Colorectal Cancer
Colorectal cancer is one of the most common malignancies worldwide, and the pathogenesis of this neoplasm is probably one of the most studied. The knowledge obtained over time has led to the development of screening and early diagnosis systems, allowing a significant reduction in the incidence of th...
-д хадгалсан:
| Формат: | Online |
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| Хэл сонгох: | англи |
| Хэвлэсэн: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Нөхцлүүд: | |
| Онлайн хандалт: | ONIX_20220224_9783036529233_47 |
| Шошгууд: |
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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| _version_ | 1869527866111164416 |
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| collection | Directory of Open Access Books |
| description | Colorectal cancer is one of the most common malignancies worldwide, and the pathogenesis of this neoplasm is probably one of the most studied. The knowledge obtained over time has led to the development of screening and early diagnosis systems, allowing a significant reduction in the incidence of this neoplasm. However, what is currently known probably represents only the tip of the iceberg of the biology of this tumor. It was recently shown that the gut microbiota may contribute to colorectal cancerogenesis. In addition, several novel targeted therapies are now applied to patients with colorectal carcinoma. Nonetheless, several questions are still unanswered. Could the modulation of the gut microbiota modify the risk of tumor progression or the efficacy of therapies? Are there any predictive biomarkers of the risk of tumor progression or the efficacy of target therapies? Is metastatic colorectal cancer one or more diseases? This book collects a series of scientific articles reflecting part of the state of the art regarding colorectal cancer, seeking to answer these questions. |
| format | Online |
| id | doab-20.500.12854ir-78749 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-787492024-03-31T13:09:55Z Colorectal Cancer Barresi, Valeria MSH2 3’UTR variant hereditary colon cancer Lynch syndrome MSH2 protein over expression MSH2 MMR gene MMR complex deficiency MSH2 unclassified variants liquid biopsy colorectal cancer biomarkers circulating tumor cells circulating tumor DNA genomic alterations metastasis tumor heterogeneity tumor evolution ADAM17 colorectal cancer (CRC) TNFα IL-6R AREG shedding regularized optimization Cox regression survival analysis TCGA data RNA-seq data gut microbiota colorectal adenoma polyps bacteria monoclonal antibody therapeutic target therapy colon cancer poorly differentiated clusters prognostic factors inflammatory markers histopathological markers immune system colorectal surgery nanofibrous materials anastomotic leakage intestinal anastomosis anastomotic patch polycaprolactone electrospinning experiment peritoneal adhesions CRC CTC ctDNA mi-RNA nc-RNA differentially expressed genes cancer stem cells qPCR chemoresistance TRIM8 miR-17-5p PDX patient-derived xenograft omega-3 fatty acids n/a thema EDItEUR::M Medicine and Nursing Colorectal cancer is one of the most common malignancies worldwide, and the pathogenesis of this neoplasm is probably one of the most studied. The knowledge obtained over time has led to the development of screening and early diagnosis systems, allowing a significant reduction in the incidence of this neoplasm. However, what is currently known probably represents only the tip of the iceberg of the biology of this tumor. It was recently shown that the gut microbiota may contribute to colorectal cancerogenesis. In addition, several novel targeted therapies are now applied to patients with colorectal carcinoma. Nonetheless, several questions are still unanswered. Could the modulation of the gut microbiota modify the risk of tumor progression or the efficacy of therapies? Are there any predictive biomarkers of the risk of tumor progression or the efficacy of target therapies? Is metastatic colorectal cancer one or more diseases? This book collects a series of scientific articles reflecting part of the state of the art regarding colorectal cancer, seeking to answer these questions. 2022-02-24T10:35:13Z 2022-02-24T10:35:13Z 2022 book ONIX_20220224_9783036529233_47 9783036529233 9783036529226 https://directory.doabooks.org/handle/20.500.12854/78749 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4841 https://mdpi.com/books/pdfview/book/4841 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-2923-3 10.3390/books978-3-0365-2923-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036529233 9783036529226 284 Basel open access |
| spellingShingle | MSH2 3’UTR variant hereditary colon cancer Lynch syndrome MSH2 protein over expression MSH2 MMR gene MMR complex deficiency MSH2 unclassified variants liquid biopsy colorectal cancer biomarkers circulating tumor cells circulating tumor DNA genomic alterations metastasis tumor heterogeneity tumor evolution ADAM17 colorectal cancer (CRC) TNFα IL-6R AREG shedding regularized optimization Cox regression survival analysis TCGA data RNA-seq data gut microbiota colorectal adenoma polyps bacteria monoclonal antibody therapeutic target therapy colon cancer poorly differentiated clusters prognostic factors inflammatory markers histopathological markers immune system colorectal surgery nanofibrous materials anastomotic leakage intestinal anastomosis anastomotic patch polycaprolactone electrospinning experiment peritoneal adhesions CRC CTC ctDNA mi-RNA nc-RNA differentially expressed genes cancer stem cells qPCR chemoresistance TRIM8 miR-17-5p PDX patient-derived xenograft omega-3 fatty acids n/a thema EDItEUR::M Medicine and Nursing Colorectal Cancer |
| title | Colorectal Cancer |
| title_full | Colorectal Cancer |
| title_fullStr | Colorectal Cancer |
| title_full_unstemmed | Colorectal Cancer |
| title_short | Colorectal Cancer |
| title_sort | colorectal cancer |
| topic | MSH2 3’UTR variant hereditary colon cancer Lynch syndrome MSH2 protein over expression MSH2 MMR gene MMR complex deficiency MSH2 unclassified variants liquid biopsy colorectal cancer biomarkers circulating tumor cells circulating tumor DNA genomic alterations metastasis tumor heterogeneity tumor evolution ADAM17 colorectal cancer (CRC) TNFα IL-6R AREG shedding regularized optimization Cox regression survival analysis TCGA data RNA-seq data gut microbiota colorectal adenoma polyps bacteria monoclonal antibody therapeutic target therapy colon cancer poorly differentiated clusters prognostic factors inflammatory markers histopathological markers immune system colorectal surgery nanofibrous materials anastomotic leakage intestinal anastomosis anastomotic patch polycaprolactone electrospinning experiment peritoneal adhesions CRC CTC ctDNA mi-RNA nc-RNA differentially expressed genes cancer stem cells qPCR chemoresistance TRIM8 miR-17-5p PDX patient-derived xenograft omega-3 fatty acids n/a thema EDItEUR::M Medicine and Nursing |
| topic_facet | MSH2 3’UTR variant hereditary colon cancer Lynch syndrome MSH2 protein over expression MSH2 MMR gene MMR complex deficiency MSH2 unclassified variants liquid biopsy colorectal cancer biomarkers circulating tumor cells circulating tumor DNA genomic alterations metastasis tumor heterogeneity tumor evolution ADAM17 colorectal cancer (CRC) TNFα IL-6R AREG shedding regularized optimization Cox regression survival analysis TCGA data RNA-seq data gut microbiota colorectal adenoma polyps bacteria monoclonal antibody therapeutic target therapy colon cancer poorly differentiated clusters prognostic factors inflammatory markers histopathological markers immune system colorectal surgery nanofibrous materials anastomotic leakage intestinal anastomosis anastomotic patch polycaprolactone electrospinning experiment peritoneal adhesions CRC CTC ctDNA mi-RNA nc-RNA differentially expressed genes cancer stem cells qPCR chemoresistance TRIM8 miR-17-5p PDX patient-derived xenograft omega-3 fatty acids n/a thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20220224_9783036529233_47 |