Arteriogenesis and Therapeutic Angiogenesis
Although advances in therapeutic interventions improved outcomes, vascular occlusive diseases are still challenging not only afflicted but also attending physicians, requiring novel therapeutic strategies. Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body’s own capac...
Tallennettuna:
| Aineistotyyppi: | Online |
|---|---|
| Kieli: | englanti |
| Julkaistu: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
|
| Aiheet: | |
| Linkit: | ONIX_20220224_9783036527178_39 |
| Tagit: |
Ei tageja, Lisää ensimmäinen tagi!
|
| _version_ | 1869517550249836544 |
|---|---|
| collection | Directory of Open Access Books |
| description | Although advances in therapeutic interventions improved outcomes, vascular occlusive diseases are still challenging not only afflicted but also attending physicians, requiring novel therapeutic strategies. Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body’s own capacity to create a natural bypass around a narrowing or occluded arterial vessel. This book gives an insight into current knowledge and advances in vascular sciences and future prospects of therapeutic options. The utility and relevance of circulating biomarkers together with the potential of machine learning methods are discussed as well as the challenges and prospects of novel therapies such as protein- gene-, and stem cell therapy along with multicistronic multigene vectors and the use of microRNAs, exosomes, and secretomes. Vascular smooth muscle phenotype switch as a target to promote arteriogenesis is critically addressed, highlighting the problem of promoting atherosclerosis in parallel. Two articles even deal with cold-inducible RNA-binding protein CIRP/CIRPB presenting it as promising target to promote vascularization concomitant the reduction in ischemic tissue damage. BMPR kinase inhibition is introduced to improve tissue repair in a hereditary form of vascular disorder, and the role of the AP-1 transcription factor JunB in blood vessel formation is described. Some more experimental oriented articles deal with the relevance of choosing the appropriate mouse strain for investigations as well as in vitro Matrigel plug assay as a potent method to investigate angiogenesis. Last but not least, two-photon intravital microscopy is presented as suitable tool to assess plaque angiogenesis in atherosclerotic lesions. |
| format | Online |
| id | doab-20.500.12854ir-78741 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-787412024-03-30T23:22:08Z Arteriogenesis and Therapeutic Angiogenesis Quax, Paul Deindl, Elisabeth angiogenesis vessel maturity vessel permeability hemorrhage atherosclerosis two-photon intravital microscopy transforming growth factor-β endoglin neovascularization tissue repair myocardial infarction hind limb ischemia critical limb ischemia arteriogenesis cell therapy secretomes AP-1 transcription factors JunB tip cell specification vascular development neurovascular interactions peripheral arterial disease biomarkers inflammation coagulation extracellular vesicles microRNAs machine learning gene therapy stem cells clinical trials bioengineering gene expression non-viral vectors 2A-peptides growth factors tube formation VEGF FGF2 cytokines animal model Matrigel plug assay cold-inducible RNA-binding protein extracellular cold-inducible RNA-binding protein CIRP eCIRP neutrophil extracellular traps NETs macrophage polarization apoptosis ischemia vascular smooth muscle cell phenotypic switch collateral arteries C57BL/6J mice SV-129 mice leukocytes macrophages neutrophils C57BL6 129S1/Sv CIRBP 14q32 microRNAs HUVECs n/a thema EDItEUR::M Medicine and Nursing Although advances in therapeutic interventions improved outcomes, vascular occlusive diseases are still challenging not only afflicted but also attending physicians, requiring novel therapeutic strategies. Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body’s own capacity to create a natural bypass around a narrowing or occluded arterial vessel. This book gives an insight into current knowledge and advances in vascular sciences and future prospects of therapeutic options. The utility and relevance of circulating biomarkers together with the potential of machine learning methods are discussed as well as the challenges and prospects of novel therapies such as protein- gene-, and stem cell therapy along with multicistronic multigene vectors and the use of microRNAs, exosomes, and secretomes. Vascular smooth muscle phenotype switch as a target to promote arteriogenesis is critically addressed, highlighting the problem of promoting atherosclerosis in parallel. Two articles even deal with cold-inducible RNA-binding protein CIRP/CIRPB presenting it as promising target to promote vascularization concomitant the reduction in ischemic tissue damage. BMPR kinase inhibition is introduced to improve tissue repair in a hereditary form of vascular disorder, and the role of the AP-1 transcription factor JunB in blood vessel formation is described. Some more experimental oriented articles deal with the relevance of choosing the appropriate mouse strain for investigations as well as in vitro Matrigel plug assay as a potent method to investigate angiogenesis. Last but not least, two-photon intravital microscopy is presented as suitable tool to assess plaque angiogenesis in atherosclerotic lesions. 2022-02-24T10:34:55Z 2022-02-24T10:34:55Z 2022 book ONIX_20220224_9783036527178_39 9783036527178 9783036527161 https://directory.doabooks.org/handle/20.500.12854/78741 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4832 https://mdpi.com/books/pdfview/book/4832 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-2717-8 10.3390/books978-3-0365-2717-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036527178 9783036527161 230 Basel open access |
| spellingShingle | angiogenesis vessel maturity vessel permeability hemorrhage atherosclerosis two-photon intravital microscopy transforming growth factor-β endoglin neovascularization tissue repair myocardial infarction hind limb ischemia critical limb ischemia arteriogenesis cell therapy secretomes AP-1 transcription factors JunB tip cell specification vascular development neurovascular interactions peripheral arterial disease biomarkers inflammation coagulation extracellular vesicles microRNAs machine learning gene therapy stem cells clinical trials bioengineering gene expression non-viral vectors 2A-peptides growth factors tube formation VEGF FGF2 cytokines animal model Matrigel plug assay cold-inducible RNA-binding protein extracellular cold-inducible RNA-binding protein CIRP eCIRP neutrophil extracellular traps NETs macrophage polarization apoptosis ischemia vascular smooth muscle cell phenotypic switch collateral arteries C57BL/6J mice SV-129 mice leukocytes macrophages neutrophils C57BL6 129S1/Sv CIRBP 14q32 microRNAs HUVECs n/a thema EDItEUR::M Medicine and Nursing Arteriogenesis and Therapeutic Angiogenesis |
| title | Arteriogenesis and Therapeutic Angiogenesis |
| title_full | Arteriogenesis and Therapeutic Angiogenesis |
| title_fullStr | Arteriogenesis and Therapeutic Angiogenesis |
| title_full_unstemmed | Arteriogenesis and Therapeutic Angiogenesis |
| title_short | Arteriogenesis and Therapeutic Angiogenesis |
| title_sort | arteriogenesis and therapeutic angiogenesis |
| topic | angiogenesis vessel maturity vessel permeability hemorrhage atherosclerosis two-photon intravital microscopy transforming growth factor-β endoglin neovascularization tissue repair myocardial infarction hind limb ischemia critical limb ischemia arteriogenesis cell therapy secretomes AP-1 transcription factors JunB tip cell specification vascular development neurovascular interactions peripheral arterial disease biomarkers inflammation coagulation extracellular vesicles microRNAs machine learning gene therapy stem cells clinical trials bioengineering gene expression non-viral vectors 2A-peptides growth factors tube formation VEGF FGF2 cytokines animal model Matrigel plug assay cold-inducible RNA-binding protein extracellular cold-inducible RNA-binding protein CIRP eCIRP neutrophil extracellular traps NETs macrophage polarization apoptosis ischemia vascular smooth muscle cell phenotypic switch collateral arteries C57BL/6J mice SV-129 mice leukocytes macrophages neutrophils C57BL6 129S1/Sv CIRBP 14q32 microRNAs HUVECs n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | angiogenesis vessel maturity vessel permeability hemorrhage atherosclerosis two-photon intravital microscopy transforming growth factor-β endoglin neovascularization tissue repair myocardial infarction hind limb ischemia critical limb ischemia arteriogenesis cell therapy secretomes AP-1 transcription factors JunB tip cell specification vascular development neurovascular interactions peripheral arterial disease biomarkers inflammation coagulation extracellular vesicles microRNAs machine learning gene therapy stem cells clinical trials bioengineering gene expression non-viral vectors 2A-peptides growth factors tube formation VEGF FGF2 cytokines animal model Matrigel plug assay cold-inducible RNA-binding protein extracellular cold-inducible RNA-binding protein CIRP eCIRP neutrophil extracellular traps NETs macrophage polarization apoptosis ischemia vascular smooth muscle cell phenotypic switch collateral arteries C57BL/6J mice SV-129 mice leukocytes macrophages neutrophils C57BL6 129S1/Sv CIRBP 14q32 microRNAs HUVECs n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20220224_9783036527178_39 |