MicroRNA in Solid Tumor and Hematological Diseases
MicroRNAs (miRNAs), which are a type of short non-coding RNA, are involved in number of processes, such as differentiation, development, inflammation, immune response, and cancer. miRNAs, which act as oncogenes or tumor suppressor genes, can control and regulate the translation and stability of targ...
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| Formato: | Online |
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| Idioma: | inglês |
| Publicado em: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Acesso em linha: | ONIX_20220224_9783036530895_139 |
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| collection | Directory of Open Access Books |
| description | MicroRNAs (miRNAs), which are a type of short non-coding RNA, are involved in number of processes, such as differentiation, development, inflammation, immune response, and cancer. miRNAs, which act as oncogenes or tumor suppressor genes, can control and regulate the translation and stability of target messenger RNA, contributing to cancer pathogenesis. Despite the progress that has been made in discovering the mechanisms of how miRNAs function in tumors, many questions and aspects of miRNA biology and processing still remain to be determined. This Special Issue, titled “MicroRNA in Solid Tumor and Hematological Diseases”, provides a panorama of the existing knowledge gaps and potential uses of microRNAs to predict clinical outcome or response to therapies and provides evidence to explain their role as biomarkers to modulate the biological pathways that are critical for cancer development and progression. It includes eleven peer-reviewed papers that cover the role of microRNAs in different tumor types and their potential applications in diagnosis and clinical approaches. |
| format | Online |
| id | doab-20.500.12854ir-78842 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-788422024-03-28T03:33:03Z MicroRNA in Solid Tumor and Hematological Diseases Lovat, Francesca bladder cancer urine miRNA reference miRNA normalizer RT-qPCR miR-139-5p miR-139-3p renal cell carcinoma (RCC) microRNA tumor suppressor paxillin (PXN) acute myeloblastic leukemia acute lymphoblastic leukemia colorectal cancer amino acid transporters LAT1 ASCT2 miRNAs microRNAs GI cancers targeted therapy drug resistance miR-7 gene expression cancer cell prognosis follicular lymphoma marginal zone lymphoma Waldenström’s macroglobulinemia hairy cell leukemia primary cutaneous follicle center lymphoma normal B-cell development therapeutic target diagnosis solid cancer post-transcriptional regulation hepatocellular carcinoma Hippo kinase Yes-associated protein liver disease cancer therapy PDAC survival expression profiling ovarian cancer epithelial ovarian cancer liquid biopsy circulating miRNAs drug response personalized medicine chemotherapy n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general MicroRNAs (miRNAs), which are a type of short non-coding RNA, are involved in number of processes, such as differentiation, development, inflammation, immune response, and cancer. miRNAs, which act as oncogenes or tumor suppressor genes, can control and regulate the translation and stability of target messenger RNA, contributing to cancer pathogenesis. Despite the progress that has been made in discovering the mechanisms of how miRNAs function in tumors, many questions and aspects of miRNA biology and processing still remain to be determined. This Special Issue, titled “MicroRNA in Solid Tumor and Hematological Diseases”, provides a panorama of the existing knowledge gaps and potential uses of microRNAs to predict clinical outcome or response to therapies and provides evidence to explain their role as biomarkers to modulate the biological pathways that are critical for cancer development and progression. It includes eleven peer-reviewed papers that cover the role of microRNAs in different tumor types and their potential applications in diagnosis and clinical approaches. 2022-02-24T10:38:24Z 2022-02-24T10:38:24Z 2022 book ONIX_20220224_9783036530895_139 9783036530895 9783036530888 https://directory.doabooks.org/handle/20.500.12854/78842 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4936 https://mdpi.com/books/pdfview/book/4936 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-3089-5 10.3390/books978-3-0365-3089-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036530895 9783036530888 226 Basel open access |
| spellingShingle | bladder cancer urine miRNA reference miRNA normalizer RT-qPCR miR-139-5p miR-139-3p renal cell carcinoma (RCC) microRNA tumor suppressor paxillin (PXN) acute myeloblastic leukemia acute lymphoblastic leukemia colorectal cancer amino acid transporters LAT1 ASCT2 miRNAs microRNAs GI cancers targeted therapy drug resistance miR-7 gene expression cancer cell prognosis follicular lymphoma marginal zone lymphoma Waldenström’s macroglobulinemia hairy cell leukemia primary cutaneous follicle center lymphoma normal B-cell development therapeutic target diagnosis solid cancer post-transcriptional regulation hepatocellular carcinoma Hippo kinase Yes-associated protein liver disease cancer therapy PDAC survival expression profiling ovarian cancer epithelial ovarian cancer liquid biopsy circulating miRNAs drug response personalized medicine chemotherapy n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general MicroRNA in Solid Tumor and Hematological Diseases |
| title | MicroRNA in Solid Tumor and Hematological Diseases |
| title_full | MicroRNA in Solid Tumor and Hematological Diseases |
| title_fullStr | MicroRNA in Solid Tumor and Hematological Diseases |
| title_full_unstemmed | MicroRNA in Solid Tumor and Hematological Diseases |
| title_short | MicroRNA in Solid Tumor and Hematological Diseases |
| title_sort | microrna in solid tumor and hematological diseases |
| topic | bladder cancer urine miRNA reference miRNA normalizer RT-qPCR miR-139-5p miR-139-3p renal cell carcinoma (RCC) microRNA tumor suppressor paxillin (PXN) acute myeloblastic leukemia acute lymphoblastic leukemia colorectal cancer amino acid transporters LAT1 ASCT2 miRNAs microRNAs GI cancers targeted therapy drug resistance miR-7 gene expression cancer cell prognosis follicular lymphoma marginal zone lymphoma Waldenström’s macroglobulinemia hairy cell leukemia primary cutaneous follicle center lymphoma normal B-cell development therapeutic target diagnosis solid cancer post-transcriptional regulation hepatocellular carcinoma Hippo kinase Yes-associated protein liver disease cancer therapy PDAC survival expression profiling ovarian cancer epithelial ovarian cancer liquid biopsy circulating miRNAs drug response personalized medicine chemotherapy n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general |
| topic_facet | bladder cancer urine miRNA reference miRNA normalizer RT-qPCR miR-139-5p miR-139-3p renal cell carcinoma (RCC) microRNA tumor suppressor paxillin (PXN) acute myeloblastic leukemia acute lymphoblastic leukemia colorectal cancer amino acid transporters LAT1 ASCT2 miRNAs microRNAs GI cancers targeted therapy drug resistance miR-7 gene expression cancer cell prognosis follicular lymphoma marginal zone lymphoma Waldenström’s macroglobulinemia hairy cell leukemia primary cutaneous follicle center lymphoma normal B-cell development therapeutic target diagnosis solid cancer post-transcriptional regulation hepatocellular carcinoma Hippo kinase Yes-associated protein liver disease cancer therapy PDAC survival expression profiling ovarian cancer epithelial ovarian cancer liquid biopsy circulating miRNAs drug response personalized medicine chemotherapy n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general |
| url | ONIX_20220224_9783036530895_139 |