Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues
The cardiac function relies on an intricate molecular and cellular three-dimensional (3d) architecture of a complex, dense and co-dependent cellular network. Structural alterations of the cardiac structure can affect its essential function and lead to severe dysfunction of the organ. Cardiovascular...
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| Médium: | Online |
| Jazyk: | angličtina |
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Universitätsverlag Göttingen
2022
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| Témata: | |
| On-line přístup: | OCN: 1313543805 |
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Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
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| _version_ | 1869520014402387968 |
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| author | Reichardt, Marius |
| author_browse | Reichardt, Marius |
| author_facet | Reichardt, Marius |
| author_sort | Reichardt, Marius |
| collection | Directory of Open Access Books |
| description | The cardiac function relies on an intricate molecular and cellular three-dimensional (3d) architecture of a complex, dense and co-dependent cellular network. Structural alterations of the cardiac structure can affect its essential function and lead to severe dysfunction of the organ. Cardiovascular diseases are the main cause of death worldwide with a rising incidence.
However, it is not possible to give a generalized answer how the heart is formed. Up to now, cardiac structure as well as physiologic and disease-related tissue alterations of the tissue are mainly investigated by established 2d imaging methods such as optical microscopy or electron microscopy.
This work presents a multiscale and multimodal X-ray imaging approach, which allows to probe the heart structure from the scale of entire intact murine hearts to the molecular organisation of the sarcomer structure.
While the molecular structure of the actomyosin complex is probed by scanning X-ray diffraction,
the 3d arrangement of the cellular network is investigated by propagation-based X-ray phase-contrast tomography. In this context, the concept of 3d virtual histology of cardiac tissue by X-ray phase-contrast tomography using laboratory sources as well as highly coherent synchrotron radiation is being further developed. |
| format | Online |
| id | doab-20.500.12854ir-79565 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Universitätsverlag Göttingen |
| publisherStr | Universitätsverlag Göttingen |
| record_format | ojs |
| spelling | doab-20.500.12854ir-795652025-07-30T11:55:13Z Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues Reichardt, Marius X-ray cardiac cells cardiac tissues thema EDItEUR::P Mathematics and Science::PH Physics thema EDItEUR::P Mathematics and Science::PH Physics The cardiac function relies on an intricate molecular and cellular three-dimensional (3d) architecture of a complex, dense and co-dependent cellular network. Structural alterations of the cardiac structure can affect its essential function and lead to severe dysfunction of the organ. Cardiovascular diseases are the main cause of death worldwide with a rising incidence. However, it is not possible to give a generalized answer how the heart is formed. Up to now, cardiac structure as well as physiologic and disease-related tissue alterations of the tissue are mainly investigated by established 2d imaging methods such as optical microscopy or electron microscopy. This work presents a multiscale and multimodal X-ray imaging approach, which allows to probe the heart structure from the scale of entire intact murine hearts to the molecular organisation of the sarcomer structure. While the molecular structure of the actomyosin complex is probed by scanning X-ray diffraction, the 3d arrangement of the cellular network is investigated by propagation-based X-ray phase-contrast tomography. In this context, the concept of 3d virtual histology of cardiac tissue by X-ray phase-contrast tomography using laboratory sources as well as highly coherent synchrotron radiation is being further developed. 2022-03-21T04:01:48Z 2022-03-21T04:01:48Z 2022-03-20T04:30:46Z 2022 book book OCN: 1313543805 https://library.oapen.org/handle/20.500.12657/53509 978-3-86395-536-6 https://directory.doabooks.org/handle/20.500.12854/79565 eng open access image/jpeg image/jpeg image/jpeg image/jpeg n/a n/a n/a n/a https://library.oapen.org/bitstream/20.500.12657/53509/1/GSXP28_reichardt.pdf https://library.oapen.org/bitstream/20.500.12657/53509/1/GSXP28_reichardt.pdf https://library.oapen.org/bitstream/20.500.12657/53509/1/GSXP28_reichardt.pdf https://library.oapen.org/bitstream/20.500.12657/53509/1/GSXP28_reichardt.pdf Universitätsverlag Göttingen af9011e0-03b9-4a5c-9ae6-b9da4898d1b2 978-3-86395-536-6 AG Universitätsverlage open access |
| spellingShingle | X-ray cardiac cells cardiac tissues thema EDItEUR::P Mathematics and Science::PH Physics thema EDItEUR::P Mathematics and Science::PH Physics Reichardt, Marius Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues |
| title | Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues |
| title_full | Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues |
| title_fullStr | Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues |
| title_full_unstemmed | Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues |
| title_short | Multiscale X-ray Structural Analysis of Cardiac Cells and Tissues |
| title_sort | multiscale x ray structural analysis of cardiac cells and tissues |
| topic | X-ray cardiac cells cardiac tissues thema EDItEUR::P Mathematics and Science::PH Physics thema EDItEUR::P Mathematics and Science::PH Physics |
| topic_facet | X-ray cardiac cells cardiac tissues thema EDItEUR::P Mathematics and Science::PH Physics thema EDItEUR::P Mathematics and Science::PH Physics |
| url | OCN: 1313543805 |
| work_keys_str_mv | AT reichardtmarius multiscalexraystructuralanalysisofcardiaccellsandtissues |