Searching for Order in Body Clocks
Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained...
Tallennettuna:
| Päätekijä: | |
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| Aineistotyyppi: | Online |
| Kieli: | englanti |
| Julkaistu: |
Logos Verlag Berlin
2022
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| Aiheet: | |
| Linkit: | ONIX_20220317_9783832554064_5 |
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| _version_ | 1869522720768655360 |
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| author | del Olmo, Marta |
| author_browse | del Olmo, Marta |
| author_facet | del Olmo, Marta |
| author_sort | del Olmo, Marta |
| collection | Directory of Open Access Books |
| description | Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease. |
| format | Online |
| id | doab-20.500.12854ir-79456 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Logos Verlag Berlin |
| publisherStr | Logos Verlag Berlin |
| record_format | ojs |
| spelling | doab-20.500.12854ir-794562024-04-05T12:33:55Z Searching for Order in Body Clocks del Olmo, Marta Chronobiology Circadian rhythms Redox Metabolism Mathematical modeling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues Physiological rhythms are central to life. Mammalian behavior and metabolism are organized around the day and night by the regulated action of cell-autonomous clocks that exist throughout our bodies. At the core of this molecular clockwork are multiple coupled feedback loops that generate sustained circadian rhythms in gene expression to ultimately orchestrate mammalian physiology. In this work we provide evidence for the role of metabolism in regulating the core clock. We present genes involved in energetic and redox pathways which we identified to be essential for the robustness of cellular timekeepers to temperature fluctuations. We developed the first computational model for circadian redox oscillations that contributes to the understanding of how cellular redox balance might adjust circadian rates in response to perturbations and convey timing information to the core molecular oscillator. Moreover, we show that our mathematical model can be coupled with prior published models of the transcriptional clockwork resulting in 1:1 entrainment. This experimental-theoretical approach exemplifies the need of a dynamic analysis at the system level to understand complex biological processes and provides insights into how basic timekeeping mechanisms are integrated into cellular physiology. Such knowledge might highlight new ways by which functional consequences of circadian timekeeping can be explored in the context of human health and disease. 2022-03-17T15:24:43Z 2022-03-17T15:24:43Z 2021 book ONIX_20220317_9783832554064_5 9783832554064 https://directory.doabooks.org/handle/20.500.12854/79456 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://www.logos-verlag.de/cgi-bin/engbuchmid?isbn=5406&lng=eng&id= https://www.logos-verlag.de/ebooks/OA/978-3-8325-5406-4.pdf Logos Verlag Berlin Logos Verlag Berlin 10.30819/5406 10.30819/5406 04b263a1-7fba-4491-9eae-1c394ac42fc3 9783832554064 Logos Verlag Berlin 234 Berlin open access |
| spellingShingle | Chronobiology Circadian rhythms Redox Metabolism Mathematical modeling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues del Olmo, Marta Searching for Order in Body Clocks |
| title | Searching for Order in Body Clocks |
| title_full | Searching for Order in Body Clocks |
| title_fullStr | Searching for Order in Body Clocks |
| title_full_unstemmed | Searching for Order in Body Clocks |
| title_short | Searching for Order in Body Clocks |
| title_sort | searching for order in body clocks |
| topic | Chronobiology Circadian rhythms Redox Metabolism Mathematical modeling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues |
| topic_facet | Chronobiology Circadian rhythms Redox Metabolism Mathematical modeling thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues |
| url | ONIX_20220317_9783832554064_5 |
| work_keys_str_mv | AT delolmomarta searchingfororderinbodyclocks |