Oligonucleotide, Therapy, and Applications
Oligonucleotides (ON) constitute a new group of molecular agents, the object of significant interest due to their potential value as drugs for diagnostic and therapeutic applications. Their special interest derives from the intrinsic characteristics of ONs: a) ONs are informative agents, a property...
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| Materiálatiipa: | Online |
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| Giella: | eaŋgalasgiella |
| Almmustuhtton: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Fáttát: | |
| Liŋkkat: | ONIX_20220321_9783036530574_7 |
| Fáddágilkorat: |
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| _version_ | 1869517049900826624 |
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| collection | Directory of Open Access Books |
| description | Oligonucleotides (ON) constitute a new group of molecular agents, the object of significant interest due to their potential value as drugs for diagnostic and therapeutic applications. Their special interest derives from the intrinsic characteristics of ONs: a) ONs are informative agents, a property that derives from the order in which the nucleotides of each particular ON are arranged; b) ONs can act as ligands (ASO, TFO, aptamers, G-quadruplex, etc.) of complementary nucleic acid sequences (DNA or RNA) due to their high capacity to hybridize (by means of Watson and Crick or Hoogsteen links) with other nucleotide sequences, resulting in specific gene modulatory effects. However, nonspecific sequences may also be of interest, as is the case with repetitive nucleotide sequences (CpG) with adjuvant effects of vaccines; c) ONs can also rapidly evolve to achieve specific advantages of utility (targeting, stability, efficacy, toxicity, etc.) or high-sensitivity diagnostic technology (markers, analyzes, biosensors, FISH, microarrays, etc.), by chemical modification of nucleotides in any of their atoms. These properties show that ONs are first-order molecules due to their potential usefulness in practice.In this collection of research articles and review papers, we aim to highlight their therapeutic, but also diagnostic and technological utility as drugs. |
| format | Online |
| id | doab-20.500.12854ir-79571 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-795712024-03-30T23:22:01Z Oligonucleotide, Therapy, and Applications Aliño, Salvador Sendra, Luis quantum dots (QDs) DNAzyme ROS Amplex Red light-induced activity DNA methylation histone code microRNA nanoparticles noncoding RNA pulmonary arterial hypertension aptamer aptasensor influenza SERS virus detection α-synuclein antisense oligonucleotide dopamine neurotransmission double mutant A30P*A53T* motor deficits Parkinson’s disease transgenic mouse model G-quadruplexes covalent dimer construct anti-proliferative activity primary cell culture of human glioma antisensense oligonucleotide Foxp3 regulatory T cells vaccine immunogenicity Sporothrix schenckii Marfan syndrome fibrillin-1 antisense oligonucleotides exon skipping splice-switching thema EDItEUR::M Medicine and Nursing Oligonucleotides (ON) constitute a new group of molecular agents, the object of significant interest due to their potential value as drugs for diagnostic and therapeutic applications. Their special interest derives from the intrinsic characteristics of ONs: a) ONs are informative agents, a property that derives from the order in which the nucleotides of each particular ON are arranged; b) ONs can act as ligands (ASO, TFO, aptamers, G-quadruplex, etc.) of complementary nucleic acid sequences (DNA or RNA) due to their high capacity to hybridize (by means of Watson and Crick or Hoogsteen links) with other nucleotide sequences, resulting in specific gene modulatory effects. However, nonspecific sequences may also be of interest, as is the case with repetitive nucleotide sequences (CpG) with adjuvant effects of vaccines; c) ONs can also rapidly evolve to achieve specific advantages of utility (targeting, stability, efficacy, toxicity, etc.) or high-sensitivity diagnostic technology (markers, analyzes, biosensors, FISH, microarrays, etc.), by chemical modification of nucleotides in any of their atoms. These properties show that ONs are first-order molecules due to their potential usefulness in practice.In this collection of research articles and review papers, we aim to highlight their therapeutic, but also diagnostic and technological utility as drugs. 2022-03-21T16:26:36Z 2022-03-21T16:26:36Z 2022 book ONIX_20220321_9783036530574_7 9783036530574 9783036530567 https://directory.doabooks.org/handle/20.500.12854/79571 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/4951 https://mdpi.com/books/pdfview/book/4951 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-3056-7 10.3390/books978-3-0365-3056-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036530574 9783036530567 123 Basel open access |
| spellingShingle | quantum dots (QDs) DNAzyme ROS Amplex Red light-induced activity DNA methylation histone code microRNA nanoparticles noncoding RNA pulmonary arterial hypertension aptamer aptasensor influenza SERS virus detection α-synuclein antisense oligonucleotide dopamine neurotransmission double mutant A30P*A53T* motor deficits Parkinson’s disease transgenic mouse model G-quadruplexes covalent dimer construct anti-proliferative activity primary cell culture of human glioma antisensense oligonucleotide Foxp3 regulatory T cells vaccine immunogenicity Sporothrix schenckii Marfan syndrome fibrillin-1 antisense oligonucleotides exon skipping splice-switching thema EDItEUR::M Medicine and Nursing Oligonucleotide, Therapy, and Applications |
| title | Oligonucleotide, Therapy, and Applications |
| title_full | Oligonucleotide, Therapy, and Applications |
| title_fullStr | Oligonucleotide, Therapy, and Applications |
| title_full_unstemmed | Oligonucleotide, Therapy, and Applications |
| title_short | Oligonucleotide, Therapy, and Applications |
| title_sort | oligonucleotide therapy and applications |
| topic | quantum dots (QDs) DNAzyme ROS Amplex Red light-induced activity DNA methylation histone code microRNA nanoparticles noncoding RNA pulmonary arterial hypertension aptamer aptasensor influenza SERS virus detection α-synuclein antisense oligonucleotide dopamine neurotransmission double mutant A30P*A53T* motor deficits Parkinson’s disease transgenic mouse model G-quadruplexes covalent dimer construct anti-proliferative activity primary cell culture of human glioma antisensense oligonucleotide Foxp3 regulatory T cells vaccine immunogenicity Sporothrix schenckii Marfan syndrome fibrillin-1 antisense oligonucleotides exon skipping splice-switching thema EDItEUR::M Medicine and Nursing |
| topic_facet | quantum dots (QDs) DNAzyme ROS Amplex Red light-induced activity DNA methylation histone code microRNA nanoparticles noncoding RNA pulmonary arterial hypertension aptamer aptasensor influenza SERS virus detection α-synuclein antisense oligonucleotide dopamine neurotransmission double mutant A30P*A53T* motor deficits Parkinson’s disease transgenic mouse model G-quadruplexes covalent dimer construct anti-proliferative activity primary cell culture of human glioma antisensense oligonucleotide Foxp3 regulatory T cells vaccine immunogenicity Sporothrix schenckii Marfan syndrome fibrillin-1 antisense oligonucleotides exon skipping splice-switching thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20220321_9783036530574_7 |