11T15:10:25Z A Changing Perspective for Treatment of Chronic Kidney Disease Garibotto, Giacomo heatmap clustering multivariate statistical analysis chronic kidney disease risk factors acute kidney injury radical nephrectomy functional change ratio diabetic kidney disease GLP-1 calciprotein particles calcification propensity vascular calcification hyperkalemia heart failure sodium polystyrene sulfonate patiromer sodium zirconium cyclosilicate alcohol cadmium diet lifestyle related exposures lead proteinuria smoking type 2 diabetes left ventricular hypertrophy left ventricular mass index hemodialysis blood pressure cardiovascular events risk factor hyperphosphatemia cardiovascular disease endothelial cells procoagulant MVs multidimensional prognostic index peritoneal dialysis hospitalization mortality hyperuricemia urate lowering treatment MANBA variants estimated glomerular filtration rate (eGFR) expression quantitative trait loci (eQTL) CKD–MBD thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology Chronic kidney disease (CKD) has become an enormous worldwide health problem, both in developed and less developed countries. The incidence and prevalence of CKD is high, and is associated with increased mortality and morbidity. Of note, CKD is the 12th most common primary cause of death, accounting for about 1 million deaths per year worldwide. CKD and end-stage renal disease are characterized by the progressive development of a series of complications, such as anemia, hyperkalemia, hypervolemia, mineral and bone disorders (CKD-MBD), metabolic acidosis, hyperuricemia and wasting; all of these complications have been shown to be associated with adverse outcomes, and can contribute either individually or in association to the cardiovascular morbidity and mortality observed in CKD. While at this time CKD progression is not treated with high efficacy, new biomarkers of kidney fibrosis have become available in recent years and new treatments for kidney fibrosis and cell loss could become soon available. In addition recent progress in our understanding of CKD pathophysiology together with the development of novel therapeutic agents has led to a renewed attention on the treatment of CKD–associated metabolic complications which are now are amenable to therapeutic interventions. All these important issues are addressed in this volume. 2022-02-24T10:34:53Z 2022-02-24T10:34:53Z 2022 book ONIX_20220224_9783036527956_38 9783036527956 9783036527949 https://directory.doabooks.org/handle/20.500.12854/78740 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4831 https://mdpi.com/books/pdfview/book/4831 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-2795-6 10.3390/books978-3-0365-2795-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036527956 9783036527949 158 Basel open access |
| spellingShingle | heatmap clustering multivariate statistical analysis chronic kidney disease risk factors acute kidney injury radical nephrectomy functional change ratio diabetic kidney disease GLP-1 calciprotein particles calcification propensity vascular calcification hyperkalemia heart failure sodium polystyrene sulfonate patiromer sodium zirconium cyclosilicate alcohol cadmium diet lifestyle related exposures lead proteinuria smoking type 2 diabetes left ventricular hypertrophy left ventricular mass index hemodialysis blood pressure cardiovascular events risk factor hyperphosphatemia cardiovascular disease endothelial cells procoagulant MVs multidimensional prognostic index peritoneal dialysis hospitalization mortality hyperuricemia urate lowering treatment MANBA variants estimated glomerular filtration rate (eGFR) expression quantitative trait loci (eQTL) CKD–MBD thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology A Changing Perspective for Treatment of Chronic Kidney Disease |
| title | A Changing Perspective for Treatment of Chronic Kidney Disease |
| title_full | A Changing Perspective for Treatment of Chronic Kidney Disease |
| title_fullStr | A Changing Perspective for Treatment of Chronic Kidney Disease |
| title_full_unstemmed | A Changing Perspective for Treatment of Chronic Kidney Disease |
| title_short | A Changing Perspective for Treatment of Chronic Kidney Disease |
| title_sort | changing perspective for treatment of chronic kidney disease |
| topic | heatmap clustering multivariate statistical analysis chronic kidney disease risk factors acute kidney injury radical nephrectomy functional change ratio diabetic kidney disease GLP-1 calciprotein particles calcification propensity vascular calcification hyperkalemia heart failure sodium polystyrene sulfonate patiromer sodium zirconium cyclosilicate alcohol cadmium diet lifestyle related exposures lead proteinuria smoking type 2 diabetes left ventricular hypertrophy left ventricular mass index hemodialysis blood pressure cardiovascular events risk factor hyperphosphatemia cardiovascular disease endothelial cells procoagulant MVs multidimensional prognostic index peritoneal dialysis hospitalization mortality hyperuricemia urate lowering treatment MANBA variants estimated glomerular filtration rate (eGFR) expression quantitative trait loci (eQTL) CKD–MBD thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology |
| topic_facet | heatmap clustering multivariate statistical analysis chronic kidney disease risk factors acute kidney injury radical nephrectomy functional change ratio diabetic kidney disease GLP-1 calciprotein particles calcification propensity vascular calcification hyperkalemia heart failure sodium polystyrene sulfonate patiromer sodium zirconium cyclosilicate alcohol cadmium diet lifestyle related exposures lead proteinuria smoking type 2 diabetes left ventricular hypertrophy left ventricular mass index hemodialysis blood pressure cardiovascular events risk factor hyperphosphatemia cardiovascular disease endothelial cells procoagulant MVs multidimensional prognostic index peritoneal dialysis hospitalization mortality hyperuricemia urate lowering treatment MANBA variants estimated glomerular filtration rate (eGFR) expression quantitative trait loci (eQTL) CKD–MBD thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology |
| url | ONIX_20220224_9783036527956_38 |