Antisense RNA Design, Delivery, and Analysis

This open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering mo...

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Հրապարակվել է: Springer Nature 2022
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Առցանց հասանելիություն:ONIX_20220314_9781071620106_33
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collection Directory of Open Access Books
description This open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antisense RNA Design, Delivery, and Analysis provides basic knowledge and a large collection of methods to facilitate the work of newcomers to this vibrant and expanding field. This book was conceived thanks to the network DARTER (Delivery of Antisense RNA Therapeutics). DARTER is funded by the EU Cooperation of Science and Technology (COST), which aims to enhance interaction and collaborations between researchers in Europe and other countries.
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spelling doab-20.500.12854ir-793832025-05-09T11:53:42Z Antisense RNA Design, Delivery, and Analysis Arechavala-Gomeza, Virginia Garanto, Alejandro RNA therapeutics Antisense technology Therapeutic design Oligonucleotides Model systems Oligonucleotide-mediated toxicology Open Access This open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antisense RNA Design, Delivery, and Analysis provides basic knowledge and a large collection of methods to facilitate the work of newcomers to this vibrant and expanding field. This book was conceived thanks to the network DARTER (Delivery of Antisense RNA Therapeutics). DARTER is funded by the EU Cooperation of Science and Technology (COST), which aims to enhance interaction and collaborations between researchers in Europe and other countries. 2022-03-16T04:03:54Z 2022-03-16T04:03:54Z 2022-03-15T07:52:49Z 2022 book ONIX_20220314_9781071620106_33 OCN: 1301273481 https://library.oapen.org/handle/20.500.12657/53317 9781071620106 https://directory.doabooks.org/handle/20.500.12854/79383 eng Methods in Molecular Biology open access image/jpeg image/jpeg image/jpeg image/jpeg n/a n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/53317/1/978-1-0716-2010-6.pdf https://library.oapen.org/bitstream/20.500.12657/53317/1/978-1-0716-2010-6.pdf https://library.oapen.org/bitstream/20.500.12657/53317/1/978-1-0716-2010-6.pdf https://library.oapen.org/bitstream/20.500.12657/53317/1/978-1-0716-2010-6.pdf Springer Nature Humana 10.1007/978-1-0716-2010-6 10.1007/978-1-0716-2010-6 9fa3421d-f917-4153-b9ab-fc337c396b5a European Cooperation in Science and Technology f1d9faa0-0bd1-4fe9-9e3a-99696242d3f6 9781071620106 EU collection Humana 422 New York [grantnumber unknown] open access
spellingShingle RNA therapeutics
Antisense technology
Therapeutic design
Oligonucleotides
Model systems
Oligonucleotide-mediated toxicology
Open Access
Antisense RNA Design, Delivery, and Analysis
title Antisense RNA Design, Delivery, and Analysis
title_full Antisense RNA Design, Delivery, and Analysis
title_fullStr Antisense RNA Design, Delivery, and Analysis
title_full_unstemmed Antisense RNA Design, Delivery, and Analysis
title_short Antisense RNA Design, Delivery, and Analysis
title_sort antisense rna design delivery and analysis
topic RNA therapeutics
Antisense technology
Therapeutic design
Oligonucleotides
Model systems
Oligonucleotide-mediated toxicology
Open Access
topic_facet RNA therapeutics
Antisense technology
Therapeutic design
Oligonucleotides
Model systems
Oligonucleotide-mediated toxicology
Open Access
url ONIX_20220314_9781071620106_33