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O-GlcNAcylation and Cancer

This book gathers reviews and articles on the role of O-GlcNAcylation in cancer underlying the pharmacological targeting of the O-GlcNAcylation enzymes OGT and OGA as a promising anticancer strategy. Particular attention is paid to the involvement of O-GlcNAcylation in the regulation of transcriptio...

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Salvato in:
Natura: Online
Lingua:inglese
Pubblicazione: MDPI - Multidisciplinary Digital Publishing Institute 2022
Soggetti:
UNC5A
O-GlcNAcylation
OGT
EZH2
nutrition
epigenetics
colon cancer
transcription
O-GlcNAc
O-GlcNAc transferase
O-GlcNAcase
mOGT
mitochondria
glucose
energy metabolism
breast cancer
cellular stress
cancer
immune surveillance
invasiveness
lung adenocarcinoma
SAM68
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
Accesso online:ONIX_20220224_9783036530826_120
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Riassunto:This book gathers reviews and articles on the role of O-GlcNAcylation in cancer underlying the pharmacological targeting of the O-GlcNAcylation enzymes OGT and OGA as a promising anticancer strategy. Particular attention is paid to the involvement of O-GlcNAcylation in the regulation of transcription and as a link between nutrition and epigenetic dynamics or cellular energy metabolism. The role of O-GlcNAcylation in metastasis, immune responses, and resistance to chemotherapeutic agents is also discussed.

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